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Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity

Febres-Aldana CA, Mejia-Mejia O, Krishnamurthy K, Mesko T, Poppiti R

Breast adenomyoepitheliomas are composed of a biphasic proliferation of myoepithelial cells around small epithelial-lined spaces. Due to the rarity of adenomyoepitheliomas, the molecular data describing them are limited. Adenomyoepitheliomas are...
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Association between Dry Eye Questionnaires and Dry Eye Sign in Meibomian Gland Dysfunction

Kim JA, Lee SH

PURPOSE: The Ocular Surface Disease Index (OSDI) and the Standardized Patient Evaluation of Eye Dryness (SPEED) which are standard questionnaires of dry eye syndrome were used to determine the associations...
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Suspension culture of Vero cells for the production of adenovirus type 5

Lee DK, Park J, Seo DW

PURPOSE: Most cell culture processes for viral vaccine production are mainly based on adherent cell culture systems using serum, which are associated with expensive and labor-intensive processes to produce large...
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Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells

Hwang S, Kim JK

We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours...
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A Case of Donor Cell Leukemia after Allogenic Peripheral Blood Stem Cell Transplantation for Acute Promyelocytic Leukemia with PML-RARA

Shin WY, Bang HI, Kim J, Kim KH, Won JH, Park R

Donor cell leukemia (DCL), a rare but fatal complication arising from allogenic stem cell transplantation, is a complex disease associated with multiple pathophysiological processes. Specific diagnosis of DCL distinct from...
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Detection of Anti-Extractable Nuclear Antigens in Patients with Systemic Rheumatic Disease via Fluorescence Enzyme Immunoassay and Its Clinical Utility

Oh J, Park Y, Lee KA, Kim HS

PURPOSE: Testing for autoantibodies to extractable nuclear antigens (ENAs) plays an important role in the diagnosis and management of systemic rheumatic disease. Currently, no gold standard tests are available for...
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Electroretinography Changes in Feline Model of Iodoacetic Acid-induced Retinal Degeneration

Kim C, Lee M, Lee SU, Lee SJ

PURPOSE: We explored changes in photoreceptor function and histology in an iodoacetic acid (IAA)-induced model of feline retinal degeneration. METHODS: From January to October 2014, we studied 11 adult felines (22...
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Bioactive characteristics of an implant surface coated with a pH buffering agent: an in vitro study

Pae HC, Kim SK, Park JY, Song YW, Cha JK, Paik JW, Choi SH

PURPOSE: The purpose of this study was to evaluate the effectiveness of conventional sandblasted, large-grit, acid-etched (SLA) surface coated with a pH buffering solution based on surface wettability, blood protein...
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Pure 3D laparoscopy versus open right hemihepatectomy in a donor with type II and III portal vein variations

Park K, Shehta A, Lee JM, Hong SK, Yoon KC, Cho JH, Yi NJ, Lee KW, Suh KS

BACKGROUNDS/AIMS: Pure laparoscopic living donor right hemihepatectomy (PLDRH) has been performed in many experienced centers. However, portal vein variations still remain challenging thus disturbing the widespread of PLDRH in many...
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EDTA Treatment for Overcoming the Prozone Effect and for Predicting C1q Binding in HLA Antibody Testing

Kim HS, Choi AR, Yang M, Oh EJ

The Luminex-based single antigen bead (SAB) assay is widely used to detect HLA antibody in transplant recipients. However, one limitation of the SAB assay is the prozone effect, which occurs...
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Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus

Lee TK, Park YE, Park CW, Kim B, Lee JC, Park JH, Lee HA, Won MH, Ahn JH

P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult...
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Pathology of C3 Glomerulopathy

Shin SJ, Seong Y, Lim BJ

C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed...
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Near-Infrared Contrast Agents for Bone-Targeted Imaging

Jung JS, Jo D, Jo G, Hyun H

BACKGROUND: For the bone-specific imaging, a structure-inherent targeting of bone tissue recently has been reported a new strategy based on incorporation of targeting moieties into the chemical structure of near-infrared...
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Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine

Yang C, Park GK, McDonald E, Choi HS

BACKGROUND: Advances in tissue engineering and regenerative medicine over the last three decades have made great progress in the development of diagnostic and therapeutic methodologies for damaged tissues. However, regenerative...
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Experience Profiling of Fluorescence-Guided Surgery II: Non-Glioma Pathologies

Ji SY, Kim JW, Park CK

BACKGROUND: Only sporadic reports of fluorescence-guided surgery (FGS) have been published for non-glioma conditions. In this study, we focus on epidemiological data of fluorescence patterns and report the diverse experiences...
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Experience Profiling of Fluorescence-Guided Surgery I: Gliomas

Ji SY, Kim JW, Park CK

BACKGROUND: Numerous studies reported a usefulness of 5-aminolevulinic acid (5-ALA) fluorescence-guided surgery (FGS) in high grade gliomas. However, fluorescence patterns and intensities are variable among gliomas. In this study, we...
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Antifungal Activities of Streptomyces blastmyceticus Strain 12-6 Against Plant Pathogenic Fungi

Kim YJ, Kim JH, Rho JY

Streptomyces blastmyceticus strain 12-6 was isolated from a forest soil sample of Cheonan area on the basis of strong antifungal activities against plant pathogenic fungi. Butanol extracts of the cultural...
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Recharacterization of the Canine Adenovirus Type 1 Vaccine Strain based on the Biological and Molecular Properties

Yang DK, Kim HH, Lee EJ, Yoo JY, Yoon SS, Park J, Kim CH, Kim HR

Canine adenovirus type 1 (CAV-1) infection results in hepatitis in dogs. In this study, we investigated the biologic and genetic characteristics of the CAV-1 vaccine strain (CAV1V) to improve quality...
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Radially patterned polycaprolactone nanofibers as an active wound dressing agent

Shin D, Kim MS, Yang CE, Lee WJ, Roh TS, Baek W

BACKGROUND: The objectives of this study were to design polycaprolactone nanofibers with a radial pattern using a modified electrospinning method and to evaluate the effect of radial nanofiber deposition on...
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Induction of cell deathin early developmental phase of zebrafish treated with diethylnitrosamine

Kang JS

The purpose of this study was to investigate diethylnitrosamine (DEN)-induced liver damage in zebrafish. Zebrafish larvae were divided into five groups after seventy-two hours fertilization: group 1 (G1) as control,...
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