Exp Mol Med.
2009 Dec;41(12):873-879. 10.3858/emm.2009.41.12.093.
Cross-talk between BubR1 expression and the commitment to differentiate in adipose-derived mesenchymal stem cells
- Affiliations
-
- 1Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea. cwlee@med.skku.ac.kr
- 2Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.
- 3Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Korea.
- KMID: 1099864
- DOI: http://doi.org/10.3858/emm.2009.41.12.093
Abstract
- BubR1 mitotic checkpoint kinase monitors attachment of microtubules to kinetochores and links regulation of the chromosome-spindle attachment to mitotic checkpoint signaling. Defects in BubR1-mediated signaling severely perturb checkpoint control and are linked to diseases such as cancer. Studies using BubR1 mouse models suggest that BubR1 activities prevent premature aging and infertility. In this study, we show that BubR1 depletion in human adipose-derived mesenchymal stem cells (ASCs) precedes loss of the differentiation potential and induction of replicative senescence. These effects occur independently of p16(INK4A) expression and may involve DNA methylation. Our results reveal a new and unsuspected feature of BubR1 expression in regulation of adult stem cell differentiation.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Adipose Tissue Derived Mesenchymal Stem Cells
- Adipose-derived stem cells: characterization and clinical application
- Concise Review: Differentiation of Human Adult Stem Cells Into Hepatocyte-like Cells In vitro
- Mesenchymal Stem Cell Therapy in Pulmonary Disease
- A study on the osteogenic differentiation of adipose-derived adult stem cell
