Korean J Bone Metab.
2011 May;18(1):1-8.
Bone Regeneration from Adipose Stem Cells
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- 1Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, South Korea. gunil@duih.org
Abstract
- Reconstruction of large bone defect poses a great challenge to an orthopedic surgeon. Recent advancement in stem cell research ushered the treatment of bone defect with tissue-engineered bone into near-possibility. While adipose stem cells (ASCs) are the most available cell sources for tissue regeneration, their low osteogenic potential is a disadvantage. Several strategies have been developed to enhance the osteogenic differentiation of ASCs. In this review, we summarized literatures and our experience on the technology to promote osteogenesis from ASCs.
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