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Switching Antipsychotics to Blonanserin in Patients with Schizophrenia: An Open-label, Prospective, Multicenter Study

Woo YS, Yoon BH, Jeon BH, Seo JS, Nam B, Lee SY, Jae YM, Jang SH, Eun HJ, Won SH, Lee K, Lee J, Bahk WM

OBJECTIVE: This study was performed to investigate the efficacy and tolerability of blonanserin in schizophrenic patients who were previously treated with other antipsychotics but, due to insufficient response, were switched...
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Serum Prolactin and Bone Mineral Density in Schizophrenia: A Systematic Review

Lally J, Sahl AB, Murphy KC, Gaughran F, Stubbs B

The relationship between serum prolactin and bone mineral density (BMD) in schizophrenia is unclear. We conducted a literature review of databases from inception until December 2018 for cross-sectional, case-control, prospective...
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Macroprolactinoma in a young man presenting with erectile dysfunction

Song SH, Lee J, Kim DS

Hyperprolactinemia due to a pituitary adenoma is a rare cause of erectile dysfunction (ED). The prevalence of clinically apparent prolactinomas is reported to be from 6–10 to 50 per 100,000....
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Amenorrhea as a Side Effect of Low Dose Aripiprazole: An Adolescent Case

Guler G, Kutuk MO, Kara H

Amenorrhea, oligomenorrhea, galactorrhoea, gynecomastia, infertility, and sexual dysfunction may arise as a consequence of hyperprolactinemia. Hyperprolactinemia is one of major side effects of treatment with antipsychotics, but aripiprazole is known...
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Hyperprolactinemia after taking Levosulpiride and its Causality Assessment: An Adverse Event Reported by a Community Pharmacy

Lee H, Jo YJ, Yoon JS, Ji E

Levosulpiride is one of the most frequently prescribed medicines in Korea. An adverse drug reaction (ADR) after taking levosulpiride was reported at a community pharmacy in Korea. A 31-year-old woman...
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Korean Medication Algorithm for Bipolar Disorder 2018 : Safety and Tolerability

Sohn I, Bahk WM, Yoon BH, Jon DI, Seo JS, Kim W, Lee JG, Woo YS, Jeong JH, Kim MD, Jung YE, Shim SH, Song HR, Min KJ

OBJECTIVES: Treatment for bipolar disorder is often complicated by various clinical situations. We undertook a survey of expert opinions to facilitate clinical decisions in special situations such as weight gain,...
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Serum Prolactin Levels in Patients with Major Depressive Disorder Receiving Selective Serotonin-Reuptake Inhibitor Monotherapy for 3 Months: A Prospective Study

Park YM

OBJECTIVE: It is unclear whether selective serotonin-reuptake inhibitors (SSRIs) can significantly increase the prolactin level. The purpose of this study was to identify the relationship between the prolactin level and...
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Growth without growth hormone in combined pituitary hormone deficiency caused by pituitary stalk interruption syndrome

Lee SS, Han AL, Ahn MB, Kim SH, Cho WK, Cho KS, Park SH, Jung MH, Suh BK

Growth hormone (GH) is an essential element for normal growth. However, reports of normal growth without GH have been made in patients who have undergone brain surgery for craniopharyngioma. Normal...
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The Relationship between the Amisulpride-Induced Hyperprolactinemia and Taq1A Polymorphism of the Dopamine D2 Receptor Gene in Schizophrenia Patients

Kim JJ, Seo MJ, Choi TY, Lee JH

OBJECTIVES: This study was aimed to investigate the association between amisulpride-induced hyperprolactinemia and the Taq1A polymorphism in the D2 dopamine receptor gene (DRD2) in schizophrenic patients. METHODS: The plasma concentrations of...
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Escitalopram-Induced Amenorrhea and False Positive Urine Pregnancy Test

