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Updates on the Diagnosis and Treatment of Restless Legs Syndrome

Kang SG

Restless legs syndrome (RLS) is a neurological sleep disorder characterized by an urge to move the legs or arms and is associated with discomfort and paresthesia in the legs. RLS...
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Midazolam use in pediatric dentistry: a review

Jain SA, Rathi N, Thosar N, Baliga S

Behaviour management and dental procedures performed in very young, pre-cooperative, highly anxious, or medically disabled children are challenging tasks. Various drugs and methods have, however, been introduced to facilitate treatment...
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Stiff-Person Syndrome: Diagnostic Difficulty

Lee JK, Kang C, Kim SB, An BK, Lee GS

Stiff-person syndrome is a rare disorder, and the natural history of the syndrome has not been completely ascertained. The symptoms range from mild to severe and can progress over time:...
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Comorbid Zolpidem Dependence and Over-the-Counter Compound Analgesic Abuse

Kim H, Shin C, Ko YH, Han C

Zolpidem is a commonly prescribed hypnotic used to treat insomnia. However, its potential for abuse and dependence has recently become controversial. Although over-the-counter (OTC) medications are widely used, their abuse...
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Metoprolol treatment of dual cocaine and bupropion cardiovascular and central nervous system toxicity

Richards J, Gould JB, Laurin EG, Albertson

Cardiovascular and central nervous system (CNS) toxicity, including tachydysrhythmia, agitation, and seizures, may arise from cocaine or bupropion use. We report acute toxicity from the concomitant use of cocaine and...
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The Evaluation of Drug Utilization Review on Potentially Inappropriate Medications for Elderly Patients in a Tertiary Hospital

Cho YH, Kim KJ

OBJECTIVE: South Korea made a list of potentially inappropriate medications (PIMs) for elderly patients in 2015 and has prompted medical professionals to prescribe proper medication by using the drug utilization...
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Clinical Features Affecting Antipsychotic Prescription for Delirium Patients

Kim J, Kim MH, Paik SH

OBJECTIVES: The purpose of this study was to investigate the clinical characteristics of antipsychotic medication prescription for the symptom control in patients with delirium. METHODS: One hundred and eighty-five patients referred...
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Development of Safety Usage Guidelines for Sedative Hypnotics Using the Delphi Technique

Nam YJ, Cho CH, Lee Y, Lee HJ

OBJECTIVES: The objective of this study was to develop evidence- and consensus-based clinical safety usage guidelines for sedative hypnotics using the Delphi technique. METHODS: A group of 15 sleep experts from...
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Clinical Efficacy and Safety of Injectable Levetiracetam Versus Phenytoin as Second-Line Therapy in the Management of Generalized Convulsive Status Epilepticus in Children: An Open-Label Randomized Controlled Trial

Noureen N, Khan S, Khursheed , Iqbal I, Maryam M, Sharib SM, Maheshwary N

BACKGROUND AND PURPOSE: There is sparsity of quality evidence for the use of drugs after first-line benzodiazepines in convulsive status epilepticus in children. The aim of the study was to...
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Korean Treatment Guideline on Pharmacotherapy of Co-existing Symptoms and Antipsychotics-related Side Effects in Patients with Schizophrenia

Yun JY, Lee JS, Kang SH, Nam B, Lee SJ, Lee SH, Choi J, Kim CH, Chung YC

OBJECTIVES: The current study covers a secondary revision of the guidelines for the pharmacotherapy of schizophrenia issued by the Korean Medication Algorithm for Schizophrenia (KMAP-SCZ) 2001, specifically for co-existing symptoms...
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Risk of Dementia in Long-Term Benzodiazepine Users: Evidence from a Meta-Analysis of Observational Studies

He Q, Chen X, Wu T, Li L, Fei X

BACKGROUND AND PURPOSE: There is conflicting evidence in the literature on the association between benzodiazepines (BDZs) and the risk of dementia. This meta-analysis aimed to determine the relationship between the...
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Development of a Consensus List of Potentially Inappropriate Medications for Korean Older Adults

Kim MY, Etherton-Beer C, Kim CB, Yoon JL, Ga H, Kim HC, Song JS, Kim KI, Won CW

BACKGROUND: Korea has recently attained the aged society status and the growth rate of the aging population will be among the most rapid worldwide. The objective of this study was...
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Benzodiazepine-Associated Carcinogenesis: Focus on Lorazepam-Associated Cancer Biomarker Changes in Overweight Individuals

Ku SC, Ho PS, Tseng YT, Yeh TC, Cheng SL, Liang CS

OBJECTIVE: Cellular, animal, and human epidemiological studies suggested that benzodiazepines increase the risk of cancer and cancer mortality. Obesity is also clearly linked to carcinogenesis. However, no human studies have...
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Successful Management of Clozapine-induced Akathisia with Gabapentin Enacarbil: A Case Report

Takeshima , Ishikawa H, Kikuchi Y, Kanbayashi T, Shimizu T

The management of clozapine (CLZ)-induced adverse events affects patient prognoses. Akathisia is a relatively rare adverse event related to CLZ administration and thus the management of this syndrome is not...
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A Systematic Review and Meta-analysis on the Effect of Herbal Medicine to Manage Sleep Dysfunction in Peri- and Postmenopause

Khadivzadeh T, Abdolahian S, Ghazanfarpour M, Kargarfard L, Dizavandi , Khorsand I

OBJECTIVES: Some conventional medications used to treat insomnia, such as benzodiazepine, non-benzodiazepine, and hormone therapy, are associated with side effects. Therefore, there is a growing interest in the use of...
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Sleep-Aids Derived from Natural Products

Hu Z, Oh S, Ha TW, Hong JT, Oh KW

Although drugs such as barbiturates and benzodiazepines are often used for the treatment of insomnia, they are associated with various side effects such as habituations, tolerance and addiction. Alternatively, natural...
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Use of hypnotics and the risk of or mortality from heart disease: a meta-analysis of observational studies

Kim YH, Kim HB, Kim DH, Kim JY, Shin HY

BACKGROUND/AIMS: Some observational epidemiologic studies have reported conflicting results on the relationship between hypnotics use and the risk of developing and/or dying from heart disease. We investigated these associations using...
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Updates on the Treatment of Restless Legs Syndrome

Kang SG

Restless legs syndrome (RLS) is a sleep disorder characterized by an urge to move the legs or arms and uncomfortable paresthesia in the legs. Treatment of RLS can be various...
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The Changes of Sedation in the Department of Pediatric Dentistry, Yonsei University Dental Hospital

Lee K, Song JS, Kim SO, Lee J, Choi B, Choi HJ

Sedation is a useful behavior management technique for dental patients who may be uncontrollable or have medical problems. The aim of this study is to investigate the changes in patterns...
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Assessment of Switching to Suvorexant versus the Use of Add-on Suvorexant in Combination with Benzodiazepine Receptor Agonists in Insomnia Patients: A Retrospective Study

Hatano M, Kamei H, Inagaki R, Matsuzaki , Hanya M, Yamada S, Iwata N

OBJECTIVE: Suvorexant is a novel hypnotic drug that does not interact with the conventional γ-aminobutyric acid (GABA)-A receptor. We investigated the method by which suvorexant was introduced in insomnia patients...
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