- Lovastatin derivative dehydrolovastatin ameliorates ulcerative colitis in mice by suppressing NF-κB and inflammatory cytokine expression
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Zhang X, Deng QH, Deng JH, Wang SJ, Chen Q
- KMID: 2471035
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):137-147.
- doi: 10.4196/kjpp.2020.24.2.137
Ulcerative colitis (UC) is associated with intestinal immune imbalance and inflammatory response. Because dehydrolovastatin (DLVT), a derivative of lovastatin, has been recently shown to inhibit inflammation and relieve immune arthritis... -
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- Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
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Kim MJ, Kim NY, Jung YA, Lee S, Jung GS, Kim JG, Lee IK, Lee S, Choi YK, Park KG
- KMID: 2470966
- Diabetes Metab J.
- 2020 Feb;44(1):186-192.
- doi: 10.4093/dmj.2018.0271
Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect... -
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- Effect of Sodium Cromoglycate on Acetic Acid-induced Ulcerative Colitis in Mice
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Ghafouri Z, Seyyedian , Nikbakht J, Kouhsari E, Bayat S, Zargar H, Houshmand
- KMID: 2471138
- Korean J Gastroenterol.
- 2020 Jan;75(1):39-45.
- doi: 10.4166/kjg.2020.75.1.39
BACKGROUND/AIMS: Ulcerative colitis (UC) is a type of inflammatory bowel disease that mainly involves the colon. Thus far, glucocorticoids and amino-salicylate have been the main treatment. METHODS: To assess drugs with... -
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- Restoration of the inflammatory gene expression by horse oil in DNCB-treated mice skin
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Lee JC, Park GR, Choi BS, Lee Y, Han CH
- KMID: 2469029
- J Vet Sci.
- 2020 Jan;21(1):e15.
- doi: 10.4142/jvs.2020.21.e15
The present study evaluated the anti-inflammatory effect of horse oil in 2, 4-dinitrochlorobenzene (DNCB)-treated BALB/c mice. After the application of DNCB, the mice showed atopic dermatitis symptoms, including severe erythema,... -
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- High-definition ultrasound characterization of acute cyclophosphamide-induced cystitis in the mouse
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Lee TG, Sanderson , Doyle P, Li D, Wood RW
- KMID: 2466795
- Investig Clin Urol.
- 2020 Jan;61(1):75-80.
- doi: 10.4111/icu.2020.61.1.75
PURPOSE: To examine associations if any between changes in voiding function, hematuria, and bladder ultrasonography metrics in murine cyclophosphamide-induced chemical cystitis. MATERIALS AND METHODS: Cystitis was induced in 6 female mice... -
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- Spatiotemporal expression of RCAN1 and its isoform RCAN1-4 in the mouse hippocampus after pilocarpine-induced status epilepticus
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Cho KO, Jeong KH, Cha JH, Kim SY
- KMID: 2466572
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):81-88.
- doi: 10.4196/kjpp.2020.24.1.81
Regulator of calcineurin 1 (RCAN1) can be induced by an intracellular calcium increase and oxidative stress, which are characteristic features of temporal lobe epilepsy. Thus, we investigated the spatiotemporal expression... -
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- Interaction of genetic background and exercise training intensity on endothelial function in mouse aorta
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Kim SK, Avila JJ, Massett MP
- KMID: 2466570
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):53-68.
- doi: 10.4196/kjpp.2020.24.1.53
The purpose of this study was to characterize the genetic contribution to endothelial adaptation to exercise training. Vasoreactivity was assessed in aortas from four inbred mouse strains (129S1, B6, NON,... -
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- β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice
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Ye JY, Li L, Hao QM, Qin Y, Ma CS
- KMID: 2466568
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):39-46.
- doi: 10.4196/kjpp.2020.24.1.39
Alzheimer's disease (AD) is the most common neurodegenerative disorder causing dementia worldwide, and is mainly characterized by aggregated β-amyloid (Aβ). Increasing evidence has shown that plant extracts have the potential... -
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- Antibiotics-Induced Dysbiosis of Intestinal Microbiota Aggravates Atopic Dermatitis in Mice by Altered Short-Chain Fatty Acids
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Kim HJ, Lee SH, Hong SJ
- KMID: 2462578
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):137-148.
- doi: 10.4168/aair.2020.12.1.137
PURPOSE: Alterations in the intestinal microbiota in early life affects the development of atopic dermatitis (AD) in humans. This study aimed to further investigate the effects of gut dysbiosis in... -
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- Effects of teriparatide on bone in autochthonous transgenic model mice for diabetes mellitus (Akita mice)
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Ohuchi K, Miyakoshi , Kasukawa Y, Segawa T, Kinoshita , Sato C, Fujii M, Shimada Y
- KMID: 2470596
- Osteoporos Sarcopenia.
- 2019 Dec;5(4):109-115.
- doi: 10.1016/j.afos.2019.11.003
OBJECTIVES: The purpose of this study is to evaluate the effects of teriparatide (TPTD) on bone mineral density (BMD), bone strength, and bone quality in Akita mouse models of diabetes... -
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- GABAergic neuronal development in the embryonic mesencephalon of mice
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- KMID: 2470119
- Korean J Vet Res.
