- Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes
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Lee J, Jang A, Seo SJ, Myung SC
- KMID: 2471338
- Ann Dermatol.
- 2020 Apr;32(2):122-129.
- doi: 10.5021/ad.2020.32.2.122
BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor... -
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- Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis
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Liu Z, Chen J, Cheng L, Li H, Liu S, Lou H, Shi J, Sun Y, Wang D, Wang C, Wang X, Wei Y, Wen W, Yang P, Yang Q, Zhang G, Zhang Y, Zhao C, Zhu D, Zhu L, Chen F, Dong Y, Fu Q, Li J, Li Y, Liu C, Liu F, Lu M, Meng Y, Sha J, She W, Shi L, Wang K, Xue J, Yang L, Yin M, Zhang L, Zheng M, Zhou B, Zhang L
- KMID: 2468459
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):176-237.
- doi: 10.4168/aair.2020.12.2.176
The current document is based on a consensus reached by a panel of experts from the Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck Surgery, Rhinology... -
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- Advances in urinary biomarker discovery in urological research
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Kim J, Kim WT, Kim WJ
- KMID: 2469122
- Investig Clin Urol.
- 2020 Feb;61(Suppl 1):S8-S22.
- doi: 10.4111/icu.2020.61.S1.S8
A disease-specific biomarker (or biomarkers) is a characteristic reflecting a pathological condition in human body, which can be used as a diagnostic or prognostic tool for the clinical management. A... -
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- Epigenetic Changes in Asthma: Role of DNA CpG Methylation
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Bae DJ, Jun JA, Chang HS, Park JS, Park CS
- KMID: 2466615
- Tuberc Respir Dis.
- 2020 Jan;83(1):1-13.
- doi: 10.4046/trd.2018.0088
For the past three decades, more than a thousand of genetic studies have been performed to find out the genetic variants responsible for the risk of asthma. Until now, all... -
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- Circulating MicroRNAs and T-Cell Cytokine Expression Are Associated With the Characteristics of Asthma Exacerbation
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Wardzyńska A, Pawełczyk M, Rywaniak J, Kurowski M, Makowska J, Kowalski M
- KMID: 2462577
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):125-136.
- doi: 10.4168/aair.2020.12.1.125
PURPOSE: Immunological mechanisms underlying asthma exacerbation have not been elucidated. The aim of this study was to assess the associations of various asthma exacerbation traits with selected serum microRNA (miRNA)... -
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- DNA methylation: a cause and consequence of type 2 diabetes
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Kim M
- KMID: 2468864
- Genomics Inform.
- 2019 Dec;17(4):e38.
- doi: 10.5808/GI.2019.17.4.e38
DNA methylation is a relatively stable epigenetic modification that can regulate and stabilize gene expression patterns and hence establish cell identity. Because metabolic intermediates are key factors of DNA methylation... -
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- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells
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Kim D, Kim Y, Kim Y
- KMID: 2468812
- J Cancer Prev.
- 2019 Dec;24(4):224-232.
- doi: 10.15430/JCP.2019.24.4.224
BACKGROUND: Beta-carotene (BC) is a carotenoid which exerts anti-cancer effects in several types of cancer, including colorectal cancer. Epigenetic modifications of genes, such as histone deacetylation and DNA hypermethylation, have... -
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- Methyl-CpG Binding Protein 2 in Alzheimer Dementia
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Kim B, Choi Y, Kim HS, Im HI
- KMID: 2467315
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S72-S81.
- doi: 10.5213/inj.1938196.098
Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp. Methyl-CpG Binding Protein 2 (MeCP2)... -
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- Complementary Participation of Genetics and Epigenetics in Development of NSAID-exacerbated Respiratory Disease
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Lee JU, Park JS, Chang HS, Park CS
- KMID: 2459183
- Allergy Asthma Immunol Res.
- 2019 Nov;11(6):779-794.
- doi: 10.4168/aair.2019.11.6.779
Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) has attracted a great deal of attention because of its association with severe asthma. However, it remains widely underdiagnosed in asthmatics as well... -
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- The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms
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Lee HS
- KMID: 2462038
- Genomics Inform.
- 2019 Sep;17(3):e24.
