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Overcoming Current Dilemma in Cartilage Regeneration: Will Direct Conversion Provide a Breakthrough?

Im Gi, Kim TK

Direct reprogramming/direct conversion/transdifferentiation is a process that induces conversion between completely different matured (differentiated) cells in higher organisms. Unlike the process of reprogramming of differentiated cells into induced pluripotent stem...
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Stem Cells for the Regeneration of Tendon and Ligament: A Perspective

Im GI, Kim TK

Tendons are structures that connect muscles to the bones in our body and transmit the force generated by contraction of the muscles to the bones. Ligaments are structures that connect...
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Regenerative Therapy for Osteoarthritis: A Perspective

Im GI, Kim TK

Osteoarthritis (OA) is the most common type of arthritis and causes a significant deterioration in patients’ quality of life. The high prevalence of OA as well as the current lack...
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Overviews on the Clinical Use of Stem Cells in Orthopaedics

Im GI

Stem cell research arose from the need to explore new therapeutic possibilities for intractable and lethal diseases. Although musculoskeletal disorders are basically nonlethal, their high prevalence and the relative ease...
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Perspective on Intra-articular Injection Cell Therapy for Osteoarthritis Treatment

Im GI

BACKGROUND: Osteoarthritis (OA), the most common arthritis, is one of the most frequently encountered orthopaedic conditions. As a small number of large joints such as knee and hip are affected...
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Updates in Cartilage Tissue Regeneration

Im GI, Cho CS

No abstract available.
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Stem Cell Therapy in Osteonecrosis of the Femoral Head

Im GI

No abstract available.
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Effects of Trichostatin A on the Chondrogenesis from Human Mesenchymal Stem Cells

Lee J, Im GI

Histone deacetylase inhibitors (HDACi) are a class of compounds that suppress the function of histone deacetylases (HDACs). This study was performed to examine the effects of Trichostatin A (TSA), a...
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Intra-articular Xenotransplantation of Adipose-Derived Stromal Cells to Treat Osteoarthritis in a Goat Model

Ko JY, Lee J, Lee J, Im GI

Adipose-derived stromal cells (ASCs) have been investigated as a cell source for tissue regeneration. The purpose of this study was first to confirm if medial meniscectomy induces osteoarthritis (OA) in...
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Effect of Teriparatide on Healing of Atypical Femoral Fractures: A Systemic Review

Im GI, Lee SH

BACKGROUND: Bisphosphonates (BPs) are the most commonly used anti-osteoporotic drugs, which have been proven to reduce the risk of osteoporotic fractures. However, use of BPs, particularly for long periods of...
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Pathogenesis, Management and Prevention of Atypical Femoral Fractures

Im GI, Jeong SH

Much attention has been paid to the relationship between atypical femoral fractures (AFF) and use of bisphosphonates (BPs). While a significant cause-effect relationship was not established in earlier studies, more...
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The Relationship between Osteoarthritis of the Knee and Bone Mineral Density of Proximal Femur: A Cross-Sectional Study from a Korean Population in Women

Im GI, Kwon OJ, Kim CH

BACKGROUND: The relationship between osteoarthritis (OA) and osteoporosis (OP) is complicated and it may differ according to the site or stage of disease. The purpose of this cross-sectional study is...
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Current Status of Basic Research in Orthopaedics

Im GI

Orthopaedic medicine has developed and benefited from the advancement of related basic science. Current technologies such as joint replacement and internal fixation of fractures started from research on biocompatible biomaterials...
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Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study

Park JC, Lee JB, Daculsi G, Oh SY, Cho KS, Im GI, Kim BS, Kim CS

PURPOSE: The osseointegration around titanium mini-implants installed in macroporous biphasic calcium phosphate (MBCP) blocks was evaluated after incubation with recombinant human bone morphogenetic protein-2 (rhBMP-2) in an ectopic subcutaneous rat...
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Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma

Yang HS, Shin J, Bhang SH, Shin JY, Park J, Im GI, Kim CS, Kim BS

Platelet-rich plasma (PRP) contains growth factors that promote tissue regeneration. Previously, we showed that heparin-conjugated fibrin (HCF) exerts the sustained release of growth factors with affinity for heparin. Here, we...
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The Usefulness of Bone Turnover Marker as a Predictive Factor In Osteopenic Postmenopausal Women

Koo KH, Back YW, Im GI

  • KMID: 2199042
  • J Korean Orthop Res Soc.
  • 2011 Jun;14(1):17-23.
PURPOSE: To assess the relationship between biochemical bone turnover marker and bone mineral density(BMD) and to evaluate the predictive role of biochemical bone marker in postmenopausal osteopenic woman. MATERIALS AND METHODS:...
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The Correlations of the Radiological Parameters of Hip Dysplasia and Proximal Femoral Deformity in Clinically Normal Hips of a Korean Population

Park JM, Im GI

BACKGROUND: The aim of this study was to answer the following two questions: 1) Do the radiological parameters of dysplasia have significant correlations between themselves or with the parameters of...
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Bone Regeneration from Adipose Stem Cells

Im GI, Lee JS

  • KMID: 2300154
  • Korean J Bone Metab.
  • 2011 May;18(1):1-8.
Reconstruction of large bone defect poses a great challenge to an orthopedic surgeon. Recent advancement in stem cell research ushered the treatment of bone defect with tissue-engineered bone into near-possibility....
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Update in Tissue Engineering Methods for Meniscal Tear of knee Joint

An JH, Yang JY, Im GI

  • KMID: 2104930
  • J Korean Orthop Res Soc.
  • 2009 Jun;12(1):19-24.
Meniscal tear of knee joint has been known to be one of the most important risk factors to cause knee osteoarthritis. For meniscal tear, in vascular peripheral zone meniscal repair...
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Evaluation of the Hip

Im GI, Tae SK, Oh JS, Kim JY

The hip is a true ball and socket joint. The hip joint is held in place with ligaments, tendons, and muscles. It is surrounded by a series of bursae which...
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