J Korean Orthop Assoc.  2019 Dec;54(6):490-497. 10.4055/jkoa.2019.54.6.490.

Clinical Use of Mesenchymal Stem Cells in Bone Regeneration

  • 1Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. limsj70@gmail.com


Owing to the recent advances in biological knowledge on stem cells, many efforts are being made to apply them to clinical practice. Although mesenchymal stem cells were first found in bone marrow aspirates, they are understood to be multipotent stromal cells that can be extracted from a variety of tissues, such as adipose, dermal, skeletal muscle, and umbilical-cord tissues. The osteogenicity of mesenchymal stem cells has been verified through various experiments and animal studies. Some successful bone regenerations have also been reported in difficult clinical situations, such as large bone defects, osteonecrosis, and nonunion. On the other hand, there are no standardized indications or application methods for each clinical situation, and convincing evidence of its efficacy and safety is still lacking. Bone regeneration therapies using mesenchymal stem cells are likely to expand further in the future, but there are some issues that need to be addressed in order for them be recognized as standard treatments.


mesenchymal stem cell; bone regeneration; bone marrow; osteonecrosis; nonunion

MeSH Terms

Bone Marrow
Bone Regeneration*
Mesenchymal Stromal Cells*
Muscle, Skeletal
Stem Cells
Stromal Cells
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