Tuberc Respir Dis.
2003 Oct;55(4):378-387.
Aberrant Promoter Methylation of Death-Associated Protein Kinase in Serum DNA from Lung Cancer Patients
- Affiliations
-
- 1Department of Internal Medicine, Pusan National University College of medicine, Busan, Korea. leemk@pusan.ac.kr
- 2Medical Research Institute of Pusan National University Hospital, Busan, Korea.
Abstract
-
BACKGROUND: Promoter methylation of tumor suppressor genes is one of the key epigenetic changes in many human cancers. The aim of this study was to evaluate the promoter methylation status of the Death-associated protein(DAP) kinase gene, which played an important role in lung cancer, in the serum DNA of primary lung cancer patients.
METHODS
This study investigated the aberrant methylation of DAP kinase in the serum of 65 primary lung cancer patients by methylation-specific PCR (MSP).
RESULTS
Methylation in the serum was detected in 29 of 65(44.6%) for DAP kinase. There was no statistical association between methylation of DAP kinase and age, smoking history, histologic type, or stage. Methylation of DAP kinase was found more frequently in men (p=0.044).
CONCLUSIONS
This study suggests that the aberrant methylation of the DAP kinase promoter is readily detectable in the serum DNA of lung cancer patients using MSP analysis.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Aberrant Methylation of p16 Tumor Suppressor Gene and Death-Associated Protein Kinase in Non-Small Cell Lung Carcinoma
- Detection of Serum Free DNA Hypermethylation in Surgically Resected Adenocarcinoma of the Lung
- DNA Methylation in Lung Cancer
- AKAP12alpha is Associated with Promoter Methylation in Lung Cancer
- Correlation between Aberrant Promoter Hypermethylation of CpG Islands and the Clinical Outcome of Non-small Cell Lung Cancer after Curative Resection
