- Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors
-
Park J, Yoo HM, Sul HJ, Shin S, Lee SW, Kim JG
- KMID: 2471923
- J Gastric Cancer.
- 2020 Mar;20(1):29-40.
- doi: 10.5230/jgc.2020.20.e2
PURPOSE: Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors.... -
- CITED
-
- Close
- SHARE
-
- Close
- Phase II Study of Dovitinib in Patients with Castration-Resistant Prostate Cancer (KCSG-GU11-05)
-
Choi YJ, Kim HS, Park SH, Kim BS, Kim KH, Lee HJ, Song HS, Shin DY, Lee HY, Kim HG, Lee KH, Lee JL, Park KH
- KMID: 2424797
- Cancer Res Treat.
- 2018 Oct;50(4):1252-1259.
- doi: 10.4143/crt.2017.438
PURPOSE: Fibroblast growth factor (FGF) signals are important in carcinogenesis and progression of prostate cancer. Dovitinib is an oral, pan-class inhibitor of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth... -
- CITED
-
- Close
- SHARE
-
- Close
- Platelet-Derived Growth Factor Receptor-Positive Pericytic Cells of White Adipose Tissue from Critical Limb Ischemia Patients Display Mesenchymal Stem Cell-Like Properties
-
Kim EJ, Seo SG, Shin HS, Lee DJ, Kim JH, Lee DY
- KMID: 2412295
- Clin Orthop Surg.
- 2017 Jun;9(2):239-248.
- doi: 10.4055/cios.2017.9.2.239
BACKGROUND: The pericytes in the blood vessel wall have recently been identified to be important in regulating vascular formation, stabilization, remodeling, and function. We isolated and identified pericyte-like platelet-derived growth... -
- CITED
-
- Close
- SHARE
-
- Close
- A Case of Myeloid Neoplasm with a PDGFRB Rearrangement and Eosinophilia
-
Cho NG, Kim D, Shim M, Chong SY
- KMID: 2376949
- Korean J Med.
- 2017 Feb;92(1):79-83.
- doi: 10.3904/kjm.2017.92.1.79
Myeloid neoplasia with eosinophilia and platelet-derived growth factor receptor beta (PDGFRB) rearrangements is an uncommon Philadelphia-negative myeloproliferative neoplasm. Their most common morphological diagnosis is chronic myelomonocytic leukemia with eosinophilia, which... -
- CITED
-
- Close
- SHARE
-
- Close
- Different anti-remodeling effect of nilotinib and fluticasone in a chronic asthma model
-
Kang HS, Rhee CK, Lee HY, Yoon HK, Kwon SS, Lee SY
- KMID: 2382865
- Korean J Intern Med.
- 2016 Nov;31(6):1150-1158.
- doi: 10.3904/kjim.2015.002
BACKGROUND/AIMS: Inhaled corticosteroids are the most effective treatment currently available for asthma, but their beneficial effect against airway remodeling is limited. The tyrosine kinase inhibitor nilotinib has inhibitory activity against... -
- CITED
-
- Close
- SHARE
-
- Close
- Efficacy of Imatinib in Patients with Platelet-Derived Growth Factor Receptor Alpha-Mutated Gastrointestinal Stromal Tumors
-
Yoo C, Ryu MH, Jo J, Park I, Ryoo BY, Kang YK
- KMID: 2454331
- Cancer Res Treat.
- 2016 Apr;48(2):546-552.
- doi: 10.4143/crt.2015.015
PURPOSE: The incidence of gastrointestinal stromal tumors (GISTs) harboring platelet-derived growth factor receptor alpha (PDGFRA) mutations is low, therefore further investigation of the efficacy of imatinib in this subgroup was... -
- CITED
-
- Close
- SHARE
-
- Close
- VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma
-
Park S, Nam SJ, Keam B, Kim TM, Jeon YK, Lee SH, Hah JH, Kwon TK, Kim DW, Sung MW, Heo DS, Bang YJ
- KMID: 2454328
- Cancer Res Treat.
- 2016 Apr;48(2):518-526.
- doi: 10.4143/crt.2015.093
PURPOSE: The purpose of this study was to evaluate potential prognostic factors in patients with adenoid cystic carcinoma (ACC). MATERIALS AND METHODS: A total of 68 patients who underwent curative surgery... -
- CITED
-
- Close
- SHARE
-
- Close
- Serum Response Factor Is Essential for Prenatal Gastrointestinal Smooth Muscle Development and Maintenance of Differentiated Phenotype
-
Park C, Lee MY, Park PJ, Ha SE, Berent RM, Fuchs R, Miano JM, Becker LS, Sanders KM, Ro S
- KMID: 2381308
- J Neurogastroenterol Motil.
- 2015 Oct;21(4):589-602.
- doi: 10.5056/jnm15063
BACKGROUND/AIMS: Smooth muscle cells (SMCs) characteristically express serum response factor (SRF), which regulates their development. The role of SRF in SMC plasticity in the pathophysiological conditions of gastrointestinal (GI) tract... -
- CITED
-
- Close
- SHARE
-
- Close
- The Significance of Interstitial Cells in Neurogastroenterology
-
Blair PJ, Rhee PL, Sanders KM, Ward SM
- KMID: 2381189
- J Neurogastroenterol Motil.
- 2014 Jul;20(3):294-317.
Smooth muscle layers of the gastrointestinal tract consist of a heterogeneous population of cells that include enteric neurons, several classes of interstitial cells of mesenchymal origin, a variety of immune... -
- CITED
-
- Close
- SHARE
-
- Close
- The Physiologic Roles of the Subepithelial Platelet-derived Growth Factor Receptor alpha-positive Cells in the Colon (Am J Physiol Gastrointest Liver Physiol 2013;304:G823-G834)
-
Kim HJ
- KMID: 2381159
- J Neurogastroenterol Motil.
