J Korean Soc Biol Psychiatry.  1999 Nov;6(2):149-152.

Animal Models of Alzheimer's Dementia

Abstract

Transgenic mice models of Alzheimer's disease were produced by overexpressing APP(amyloid precursor protein) mutant and presenilin mutant genes using the promotors that induced neuronal expression. The neuropathologies, electrophysiological changes and behavioral changes that were demonstrated in these transgenic mice model were amyloid changes, gliotic changes. A-beta increases, deficit in LTP(ling-term potentiation) and behavioral changes. Some or all of the above changes were found in each transgenic mice model. These models generally showed amyloid neuropathology but they usually lacked the neurofibrillary tangles. So, they can be regarded as partial models of Alzheimer's disease. The development of them is undoubtedly the great progress toward future research.


MeSH Terms

Alzheimer Disease
Amyloid
Animals*
Dementia*
Mice
Mice, Transgenic
Models, Animal*
Neurofibrillary Tangles
Neurons
Presenilins
Amyloid
Presenilins
Full Text Links
  • JKJBP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error