Selvaraj V, Hour S, Gunasekar , Gray C, Smith JF

Escitalopram is a selective serotonin reuptake inhibitor antidepressant approved by the Food and Drug Administration for the treatment of major depressive disorder and generalized anxiety disorder. A 34-year-old female patient...
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Effects of Antipsychotics on Bone Mineral Density in Patients with Schizophrenia: Gender Differences

Chen CY, Lane HY, Lin CH

Low bone mineral density (BMD) and osteoporosis are common in patients with schizophrenia and detrimental to illness prognosis and life quality. Although the pathogenesis is not fully clear, series of...
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Hypopituitarism Secondary to Paraclinoid Internal Carotid Artery Aneurysm

Lee SH, Song JW, Cho JY, Kim DS, Ryu YJ, Park SY, Ihm SH

Pituitary insufficiency due to a sellar aneurysm is relatively uncommon. The prevalence of this disorder was
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Acromegaly due to a Macroinvasive Plurihormonal Pituitary Adenoma and a Rectal Carcinoid Tumor

Chin SO, Hwang JK, Rhee SY, Chon S, Oh S, Lee M, Pellegata , Kim SW

A macroinvasive pituitary adenoma with plurihormonality usually causes acromegaly and hyperprolactinemia, and also accompanies with neurologic symptoms such as visual disturbances. However, its concurrent presentation with a rectal carcinoid tumor...
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Different Responses of Aripiprazole Combination Treatment in Antipsychotics-Induced Hyperprolactinemia: 2 Cases

Cho JW, Oh SM, Kim CE

Hyperprolactinemia is a well-known neuroendocrine side effect to antipsychotic agent. Combined treatment of aripiprazole is recognized as an effective solution against hyperprolactinemia caused by antipsychotic agent. We report 2 progressive...
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Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine

Chatterjee SS, Mitra S, Mallik N

While fluoxetine (FXT) is a frequently prescribed selective serotonin reuptake inhibitor (SSRI), with few major side-effects; altered serotonergic transmissions in hypothalamic pathways might lead to a distressing, and often embarrassing,...
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One-Year Follow-Up of Serum Prolactin Level in Schizophrenia Patients Treated with Blonanserin: A Case Series

Takahashi , Suzuki M, Uchiyama M

In our previous study, a prolactin elevation was more frequently in risperidone than in blonanserin; however, it was more often in blonanserin than in olanzapine. Therefore, while a rate of...
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The Short-Term Effects of Risperidone-Induced Hyperprolactinemia on Lipid Metabolism in Drug-Naive Children and Adolescents

Park EJ, Park YM

OBJECTIVE: The present cross-sectional study was designed to assess the risk of elevated prolactin levels and other hormonal or metabolic changes in children and adolescents taking risperidone. METHODS: Twenty-five children and...
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A Case of Pituitary Macroadenoma Concurrently Diagnosed in a Patient Undergoing Antipsychotic Treatment

Kim BS, Kim JS, Ryu HK, Park JW, Hyun SA, Kang JW, Choi YJ

Antipsychotics are the drug of choice for patients with schizophrenia, but they can induce hyperprolactinemia and growth of pituitary adenomas by blocking dopamine 2 receptors in the pituitary gland. In...
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Early Prediction of Long-Term Response to Cabergoline in Patients with Macroprolactinomas

Lee Y, Ku CR, Kim EH, Hong JW, Lee EJ, Kim SH

BACKGROUND: Cabergoline is typically effective for treating prolactinomas; however, some patients display cabergoline resistance, and the early characteristics of these patients remain unclear. We analyzed early indicators predicting long-term response...
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Using Growth Hormone Levels to Detect Macroadenoma in Patients with Acromegaly

Park JY, Kim JH, Kim SW, Chung JH, Min YK, Lee MS, Lee MK, Kim KW

BACKGROUND: The aim of this study was to assess the clinical differences between acromegalic patients with microadenoma and patients with macroadenoma, and to evaluate the predictive value of growth hormone...
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