- 2019 Dec;59(4):201-205.
- doi: 10.14405/kjvr.2019.59.4.201
This study presents neurogenesis and neuronal migration patterns of gamma-aminobutyric acid-ergic (GABAergic) neurons during mesencephalic development of mouse. After neurons from embryonic day (E) 10-16 were labelled by a single... -
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- Four amino acids as serum biomarkers for anti-asthma effects in the ovalbumin-induced asthma mouse model treated with extract of Asparagus cochinchinensis
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Choi JY, Kim SH, Kim JE, Park JW, Kang MJ, Choi HJ, Bae SJ, Lee JH, Jung YS, Hwang DY
- KMID: 2470022
- Lab Anim Res.
- 2019 Dec;35(4):238-247.
- doi: 10.1186/s42826-019-0033-x
The butanol extract of Asparagus cochinchinensis roots fermented with Weissella cibaria (BAW) effectively prevents inflammation and remodeling of airway in the ovalbumin (OVA)-induced asthma model. To characterize biomarkers that can... -
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- Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to induce sleep
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Kim GH, Yi SS
- KMID: 2470021
- Lab Anim Res.
- 2019 Dec;35(4):230-237.
- doi: 10.1186/s42826-019-0034-9
Although the number of prescriptions and dependence on sleeping pills are increasing, the associations with unexpected abnormal behaviors and metabolic diseases caused by the overuse of sleeping pills are not... -
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- TarGo: network based target gene selection system for human disease related mouse models
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Hyung D, Mallon AM, Kyung DS, Cho SY, Seong JK
- KMID: 2470013
- Lab Anim Res.
- 2019 Dec;35(4):165-171.
- doi: 10.1186/s42826-019-0023-z
Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with detectable phenotypes are... -
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- Effects of dynamic oxygen concentrations on the development of mouse pre- and peri-implantation embryos using a double-channel gas supply incubator system
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Lee SC, Seo HC, Lee J, Jun JH, Choi KW
- KMID: 2469595
- Clin Exp Reprod Med.
- 2019 Dec;46(4):189-196.
- doi: 10.5653/cerm.2019.00514
OBJECTIVE: We aimed to evaluate the effects of different oxygen conditions (20% [high Oâ‚‚], 5% [low Oâ‚‚] and 5% decreased to 2% [dynamic Oâ‚‚]) on mouse pre- and peri-implantation development... -
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- Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia
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Jeon GW, Sheldon RA, Ferriero D
- KMID: 2469014
- Korean J Pediatr.
- 2019 Dec;62(12):444-449.
- doi: 10.3345/kjp.2019.00850
BACKGROUND: Sixty percent of infants with severe neonatal hypoxic-ischemic encephalopathy die, while most survivors have permanent disabilities. Treatment for neonatal hypoxic-ischemic encephalopathy is limited to therapeutic hypothermia, but it does... -
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- Three-Dimensional Analysis of Mouse Habenula Subnuclei Reveals Reduced Volume and Gene Expression in the Lipopolysaccharide-mediated Depression Model
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Yang E, Kim JY, Yang SH, Lee E, Sun W, Lee HW, Kim H
- KMID: 2468887
- Exp Neurobiol.
- 2019 Dec;28(6):709-719.
- doi: 10.5607/en.2019.28.6.709
The habenula (Hb) is small but important brain structure, anatomically and functionally links the forebrain with the midbrain to modulate various neuropsychiatric functions associated with drug addiction and emotion-associated dysfunctions.... -
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- Recapitulation of Neuropsychiatric Behavioral Features in Mice Using Acute Low-dose MK-801 Administration
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Mabunga DF, Park D, Ryu O, Valencia S, Adil KJ, Kim S, Kwon KJ, Shin CY, Jeon SJ
- KMID: 2468886
- Exp Neurobiol.
- 2019 Dec;28(6):697-708.
- doi: 10.5607/en.2019.28.6.697
Despite some innate limitations, animal models are a potent investigative tool when used to model specific symptoms of a disorder. For example, MK-801, an N-methyl-D-aspartate receptor antagonist, is used as... -
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- Docosahexaenoic Acid Inhibits Expression of Fibrotic Mediators in Mice With Chronic Pancreatitis
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Lee S, Jeong YK, Lim JW, Kim H
- KMID: 2468813
- J Cancer Prev.
- 2019 Dec;24(4):233-239.
- doi: 10.15430/JCP.2019.24.4.233
BACKGROUND: Chronic pancreatitis (CP) is an irreversible progressive disease that destroys exocrine parenchyma, which are replaced by fibrous tissue. As pancreatic fibrosis is a key feature of CP, reducing fibrotic... -
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- Platycarya strobilacea leaf extract protects mice brain with focal cerebral ischemia by antioxidative property
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Lee JH, Jeong JH, Jeong YG, Kim DK, Lee NS, Na CS, Doh ES, Han SY
- KMID: 2466703
- Anat Cell Biol.
- 2019 Dec;52(4):486-497.
- doi: 10.5115/acb.19.141
The leaf extract of Platycarya strobilacea (PSL) has long been recognized as possessing various health-promoting activities. However, information on its possible protective effects against ischemic stroke is currently lacking. Here,... -
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