J Korean Neuropsychiatr Assoc.  2018 Aug;57(3):230-234. 10.4306/jknpa.2018.57.3.230.

Treatment-Resistant Schizophrenia : Pathophysiology and Treatment

Affiliations
  • 1Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Korea. euitae.kim@snu.ac.kr
  • 2Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

A large proportion of patients with schizophrenia show a poor response to first-line antipsychotic drugs, which is termed treatment-resistant schizophrenia. Previous studies found that a different neurobiology might underlie treatment-resistant schizophrenia, which necessitates the development of different therapeutic approaches for treating treatment-resistant schizophrenia. This study reviewed previous studies on the pathophysiology of treatment-resistant schizophrenia and the pharmacological intervention, and forthcoming investigations of treatment-resistant schizophrenia are suggested.

Keyword

Treatment-resistant; Schizophrenia; Neurobiology; Strategy

MeSH Terms

Antipsychotic Agents
Humans
Neurobiology
Schizophrenia*
Antipsychotic Agents
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