- Can we rejuvenate? Implications of biological aging research
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Son Y, Kim JR
- KMID: 2400323
- Yeungnam Univ J Med.
- 2017 Jun;34(1):1-10.
- doi: 10.12701/yujm.2017.34.1.1
The life history of man is summarized as a birth-aging-disease-death. Man eventually ages and dies. How long can humans live? What is aging? Why do we age? Is aging inevitable?... -
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- Versatile Functions of Caveolin-1 in Aging-related Diseases
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Nguyen KC, Cho KA
- KMID: 2367337
- Chonnam Med J.
- 2017 Jan;53(1):28-36.
- doi: 10.4068/cmj.2017.53.1.28
Caveolin-1 (Cav-1) is a trans-membrane protein that is a major component of the caveolae structure on the plasma membrane. Cav-1 is involved in the regulation of various cellular processes, including... -
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- Significance of Cellular Senescence in Aging and Cancer
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Grimes A, Chandra SB
- KMID: 1972671
- Cancer Res Treat.
- 2009 Dec;41(4):187-195.
Cellular senescence is a mechanism that induces an irreversible growth arrest in all somatic cells. Senescent cells are metabolically active but lack the capacity to replicate. Evolutionary theories suggest that... -
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- Molecular Mechanisms and In Vivo Mouse Models of Skin Aging Associated with Dermal Matrix Alterations
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Hwang KA, Yi BR, Choi KC
- KMID: 2391851
- Lab Anim Res.
- 2011 Mar;27(1):1-8.
- doi: 10.5625/lar.2011.27.1.1
Skin is the most superficial body organ and plays an important role in protecting the body from environmental damage and in forming social relations. With the increase of the aging... -
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- Mechanism of aging and prevention
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Kim JS
- KMID: 2054220
- Immune Netw.
- 2001 Aug;1(2):104-108.
- doi: 10.4110/in.2001.1.2.104
Aging is a senescence and defined as a normal physiologic and structural alterations in almost all organ systems with age. As Leonard Hayflick, one of the first gerontologist s to... -
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- How Does Obesity and Physical Activity Affect Aging?: Focused on Telomere as a Biomarker of Aging
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Shin YA
- KMID: 2459821
- J Obes Metab Syndr.
- 2019 Jun;28(2):92-104.
- doi: 10.7570/jomes.2019.28.2.92
Obesity is known to continuously increase systemic inflammation and oxidative stress, leading to shorter telomere length. However, research regarding the correlation between physical activity, exercise, obesity, and telomere length is... -
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- Cellular Senescence in Arterial Diseases
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Shimizu I, Minamino T
- KMID: 2470802
- J Lipid Atheroscler.
- 2020 Jan;9(1):79-91.
- doi: 10.12997/jla.2020.9.1.79
Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the... -
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- Age-related decline in expression of calnexin
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Choi BH, Kim JS
- KMID: 1123772
- Exp Mol Med.
- 2004 Oct;36(5):499-503.
Aging is accompanied by the changes in the cells that decrease their capacity to respond to various forms of stress. Cells are known to respond to stresses through expression of... -
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- Profiling of genes in healthy hGF, aging hGF, healthy hPDLF and inflammatory hPDLF by DNA microarray
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Yun SJ, Kim BO, Yun JH, Kang DW, Jang HS
- KMID: 2425004
- J Korean Acad Periodontol.
- 2006 Sep;36(3):767-782.
No abstract available. -
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- Caveolin-1 is involved in high glucose accelerated human glomerular mesangial cell senescence
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Feng X, Gao W, Li Y
- KMID: 2411491
- Korean J Intern Med.
- 2017 Sep;32(5):883-889.
- doi: 10.3904/kjim.2015.254
BACKGROUND/AIMS:: We demonstrated the role of caveolin-1 involved in high glucose (HG)-induced glomerular mesangial cells (GMCs) senescence. METHODS:: HG was used to stimulate GMCs. The telomere lengths were analyzed by Southern... -
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- Biliverdin reductase A in the prevention of cellular senescence against oxidative stress
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Kim SY, Kang HT, Choi HR, Park SC
- KMID: 991619
- Exp Mol Med.
- 2011 Jan;43(1):15-23.
