J Korean Neuropsychiatr Assoc.  2018 Aug;57(3):230-234. 10.4306/jknpa.2018.57.3.230.

Treatment-Resistant Schizophrenia : Pathophysiology and Treatment

• Kim E

• KMID: 2429227
• DOI: http://doi.org/10.4306/jknpa.2018.57.3.230

Abstract

A large proportion of patients with schizophrenia show a poor response to first-line antipsychotic drugs, which is termed treatment-resistant schizophrenia. Previous studies found that a different neurobiology might underlie treatment-resistant schizophrenia, which necessitates the development of different therapeutic approaches for treating treatment-resistant schizophrenia. This study reviewed previous studies on the pathophysiology of treatment-resistant schizophrenia and the pharmacological intervention, and forthcoming investigations of treatment-resistant schizophrenia are suggested.

Keyword

Treatment-resistant; Schizophrenia; Neurobiology; Strategy

MeSH Terms

Antipsychotic Agents
Humans
Neurobiology
Schizophrenia*
Antipsychotic Agents

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