Sleep Med Psychophysiol.  2022 Jun;29(1):1-3. 10.14401/KASMED.2022.29.1.1.

Relationship Between Sleep and Alzheimer’s Dementia

• Lee KH
• Kim HC

• KMID: 2531149
• DOI: http://doi.org/10.14401/KASMED.2022.29.1.1

Abstract

Sleep is associated with Alzheimer’s dementia. Many previous researches have shown that inadequate sleep is one of the risk factors that predict Alzheimer’s dementia. The causal mechanism of this association is not clear. Slow wave sleep and REM sleep are critical stages in memory consolidation, and by sequential hypothesis both stages are important. Deposition of amyloid beta and tau, the main pathology of Alzheimer’s dementia, are also associated with sleep. This review provides the association of sleep and Alzheimer’s dementia, and future research is necessary to examine the specific mechanism of this association between sleep and Alzheimer’s dementia, which may lead to an early intervention in sleep.

Keyword

Alzheimer; Amyloid beta; Dementia; Sleep; Tau