- doi: 10.3858/emm.2011.43.1.002
Biliverdin reductase A (BLVRA), an enzyme that converts biliverdin to bilirubin, has recently emerged as a key regulator of the cellular redox cycle. However, the role of BLVRA in the... -
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- The Role of Cellular Senescence in the Gastrointestinal Mucosa
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Penfield J, Anderson M, Lutzke L, Wang KK
- KMID: 1431336
- Gut Liver.
- 2013 May;7(3):270-277.
- doi: 10.5009/gnl.2013.7.3.270
Cellular senescence is a biologically irreversible state of cell-growth arrest that occurs following either a replicative or an oncogenic stimulus. This phenomenon occurs as a response to the presence of... -
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- Characterization of Senescence of Culture-expanded Human Adipose-derived Mesenchymal Stem Cells
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Legzdina D, Romanauska A, Nikulshin , Kozlovska , Berzins U
- KMID: 2164169
- Int J Stem Cells.
- 2016 May;9(1):124-136.
- doi: 10.15283/ijsc.2016.9.1.124
BACKGROUND AND OBJECTIVES: Adipose-derived mesenchymal stem cells (ADSCs) are promising candidates in regenerative medicine. The need for in vitro propagation to obtain therapeutic quantities of the cells imposes a risk... -
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- Autophagy, Cellular Aging and Age-related Human Diseases
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Cheon SY, Kim H, Rubinsztein DC, Lee JE
- KMID: 2468882
- Exp Neurobiol.
- 2019 Dec;28(6):643-657.
- doi: 10.5607/en.2019.28.6.643
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of... -
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- An Effect of Testesterone on the Proliferation of Artificially Induced Senescent PC12 Pheochromocytoma Cells
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Lee E, Oh CS, Shin DH, Lee YS
- KMID: 2338398
- J Korean Geriatr Soc.
- 2005 Dec;9(4):301-305.
BACKGROUNDS: Although the role of testosterone in the neuroprotection is still poorly known, accumulating evidence suggests that testosterone may be an important role in neurodegenerative disease including dementia. So we... -
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- Survive or thrive: tradeoff strategy for cellular senescence
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Park SC
- KMID: 2386962
- Exp Mol Med.
- 2017 Jun;49(6):e342.
- doi: 10.1038/emm.2017.94
Aging-dependent cellular behaviors toward extrinsic stress are characterized by the confined localization of certain molecules to either nuclear or perinuclear regions. Although most growth factors can activate downstream signaling in... -
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- Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes
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Bang M, Ryu O, Kim DG, Mabunga DF, Cho KS, Kim Y, Han SH, Kwon KJ, Shin CY
- KMID: 2447855
- Biomol Ther.
- 2019 May;27(3):283-289.
- doi: 10.4062/biomolther.2018.107
Brain aging induces neuropsychological changes, such as decreased memory capacity, language ability, and attention; and is also associated with neurodegenerative diseases. However, most of the studies on brain aging are... -
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- Cross-talk between BubR1 expression and the commitment to differentiate in adipose-derived mesenchymal stem cells
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Lee J, Lee CG, Lee KW, Lee CW
- KMID: 1099864
- Exp Mol Med.
- 2009 Dec;41(12):873-879.
- doi: 10.3858/emm.2009.41.12.093
BubR1 mitotic checkpoint kinase monitors attachment of microtubules to kinetochores and links regulation of the chromosome-spindle attachment to mitotic checkpoint signaling. Defects in BubR1-mediated signaling severely perturb checkpoint control and... -
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- Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
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Kim SG, Sung JY, Kim JR, Choi HC
- KMID: 2466571
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):69-79.
- doi: 10.4196/kjpp.2020.24.1.69
Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance... -
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- The dependence of nitric oxide synthase inhibition caused by cigarette smoking extract on the cellular aging of bovine aortic endothelial cells
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Le V, Kim YH, Min J
- KMID: 2380103
- Environ Health Toxicol.
- 2014 ;29(1):e2014010.
- doi: 10.5620/eht.e2014010
OBJECTIVES: Cigarette smoking had been recorded as the main cause of impaired endothelium- dependent vasodilation in smokers by reducing nitric oxide (NO), a production of endothelial nitric oxide synthase (eNOS).... -
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