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Imidacloprid inhibits IgE-mediated RBL-2H3 cell degranulation and passive cutaneous anaphylaxis

Shi L, Zou L, Gao J, Xu H, Shi X, Chen H

BACKGROUND: Imidacloprid has been commonly used as a pesticide for crop protection and acts as nicotinic acetylcholine receptor agonists. Little information about the relationship between imidacloprid and allergy is available. OBJECTIVE:...
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Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells

Jeong KT, Lee E, Park NY, Kim SG, Park HH, Lee J, Lee YJ, Lee E

Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse...
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Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway

Lu Y, Li X, Park YN, Kwon O, Piao D, Chang YC, Kim CH, Lee E, Son JK, Chang HW

  • KMID: 2170636
  • Biomol Ther.
  • 2014 May;22(3):193-199.
The aim of this study was to determine whether britanin, isolated from the flowers of Inula japonica (Inulae Flos), modulates the generation of allergic inflammatory mediators in activated mast cells....
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Molecular Genetic Mechanisms of Chronic Urticaria

Losol P, Yoo HS, Park HS

Chronic urticaria (CU) is a common allergic skin disease that requires long-term pharmacological treatment. Some patients with severe CU suffer a poor quality of life. Although the pathogenic mechanisms of...
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Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels

Li X, Lu Y, Jin Y, Son JK, Lee SH, Chang HW

  • KMID: 2048327
  • Biomol Ther.
  • 2014 Jan;22(1):27-34.
Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its...
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Effects of ATP and LTC4 on hypoxic pulmonary vasoconstriction in isolated rat lungs

Rho JY, Shin HY, Kim HC, Lee JW, Kim SD

BACKGROUND: Hypoxic pulmonary vasoconstriction (HPV) is unique to pulmonary circulation but the mechanism remains elusive. Red blood cells (RBCs) are known to augment HPV and to release more ATP as...
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Association study of polymorphism in leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes with phenotype of asthma and clinical parameters in Korean children

Shim JY, Kim BJ, Song YH, Kang MJ, Lee SY, Kim HB, Yu J, Hong SJ

PURPOSE: Cysteinyl leukotrienes are important proinflammatory mediators in asthma. Recently, it was suggested that a promoter polymorphism in the genes encoding for leukotriene C4 synthase (LTC4S), a key enzyme in...
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Association of Polymorphism in the Promoter Area of Leukotriene C4 Synthase Gene with Aspirin-Intolerant Asthma

  • KMID: 1850196
  • Korean J Asthma Allergy Clin Immunol.
  • 2006 Jun;26(2):115-121.
BACKGROUND: The 5-lipoxygenase, 5-lipoxygenase associated protein and leukotriene C4 (LTC4) synthase are enzymes involved in the synthesis of cysteinyl leukotrienes which are known to be important lipid mediators for the...
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Association of Leukotriene C4 Synthase Gene Polymorphism with Clinical Response to Montelukast in Childhood Asthma

Shin KS, Kim YW

  • KMID: 1855968
  • Korean J Pediatr.
  • 2005 Jul;48(7):766-771.
PURPOSE: Cysteinyl leukotrienes are important inflammatory mediators in the pathogenesis of asthma; therefore interruption of cysteinyl leukotrienes by leukotriene receptor antagonists improves clinical symptoms in the management of patients with...
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Leukotriene related gene polymorphisms in ASA-intolerant asthma: an association of 5-lipoxygenase haplotype

Choi JH, Park HS, Shin SS, Oh HB, Lee JH, Suh YJ, Park CS, Shin HD

  • KMID: 2178419
  • J Asthma Allergy Clin Immunol.
  • 2003 Dec;23(4):800-809.
BACKGROUND AND OBJECTIVES: A recent study has demonstrated a possible involvement of leukotriene C4 synthase (LTC4S) gene polymorphism in ASA-intolerant asthma (AIA) in a Polish population, while no significances were...
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Antagonism of Sophoricoside from Sophorica japonica on IL-5

Zhe YX, Kim Y, Jung SH, Lee SH, Ryu JC, Kim MK

  • KMID: 2285834
  • J Asthma Allergy Clin Immunol.
  • 2003 Sep;23(3):459-466.
BACKGROUND: Allergic disease is an inflammatory disease, whose main inflammatory cells are eosinophils, mast cells, and T lymphocytes. From that point, new therapeutic targets on allergic inflammation focusing on them...
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Antagonism of sophoricoside from sophorica japonica on GM-CSF-induced cosinophil activation