- 2014 Jan;20(1):127-128.
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Ionic Conductance(s) in Response to Post-junctional Potentials
-
Koh SD, Rhee PL
- KMID: 2325763
- J Neurogastroenterol Motil.
- 2013 Oct;19(4):426-432.
The gastrointestinal motility is regulated by extrinsic and intrinsic neural regulation. Intrinsic neural pathways are controlled by sensory input, inter-neuronal relay and motor output. Enteric motor neurons release many transmitters... -
- CITED
-
- Close
- SHARE
-
- Close
- The KIT Exon 11 Stop Codon Mutation in Gastrointestinal Stromal Tumors: What Is the Clinical Meaning?
-
Michelucci A, Chiappetta C, Cacciotti , Veccia N, Astri E, Leopizzi M, Prosperi Porta R, Petrozza V, Della Rocca C, Bevilacqua G, Cavazzana , Di Cristofano C
- KMID: 2053513
- Gut Liver.
- 2013 Jan;7(1):35-40.
BACKGROUND/AIMS: Gastrointestinal stromal tumors (GISTs) strongly express a receptor tyrosine kinase (RTK, c-KIT-CD117) harboring a KIT mutation that causes constitutive receptor activation leading to the development and growth of tumors;... -
- CITED
-
- Close
- SHARE
-
- Close
- Target Therapy for Hepatocellular Carcinoma
-
Yoon SK
- KMID: 2168205
- Hanyang Med Rev.
- 2012 May;32(2):118-125.
- doi: 10.7599/hmr.2012.32.2.118
Hepatocellular carcinoma (HCC) is a highly malignant tumor that has limited treatment options in its advanced state. The efficacy of current anti-cancer chemotherapy in advanced HCC has not been satisfactory,... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of Angiogenic Factors in Airway Remodeling in an Allergic Rhinitis Murine Model
-
Moon IJ, Kim DY, Rhee CS, Lee CH, Min YG
- KMID: 2130377
- Allergy Asthma Immunol Res.
- 2012 Jan;4(1):37-45.
- doi: 10.4168/aair.2012.4.1.37
PURPOSE: There is growing evidence that nasal airway remodeling occurs in allergic rhinitis (AR). Although angiogenesis is an important component of airway remodeling in asthma, its involvement in AR has... -
- CITED
-
- Close
- SHARE
-
- Close
- Smooth Muscles Contraction in Gastrointestinal Tract and New Concept of Enteric Neurotransmission: Fibroblast-like Cells
-
Kim HJ
- KMID: 2264025
- Korean J Med.
- 2011 Sep;81(3):315-321.
This review provides information regarding an enteric neurotransmission from enteric nerve terminals to smooth muscles. In the gastrointestinal tract, phasic contractions are caused by electrical activity termed slow waves. Slow... -
- CITED
-
- Close
- SHARE
-
- Close
- Combined Treatment with Anticancer Vaccine Using Genetically Modified Endothelial Cells and Imatinib in Bladder Cancer
-
Ha SB, Park YH, Lee E, Ku JH, Kim HH, Kwak C
- KMID: 2315520
- Korean J Urol.
- 2011 May;52(5):327-334.
PURPOSE: We sought to maximize the antitumor effect of an anticancer vaccine based on genetically modified endothelial cells by combining it with the platelet-derived growth factor receptor inhibitor imatinib. MATERIALS AND... -
- CITED
-
- Close
- SHARE
-
- Close
- Imatinib Mesylate (Gleevec(TM))-induced Lichenoid Drug Eruption Improved by Tentative Dose-reduction and Topical Steroid
-
Yang JH, Shin JW, Kim HD, Park YL, Lee SY, Whang KU
- KMID: 2303581
- Korean J Dermatol.
- 2011 Feb;49(2):155-158.
Imatinib mesylate (Gleevec(TM)) is an oral anticancer drug. It works as a selective and competitive inhibitor of tyrosine kinases such as bcr-abl protein, c-kit, and platelet-derived growth factor receptors (PDGFR).... -
- CITED
-
- Close
- SHARE
-
- Close
- Mutation-Free Expression of c-Kit and PDGFRA in Phyllodes Tumors of the Breast
-
Jung CW, Suh KS, Lee JS, Kim JR, Chang ES, Sul HJ, Park MJ
- KMID: 2425144
- J Breast Cancer.
- 2010 Sep;13(3):257-266.
PURPOSE: Phyllodes tumors (PTs) of the breast have been classified as benign, borderline, or malignant based on their histopathologic features. However, predicting clinical behavior based on these features has proven... -
- CITED
-
- Close
- SHARE
-
- Close
- Clinicopathological and Immunohistochemical Features of Gastointestinal Stromal Tumors
-
Kang YN, Jung HR, Hwang I
- KMID: 2270802
- Cancer Res Treat.
- 2010 Sep;42(3):135-143.
PURPOSE: The purpose of this study was to evaluate the clinicopathological features and immunohistochemical features of gastrointestinal stromal tumor (GIST), and specifically the expressions of platelet derived growth factor receptor... -
- CITED
-
- Close
- SHARE
-
- Close
- An Approach to Diagnosing Gastrointestinal Stromal Tumors Using Immunohistochemistry of c-kit and PDGFRA with Molecular Analysis
-
Kim JS, Kim JH, Oh HJ, Suh IS, Kim JG, Kang BW, Yu WS, Chung HY, Bae HI
- KMID: 2277606
- Korean J Pathol.
- 2010 Apr;44(2):173-178.
BACKGROUND: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors in the gastrointestinal tract. Recently, many methods for the diagnosis of GIST have been developed including molecular diagnosis. METHODS: We... -
- CITED
-
- Close
- SHARE
-
- Close
