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Promoter-Specific Variants in NeuroD1 and H3K4me3 Coincident Regions and Clinical Outcomes of Small Cell Lung Cancer

Yoo SS, Lee S, Choi JE, Hong MJ, Do SK, Lee JH, Lee WK, Park JE, Lee YH, Choi SH, Seo H, Lee J, Lee SY, Cha SI, Kim CH, Kang HG, Park JY

Background: Neurogenic differentiation 1 (NeuroD1) is a representative small cell lung cancer (SCLC) transcription regulator involved in the carcinogenesis and behavior of SCLC. Histone modifications play an important role in transcription,...
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Perioperative immunotherapy in stage IB-III non-small cell lung cancer: a critical review of its rationale and considerations

Sim JK, Choi J, Lee SY

Lung cancer is a dismal disease as a leading cause of overall cancer death, but the development of immune checkpoint inhibitors (ICIs) in driver gene mutation negative metastatic non-small cell...
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99mTc-3PRGD2 SPECT/CT Imaging for Diagnosing Lymph Node Metastasis of Primary Malignant Lung Tumors

Xiao L, Yu S, Xu W, Sun Y, Xin J

Objective: To evaluate 99mtechnetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid ( 99mTc-3PRGD2) singlephoton emission computed tomography (SPECT)/computed tomography (CT) imaging for diagnosing lymph node metastasis of primary malignant lung neoplasms. Materials and Methods:...
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Determinants of Willingness to Undergo Lung Cancer Screening among High- Risk Current and Ex-smokers in Sabah, Malaysia: A Cross-Sectional Pilot Study

Nyanti LE, Chua CZ, Loo HC, Khor CZ, Toh ESY, Gill RS, Chan ET, Tan KY, Rosli T, Rahim MAA, Ibrahim A, Huan NC, Ramarmuty HYD, Kannan KKS

Background: Attitudes towards smoking, lung cancer screening, and perceived risk of lung cancer have not been widely studied in Malaysia. The primary objective of this study was to describe the...
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Antimetastatic effect of fucoidan against non-small cell lung cancer by suppressing non-receptor tyrosine kinase and extracellular signalrelated kinase pathway

Muneerungsee N, Tanasawet S, Sukketsiri W

BACKGROUND/OBJECTIVES: Fucoidan, a polysaccharide content in brown algae, has been reported to inhibit the growth of cancer cells. The present study aimed to investigate the suppression effects of fucoidan on...
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Immune Regulatory Function of Cancer- Associated Fibroblasts in Non-small Cell Lung Cancer

Lee H, Hwang M, Jang S, Um SW

Background: Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment and significantly contribute to immune evasion. We investigated the effects of CAFs on the immune function of CD4+ and...
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Subtype-Based Microbial Analysis in Non-small Cell Lung Cancer

Jang HJ, Lee E, Cho YJ, Lee SH

Background: The human lung serves as a niche for a unique and dynamic bacterial community related to the development and aggravation of multiple respiratory diseases. Therefore, identifying the microbiome status...
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Influence of Two-Dimensional and Three-Dimensional Acquisitions of Radiomic Features for Prediction Accuracy

i Fukui R, Matsuura R, Kida K, Goto S

Purpose: In radiomics analysis, to evaluate features, and predict genetic characteristics and survival time, the pixel values of lesions depicted in computed tomography (CT) and magnetic resonance imaging (MRI) images...
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Outcome of dose-escalated intensity-modulated radiotherapy for limited disease small cell lung cancer

Yang E, Shin YS, Joo JH, Choi W, Kim SS, Choi EK, Lee J, Song SY

Purpose: An optimal once-daily radiotherapy (RT) regimen is under investigation for definitive concurrent chemoradiotherapy (CCRT) in limited disease small cell lung cancer (LD-SCLC). We compared the efficacy and safety of...
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Comparison between 1-week and 2-week palliative radiotherapy courses for superior vena cava syndrome

Park J, Lee JE

Purpose: The aim of this study was to evaluate the effectiveness of palliative radiation therapy (RT) for superior vena cava (SVC) syndrome from lung cancer and to compare the 2-week...
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Analysis of the Spread of Misinformation about Lung Cancer on YouTube: Based on Source of Information