Yuan XZ, Kim Y, Jung SH, Lee SH, Ryu JC, Kim MK

  • KMID: 2285853
  • J Asthma Allergy Clin Immunol.
  • 2003 Jun;23(2):366-371.
BACKGROUND: allergic disease is an inflammatory disease, whose main inflammatory cells are eosinophils, mast cells, and T lymphocytes. From that point, new therapeutic targets on allergic inflammation focusing on them...
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Antagonism of new Flavonoids from Sophorica japonica on IL-3-induced eosinophil activation

Kim MK, Kim YS

  • KMID: 2054867
  • J Asthma Allergy Clin Immunol.
  • 2000 Oct;20(5):725-730.
BACKGROUND: Even though allergic disease is an inflammatory disease, main inflammatory cells and cytokines involved in this process are different from those in other inflammatory diseases. New therapeutic targets on...
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Effect of theophylline on urinary leukotriene B4 and C4 excretion in children with asthma

Chung HL, Lee JJ, Kim SG

  • KMID: 2054865
  • J Asthma Allergy Clin Immunol.
  • 2000 Oct;20(5):710-716.
BACKGROUND: Theophylline has been used in the treatment of asthma for decades as a broncho- dilator, but recent studies suggested that it has anti-inflammatory and immunomodulatory properties. OBJECTIVE: The aim...
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Leukotriene C4 synthase promoter polymorphism in aspirin - induced asthma

Cho JY, Lee SY, Han SA, Yoo SH, Kim SS, Park HS, Park JW, Hong CS, In KH

  • KMID: 2054840
  • J Asthma Allergy Clin Immunol.
  • 1999 Aug;19(4):542-547.
BACKGROUND: Aspirin/NSAIDs can release cysteinyl-leukotriene (cys-LTs) into airways and precipitate asthmatic symptoms in aspirin - induced asthma(AIA). It has been reported that there is profound overexpression of LTC4 synthase in...
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Effects of pranlukast on ovalbumin induced early-phase bronchoconstriction in guinea pigs

Lee SH, Shim JJ, Kim KK, Jeong HC, Kwon YH, Kim JH, Lee SY, Lee SR, Lee SY, Cho JY, In KH, Yoo SH, Kang KH

BACKGROUND: Leukotriene (LT) C4, D4, and E4, the main components of slow-reacting substance of anaphylaxis (SRS-A), have been suggested to play an important role in bronchial asthma such as antigen-...
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Arachidonic Acid Metabolites in Antrochoanal Polyp and the Nasal Polyp Associated with Chronic Paranasal Sinusitis

Rhee CK, Jang YJ

  • KMID: 2074329
  • Korean J Otolaryngol-Head Neck Surg.
  • 1999 Jan;42(1):54-57.
BACKGROUND AND OBJECTIVES: It is known that various inflammatory mediators released from the eosinophils and mast cells play important roles in the pathogenesis of nasal polyp. Among those mediators, the...
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Simultaneous HPLC analysis of arachidonic acid metabolites in biological samples with simple solid phase extraction

Kim HG, Huh YN, Park KS

  • KMID: 2071837
  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):779-786.
A reversed-phase high-performance liquid chromatography (RP-HPLC) has been developed to analyze the metabolites of arachidonic acid based on the specificities of ultraviolet absorption of these various metabolites and is sensitive to the nanogram...
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Mast Cells and Allergic Rhinitis

Cho JS

  • KMID: 2297727
  • J Rhinol.
  • 1998 Nov;5(2):85-91.
That mast cells play a role in acute allergic inflammation by releasing various inflammatory mediators, including histamine, leukotrienes (LT), such as LTC4 and LTD4, and prostaglandins (PG), such as PGD2,...
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Effect of the inhibition of PLA 2 on oxidative lung injury induced by interleukin-1alpha

Lee YM, Cho HG, Park YY, Kim JK, Lee YJ, Park WH, Kim T

  • KMID: 2071542
  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):617-628.
In order to understand the pathogenetic mechanism of adult respiratory distress syndrome (ARDS), the role of phospholipase A2 (PLA2) in association with oxidative stress was investigated in rats. Interleukin-1alpha (IL-1, 50 mug/rat) was...
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