Psychiatry Investig.  2010 Dec;7(4):278-284.

Bone Density in Chronic Schizophrenia with Long-Term Antipsychotic Treatment: Preliminary Study

Affiliations
  • 1National Naju Hospital, Naju, Korea.
  • 2Department of Psychiatry, Seoul Veterans Hospital, Seoul, Korea. vetmoon@kornet.net

Abstract


OBJECTIVE
Decreased bone mineral density has been found in the chronic schizophrenic patients who have been given a long-term administration of antipsychotics. Hyperprolactinemia from the antipsychotics and the negative symptom of schizophrenia were considered as the causes for this finding. In this study, the effect of hyperprolactinemia and the negative symptom of schizophrenia on bone mineral density was investigated on male schizophrenic patients.
METHODS
The cross-sectional study was carried out with the subjects of 45 male schizophrenic patients who have undertaken the monotherapy with risperidone, olanzapine and clozapine for at least one year. The demographic factors, clinical symtoms, bone mineral density and hematological test were examined for all the subjects.
RESULTS
No significant relationship was found between hyperprolactinemia and the decreased bone mineral density in the subjects. The negative schizophrenia symptom of the subjects showed a significant effect on the decreased bone mineral density.
CONCLUSION
The decreased bone mineral density finding in the male schizophrenic patients may be caused by the negative schizophrenia symptom rather than the hyperprolactinemia due to the antipsychotics. Additional studies are further required regarding other factors that may affect the decreased bone mineral density such as activity, calcium intake and exposure to sunlight.

Keyword

Bone density; Hyperprolactinemia; Schizophrenia; Negative symptoms; Antipsychotics

MeSH Terms

Antipsychotic Agents
Benzodiazepines
Bone Density
Calcium
Clozapine
Cross-Sectional Studies
Demography
Hematologic Tests
Humans
Hyperprolactinemia
Male
Risperidone
Schizophrenia
Sunlight
Antipsychotic Agents
Benzodiazepines
Calcium
Clozapine
Risperidone
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