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Experimental Neurobiology: The Past, Present, and Future

Oh YJ, Han PL, Lee CJ

No abstract available.
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Neurobiological understanding of suicide

Kim S, Lee KU

Suicide is a complex phenomenon resulting from interactions between individual vulnerabilities and socio-environmental factors. The current review primarily focuses on research into the serotonin system, hypothalamic-pituitary-adrenal axis, neurotrophic factors, lipid...
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Treatment-Resistant Schizophrenia : Pathophysiology and Treatment

Kim E

A large proportion of patients with schizophrenia show a poor response to first-line antipsychotic drugs, which is termed treatment-resistant schizophrenia. Previous studies found that a different neurobiology might underlie treatment-resistant...
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Dissociative Experience in Unipolar and Bipolar Depression: Exploring the Great Divide

Chatterjee SS, Pal A, Mallik N, Ghosal M, Saha G

OBJECTIVE: Unipolar and bipolar depression (UD and BD) differ strikingly in respect to neurobiology, course and management, but their apparent clinical similarity often leads to misdiagnosis resulting in chronicity of...
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Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects

Choi JH, Jeong E, Youn BS, Kim MS

BACKGROUND: Blood levels of many hormones show rhythmic fluctuations with variable duration of cycles. Clusterin/apolipoprotein J is a glycoprotein which is highly expressed in the plasma and has modulatory roles...
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Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies

Tripathi A, Kar SK, Shukla R

Cognitive deficits are one of the core symptoms of schizophrenia that evolve during the course of schizophrenia, after being originated even before the onset of illness. Existing pharmacological and biological...
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A Pilot Examination of Oxidative Stress in Trichotillomania

Grant JE, Chamberlain SR

OBJECTIVE: Trichotillomania is a relatively common illness whose neurobiology is poorly understood. One treatment for adult trichotillomania, n-acetyl cysteine (NAC), has antioxidative properties, as well as effects on central glutamatergic...
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Secondary Short-Lasting Unilateral Neuralgiform Headache with Conjunctival Injection and Tearing: A New Case and a Literature Review

Cao Y, Yang F, Dong Z, Huang X, Cao B, Yu S

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) is a primary headache syndrome with an unclear pathogenesis. However, there is increasing evidence in the literature for secondary...
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How Electroconvulsive Therapy Works?: Understanding the Neurobiological Mechanisms

Singh A, Kar SK

Electroconvulsive therapy (ECT) is a time tested treatment modality for the management of various psychiatric disorders. There have been a lot of modifications in the techniques of delivering ECT over...
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Impact of Childhood Exposure to Intimate Partner Violence and Other Adversities

Franchek-Roa KM, Tiwari A, Lewis-O'Connor A, Campbell J

Childhood exposure to intimate partner violence (IPV) and other adversities has been shown to have adverse effects on health and well-being not only in childhood but also throughout the lifespan....
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Comparative study of fertilization rates of C57BL/6NKorl and C57BL/6N mice obtained from two other sources

Yun WB, Kim HR, Kim JE, Choi JY, Lee MR, Park JJ, Song BR, Jung YS, Song HK, Cho JY, Kim KS, Hwang DY

C57BL/6N is the most widely used inbred mouse strain applied in a wide variety of research areas including cancer, cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and...
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Development of a Diverse Learning Experience for Diverse Psychiatry Resident Needs: A Four-Year Biological Psychiatry Curriculum Incorporating Principles of Neurobiology, Psychopharmacology, and Evidence-Based Practice

Muzyk AJ, Gagliardi , Rakesh G, Jiroutek M, Radhakrishnan R, Pae CU, Masand PS, Szabo ST

OBJECTIVE: A clinically relevant approach to patient care grounded in neurobiological constructs and evidence based practice which emphasizes a relevant psychopharmacology is needed to optimally train psychiatry residents. METHODS: We implemented...
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Wnt and GSK3 Signaling Pathways in Bipolar Disorder: Clinical and Therapeutic Implications

Muneer A

The neurobiology of bipolar disorder, a chronic and systemic ailment is not completely understood. The bipolar phenotype manifests in myriad ways, and psychopharmacological agents like lithium have long term beneficial...
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Aggression and Neurotransmitters

Yu SY, Choi Y, Kim S, Jeong HS, Ma J, Kim YH, Moon S, Kang I, Jeong E, Suh CW, Shin KS, Kim JE

Aggression and aggressive behaviors, often explained as harmful social interaction with the intention of hurting or inflicting damage upon another, have been considered as an adaptive mechanism from the evolutionary...
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Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder

Baek JH, Kim HJ, Fava M, Mischoulon D, Papakostas GI, Nierenberg A, Heo JY, Jeon HJ

OBJECTIVE: Anxious depression has a distinct neurobiology, clinical course and treatment response from non-anxious depression. Role of inflammation in anxious depression has not been examined. As an exploratory study to...
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Mammalian Target of Rapamycin Signaling Pathways and Depression

Lee JG, Seo MK, Park SW, Kim YH

Depression is a complicated psychiatric illness with severe consequences. Despite recent advanced achievements of molecular neurobiology, pathophysiology of depression has not been well elucidated. Among new findings of pathophysiology of...
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A Short Review on the Current Understanding of Autism Spectrum Disorders

Park HR, Lee JM, Moon HE, Lee DS, Kim BN, Kim J, Kim DG, Paek SH

Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by a deficit in social behaviors and nonverbal interactions such as reduced eye contact, facial expression, and body gestures...
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Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers

Muneer A

Bipolar disorder is a severe and enduring psychiatric condition which in many cases starts during early adulthood and follows a relapsing and remitting course throughout life. In many patients the...
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What Difference Does Psychoanalysis Training Make in Psychiatric Clinical Practice?

Lee CH

Psychiatrists must learn and experience various fields of psychiatric medicine and sciences in order to be able to comprehensively understand the human mind and pathological mental phenomena. Without this all-encompassing...
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The Neurobiology of Bipolar Disorder: An Integrated Approach

Muneer A

Bipolar disorder is a heterogeneous condition with myriad clinical manifestations and many comorbidities leading to severe disabilities in the biopsychosocial realm. The objective of this review article was to underline...
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