Park H, Kang E, Kim Y, Ju H

Background: Lung cancer has a high global incidence and mortality rate. Proper screening, prevention, and early treatment of high-risk groups are important for lung cancer. Therefore, it is important for...
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Exploring the past, present, and future of postoperative radiotherapy for N2 stage non-small cell lung cancer

Kim BH, Kim JS, Kim HJ

Despite conventionally applied postoperative radiotherapy (PORT) in pathological N2 (pN2) stage non-small cell lung cancer (NSCLC) considering high locoregional recurrence, its survival benefit has been a continuous topic of debate....
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Cancer-Related Dysfunctional Beliefs About Sleep Mediate the Influence of Sleep Disturbance on Fear of Progression Among Patients With Surgically Resected Lung Cancer

Kim H, Ji W, Lee JW, Jo MW, Yun SC, Lee SW, Choi CM, Lee GD, Lee HJ, Cho E, Lee Y, Chung S

Background: Lung cancer is associated with significant psychological distress, including fear of progression (FoP). Because insomnia and depression are highly prevalent and associated with FoP, we examined the association between...
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Effect of total intravenous versus inhalation anesthesia on long-term oncological outcomes in patients undergoing curative resection for early-stage non-small cell lung cancer: a retrospective cohort study

Seo KH, Hong JH, Moon MH, Hwang W, Lee SW, Chon JY, Kwon H, Hong SH, Kim S

Background: Propofol-based total intravenous anesthesia (TIVA) improves long-term outcomes after cancer surgery compared with inhalation anesthesia. However, its effect on patients undergoing non-small cell lung cancer (NSCLC) surgery remains unclear....
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Problems in the Pathologic Diagnosis of Suspected Lung Cancer

Kim SH, Kim MH, Lee MK, Eom JS

Since the introduction of low-dose computed tomography (CT) screening for patients at high risk of lung cancer, the detection rate of suspicious lung cancer has increased. In addition, there have...
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Prediction of Postoperative Lung Function in Lung Cancer Patients Using Machine Learning Models

Kwon OB, Han S, Lee HY, Kang HS, Kim SK, Kim JS, Park CK, Lee SH, Kim SJ, Kim JW, Yeo CD

Background: Surgical resection is the standard treatment for early-stage lung cancer. Since postoperative lung function is related to mortality, predicted postoperative lung function is used to determine the treatment modality....
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Combination of the LARS1 Inhibitor, BC-LI-0186 with a MEK1/2 Inhibitor Enhances the Anti-Tumor Effect in Non–Small Cell Lung Cancer

Lee SH, Kim EY, Han JM, Han G, Chang YS

Purpose The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth and proliferation by growth factor coordination and amino acid availability. Leucyl-tRNA synthetase 1 (LARS1) senses the intracellular leucine...
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Diagnostic Performance of Endosonography to Detect Mediastinal Lymph Node Metastasis in Patients with Radiological N1 Non–Small Cell Lung Cancer

Kim BG, Cho JH, Shin SH, Lee K, Um SW, Kim H, Kim J, Shim YM, Jeong BH

Purpose Guidelines recommend that non–small cell lung cancer (NSCLC) patients with suspected hilar lymph node (LN) metastases should undergo invasive mediastinal LN staging prior to surgical treatment via endosonography. We...
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MLL4 Regulates the Progression of Non–Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis

Yang Y, Qiu R, Weng Q, Xu Z, Song J, Zhao S, Meng M, Zhang D, Kong C, Wang H, Xu M, Zhao Z, Ji J

Purpose Mixed-lineage leukemia protein 4 (MLL4/KMT2D) is a histone methyltransferase, and its mutation has been reported to be associated with a poor prognosis in many cancers, including lung cancer. We...
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Genomic Characteristics and the Potential Clinical Implications in Oligometastatic Non–Small Cell Lung Cancer

Liao R, Chen K, Li J, He H, Yi G, Huang M, Chen R, Shen L, Zhang X, Xu Z, Yang Z, Peng Y

Purpose Oligometastatic non–small cell lung cancer (NSCLC) patients have been increasingly regarded as a distinct group that could benefit from local treatment to achieve a better clinical outcome. However, current...
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