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Clinical Correlates of QTc Prolongation in Patients with Schizophrenia : A Retrospective Study

Lee JS, Park J, Park S

Objectives:QTc prolongation due to antipsychotics is of major concern because it may lead to fatal ventricular arrhythmia such as torsade de pointes. However, few studies have been conducted on QTc...
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The Comparison of Prevalence and Patterns of Sexual Dysfunction between Patients with Schizophrenia and Healthy Controls

Yoon JH, Back DU, Jae YM, Jang SH, Lee KH, Choi JH

  • KMID: 2517219
  • J Korean Soc Biol Ther Psychiatry.
  • 2021 Jun;27(2):112-123.
Objectives:Sexual dysfunction is common in both untreated and treated patients with schizophrenia and known as affecting the quality of life and drug compliance. The primary objective of this study is...
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Clinical Benefit and Utility of Switching to Aripiprazole Once Monthly in Patients with Antipsychotic Polypharmacy or Long Acting Injectable Antipsychotics for Patients with Schizophrenia in Routine Practice: A Retrospective, Observation Study

Pae CU, Han C, Bahk WM, Lee SJ, Patkar AA, Masand PS

Objective: In a number of controlled clinical trials and naturalistic studies, aripiprazole once monthly (AOM) has been found to be effective and safe as acute and maintenance treatment options for...
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Current Status of Clozapine for Treatment-Resistant Schizophrenia

Kim SH

Clozapine is the first and most effective atypical antipsychotic drug for treatment-resistant schizophrenia (TRS). After withdrawal of clozapine due to concerns of agranulocytosis, clozapine was reintroduced with a comprehensive safety...
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Clozapine Is Better Tolerated in Younger Patients: Risk Factors for Discontinuation from a Nationwide Database in Japan

Toyoda K, Hata T, Yamauchi S, Kinoshita S, Nishihara M, Uchiyama K, Inada K, Kanazawa T

Objective The effectiveness of clozapine is clearly superior to other antipsychotics in the treatment of refractory schizophrenia. Clozapine leads to various side effects, and therefore many patients are forced to...
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Management of Weight Gain and Obesity Associated With Antipsychotics

Lee NH, Lee JC

Objectives:The risk of weight gain is high when using antipsychotic drugs, and the prevalence of obesity in people with mental illness is high. Obesity management in psychiatric patients is important...
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Neuroleptic malignant syndrome cases in a Moroccan intensive care unit: a retrospective analysis and literature review

Touzani S, Hamdouni M, Houari N, Khbiza YY, Elbouazzaoui A, Boukatta B, Kanjaa N

Background: Neuroleptic malignant syndrome (NMS) is a rare but potentially life-threatening neuropsychiatric emergency. The aim of our study was to update our bedside procedures by investigating NMS cases managed in...
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Atypical Antipsychotics Mediate Dynamics of Intrinsic Brain Activity in Early-Stage Schizophrenia? A Preliminary Study

Wang Y, Jiang Y, Liu D, Zhang J, Yao D, Luo C, Wang J

Objective Abnormalities of static brain activity have been reported in schizophrenia, but it remains to be clarified the temporal variability of intrinsic brain activities in schizophrenia and how atypical antipsychotics...
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Clinical Characteristics of Patients with Schizophrenia Maintained without Antipsychotics: A Cross-sectional Survey of a Case Series

Tani H, Tomita M, Suzuki T, Mimura M, Uchida H

Objective: While antipsychotics are necessary for relapse prevention in the treatment of schizophrenia in general, some minority of patients may be maintained without continuous antipsychotic treatment. However, the characteristics of...
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Exploring Hidden Issues in the Use of Antipsychotic Polypharmacy in the Treatment of Schizophrenia

Kim JJ, Pae CU, Han C, Bahk WM, Lee SJ, Patkar AA, Masand PS

The mainstay of schizophrenia treatment is pharmacological therapy using various antipsychotics including first- and second-generation antipsychotics which have different pharmacokinetic and pharmacodynamic property leading to differential presentation of adverse events...
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Suicidal Risk in Depressed Patients with the Treatment by Antipsychotics and Antidepressant Compared to Antidepressant Monotherapy: A Pilot Study Using Psychiatric Common Data Model

Ha JH, Lee E, Lee D, Cho YH, Lee H, Park B, Son SJ

Objectives This study examined the effects of reducing suicide attempts when taking antipsychotics in combination with antidepressants in depressive patients. Methods Using a common data model of electronic medical records at...
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One-year Outcome of First vs. Later Episode Schizophrenia: A Real-world Naturalistic Study

Fountoulakis KN, Panagiotidis P, Theofilidis AT, Nimatoudis I

Objective: The aim the study was to calculate remission, recovery and relapse rates in first episode patients with schizophrenia (FES) vs. patients at a later phase (non-FES). Methods: Thirty-two FES and...
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Incidence of Neutropenia with Valproate, Antipsychotics, and ADHD Medication Combination Treatment in Children and Adolescents

Oh Y, Joung YS, Choi J

This study's aim was to investigate whether the incidence of neutropenia was higher in subjects who received a combination pharmacotherapy with valproate (VPA), antipsychotics (APs), and attention deficit hyperactivity disorder...
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Efficacy and Safety of Antipsychotics for Delirium Treatment in Cancer Patients Receiving Palliative Care

Oh S, Geum MJ, Kim JS, Son ES, Yu YM

Background: Delirium is a neuropsychiatric disorder characterized by sudden impairments in consciousness, attention, and perception. The evidence of successful pharmacological interventions for delirium is limited, and medication recommendations for managing...
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The Prescribing Patterns of Antipsychotic Drugs and Antiparkinsonian Drugs in Elderly Patients with Dementia

Yoon SM, Lee S, Chang JE, Lee YS, Rhew K

Background: The number of patients with dementia continues to increase as the age of aging continues to grow. Psychiatric symptoms caused by senile dementia are controlled using antipsychotics. However, these...
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Open channel block of Kv1.4 potassium channels by aripiprazole

Park J, Cho KH, Lee HJ, Choi JS, Rhie DJ

Aripiprazole is a quinolinone derivative approved as an atypical antipsychotic drug for the treatment of schizophrenia and bipolar disorder. It acts as with partial agonist activities at the dopamine D2...
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Association between Thyroid Dysfunction and Severity, Treatment Response in Schizophrenic Inpatients

Jung MJ, Hwang HK, Seo YE, Choi JH

OBJECTIVES: Thyroid hormone deficiency during the neurodevelopmental period can impair brain development and induce psychiatric symptoms. This study examined the association between thyroid dysfunction and the severity of symptoms in...
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Prescribing Pattern of Clozapine and Clinical Factors associated with Discontinuation of Clozapine

Kang SH, Lee HW

OBJECTIVES: Clozapine is the drug of choice in treatment-resistant schizophrenia. However, its use is often delayed and a significant proportion of clozapine treated patients fails to respond and experience potentially...
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The Long-Acting Injectable Antipsychotics in Clinical Practice

Lee K

Symptomatic relapse is observed frequently and often associated with social and/or occupational decline that can be difficult to reverse in patients with schizophrenia. Several atypical antipsychotics, including risperidone, olanzapine, paliperidone,...
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Metabolic Side Effects of Antipsychotic Medication: An Overview

Lee J

Metabolic syndrome (MetS) is a collection of abnormal clinical and metabolic findings that are predictive of cardiovascular disease. The prevalence (approximately 30–40%) of MetS in patients with schizophrenia is higher...
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