Korean J Med.  2017 Feb;92(1):79-83. 10.3904/kjm.2017.92.1.79.

A Case of Myeloid Neoplasm with a PDGFRB Rearrangement and Eosinophilia

• Cho NG
• Kim D
• Shim M
• Chong SY

• KMID: 2376949
• DOI: http://doi.org/10.3904/kjm.2017.92.1.79

Abstract

Myeloid neoplasia with eosinophilia and platelet-derived growth factor receptor beta (PDGFRB) rearrangements is an uncommon Philadelphia-negative myeloproliferative neoplasm. Their most common morphological diagnosis is chronic myelomonocytic leukemia with eosinophilia, which is associated with t(5;12)(q33;p13) and results in the formation of the ETV6-PDGFRB fusion gene. Here, we report a 49-year-old man with a myeloid neoplasm with a PDGFRB rearrangement, who was incidentally diagnosed with hyperleukocytosis and eosinophilia during a health screening. A chromosome analysis of a bone marrow sample revealed 46, XY, t(5;12)(q33;p13), and fluorescence in situ hybridization analysis revealed the PDGFRB gene rearrangement. The patient was treated with imatinib and subsequently achieved complete hematological and molecular remission.

Keyword

Myeloproliferative disorder; PDGFRB; Eosinophilia; Imatinib mesylate

MeSH Terms

Bone Marrow
Diagnosis
Eosinophilia*
Fluorescence
Gene Rearrangement
Humans
Imatinib Mesylate
In Situ Hybridization
Leukemia, Myelomonocytic, Chronic
Mass Screening
Middle Aged
Myeloproliferative Disorders
Receptor, Platelet-Derived Growth Factor beta*
Receptors, Platelet-Derived Growth Factor
Imatinib Mesylate
Receptor, Platelet-Derived Growth Factor beta
Receptors, Platelet-Derived Growth Factor