- doi: 10.5808/GI.2019.17.3.e24
Early environmental exposure is recognized as a key factor for long-term health based on the Developmental Origins of Health and Disease hypothesis. It considers that early-life nutrition is now being... -
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- Epigenetics and Depression: An Update
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Lin E, Tsai SJ
- KMID: 2459685
- Psychiatry Investig.
- 2019 Sep;16(9):654-661.
- doi: 10.30773/pi.2019.07.17.2
OBJECTIVE: Depression is associated with various environmental risk factors such as stress, childhood maltreatment experiences, and stressful life events. Current approaches to assess the pathophysiology of depression, such as epigenetics... -
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- RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia
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Park JH, Lee TK, Kim DW, Park CW, Park YE, Kim B, Lee JC, Lee HA, Won MH, Ahn JH
- KMID: 2470111
- Lab Anim Res.
- 2019 Aug;35(2):78-85.
- doi: 10.1186/s42826-019-0011-3
Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion injury. In the... -
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- HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice
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Kim T, Song S, Park Y, Kang S, Seo H
- KMID: 2458548
- Exp Neurobiol.
- 2019 Aug;28(4):504-515.
- doi: 10.5607/en.2019.28.4.504
Parkinson’s disease (PD) is one of the late-onset neurodegenerative movement disorder. Major pathological markers of PD include progressive loss of dopaminergic neurons, Lewy body formation, genetic mutations, and environmental factors.... -
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- Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs
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Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F
- KMID: 2455043
- Tissue Eng Regen Med.
- 2019 Aug;16(4):335-343.
- doi: 10.1007/s13770-018-0172-4
BACKGROUND: Osteoarthritis (OA) is a highly prevalent degenerative joint disease involving joint cartilage and its surrounding tissues. OA is the leading cause of pain and disability worldwide. At present, there... -
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- Angiotensin II and TGF-β1 Induce Alterations in Human Amniotic Fluid-Derived Mesenchymal Stem Cells Leading to Cardiomyogenic Differentiation Initiation
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GasiÅ«nienÄ— M, Petkus G, MatuzeviÄius D, Navakauskas D, NavakauskienÄ— R
- KMID: 2465896
- Int J Stem Cells.
- 2019 Jul;12(2):251-264.
- doi: 10.15283/ijsc18126
BACKGROUND AND OBJECTIVES: Human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) may be a valuable source for cardiovascular tissue engineering and cell therapy. The aim of this study is to verify... -
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- PM(2.5) and pediatric asthma
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Hwang YH, Kim SW
- KMID: 2461403
- Allergy Asthma Respir Dis.
- 2019 Jul;7(3):116-121.
- doi: 10.4168/aard.2019.7.3.116
Air pollution does harm to the respiratory tracts. Fine particulate matter (PM(2.5)) attacks the lung directly passing through mucosal ciliary clearance, causes new-onset asthma, or exacerbates asthma symptoms in children.... -
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- 4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages
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Yoo OK, Keum YS
- KMID: 2455093
- Biomol Ther.
- 2019 Jul;27(4):381-385.
- doi: 10.4062/biomolther.2018.232
We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage... -
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- The Effect of Breastfeeding on Prevention of Maternal Hypertension: Systematic Review
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Jeon H, Joo SH, Choi A, Han JY, Jeong ES, Shin HJ, Kim JY
- KMID: 2454968
- J Korean Soc Matern Child Health.
- 2019 Jul;23(3):185-190.
- doi: 10.21896/jksmch.2019.23.3.185
PURPOSE: The purpose of this study is to clarify the relevance of breastfeeding and its preventive effect on maternal hypertension as well as to evaluate the theoretical mechanism behind of... -
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- Role of DNA Methylation in the Development and Differentiation of Intestinal Epithelial Cells and Smooth Muscle Cells
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Jorgensen , Ro S
- KMID: 2454636
- J Neurogastroenterol Motil.
- 2019 Jul;25(3):377-386.
- doi: 10.5056/jnm19077
The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has... -
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- House Dust Mite Allergy Under Changing Environments
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Acevedo N, Zakzuk J, Caraballo
- KMID: 2448749
- Allergy Asthma Immunol Res.
- 2019 Jul;11(4):450-469.
- doi: 10.4168/aair.2019.11.4.450
Environmental variations induced by industrialization and climate change partially explain the increase in prevalence and severity of allergic disease. One possible mechanism is the increase in allergen production leading to... -
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