J Bone Metab.  2018 Feb;25(1):9-13. 10.11005/jbm.2018.25.1.9.

Trans-differentiation via Epigenetics: A New Paradigm in the Bone Regeneration

Affiliations
  • 1Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea. hmryoo@snu.ac.kr
  • 2Department of Periodontology, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea.

Abstract

In regenerative medicine, growing cells or tissues in the laboratory is necessary when damaged cells can not heal by themselves. Acquisition of the required cells from the patient's own cells or tissues is an ideal option without additive side effects. In this context, cell reprogramming methods, including the use of induced pluripotent stem cells (iPSCs) and trans-differentiation, have been widely studied in regenerative research. Both approaches have advantages and disadvantages, and the possibility of de-differentiation because of the epigenetic memory of iPSCs has strengthened the need for controlling the epigenetic background for successful cell reprogramming. Therefore, interest in epigenetics has increased in the field of regenerative medicine. Herein, we outline in detail the cell trans-differentiation method using epigenetic modification for bone regeneration in comparison to the use of iPSCs.

Keyword

Bone regeneration; Cell transdifferentiation; Epigenomics; Induced pluripotent stem cells; Tissue engineering

MeSH Terms

Bone Regeneration*
Cell Transdifferentiation
Cellular Reprogramming
Epigenomics*
Induced Pluripotent Stem Cells
Memory
Methods
Regenerative Medicine
Tissue Engineering
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