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Cellular Senescence in Arterial Diseases

Shimizu I, Minamino T

Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the...
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Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway

Kim SG, Sung JY, Kim JR, Choi HC

Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance...
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Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature

Muneer A, Minhas FA

Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric...
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A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-Line Chemotherapy in Metastatic Colorectal Cancer Patients

Kim Y, Kim TW, Han SW, Ahn JB, Kim ST, Lee J, Park JO, Park YS, Lim HY, Kang WK

PURPOSE: Simvastatin has demonstrated anti-tumor activity in preclinical studies via tumor cell senescence, apoptosis, and anti-angiogenesis. This phase II trial evaluated the efficacy and toxicity profile of conventional XELOX and...
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Initiation of human parturition: signaling from senescent fetal tissues via extracellular vesicle mediated paracrine mechanism

Menon R

A better understanding of the underlying mechanisms by which signals from the fetus initiate human parturition is required. Our recent findings support the core hypothesis that oxidative stress (OS) and...
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Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway

Kim I, Park CS, Lee HY

BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown. METHODS: We cultured human coronary artery smooth muscle cells (hCSMCs) and...
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How Does Obesity and Physical Activity Affect Aging?: Focused on Telomere as a Biomarker of Aging

Shin YA

Obesity is known to continuously increase systemic inflammation and oxidative stress, leading to shorter telomere length. However, research regarding the correlation between physical activity, exercise, obesity, and telomere length is...
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Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes

Bang M, Ryu O, Kim DG, Mabunga DF, Cho KS, Kim Y, Han SH, Kwon KJ, Shin CY

Brain aging induces neuropsychological changes, such as decreased memory capacity, language ability, and attention; and is also associated with neurodegenerative diseases. However, most of the studies on brain aging are...
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Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer

Wang Z, Gao J, Zhou J, Liu H, Xu C

OBJECTIVE: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP...
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Effects of TGF-β1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells

Salkın H, Gönen ZB, Ergen E, Bahar D, Çetin M

OBJECTIVE: The aim of our study was to investigate the effect of Transforming growth factor beta-1 (TGF-β1) gene therapy on the surface markers, multilineage differentiation, viability, apoptosis, cell cycle, DNA...
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Autophagy, Cellular Aging and Age-related Human Diseases

Cheon SY, Kim H, Rubinsztein DC, Lee JE

Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of...
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Methyl-CpG Binding Protein 2 in Alzheimer Dementia

Kim B, Choi Y, Kim HS, Im HI

Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp. Methyl-CpG Binding Protein 2 (MeCP2)...
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Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes

Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY

Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and...
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Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus

Lee TK, Park YE, Park CW, Kim B, Lee JC, Park JH, Lee HA, Won MH, Ahn JH

P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult...
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Effect of Chronic Benzalkonium Chloride Exposure on Senescence in Trabecular Meshwork Cells

Park J, Lee SJ, Lee KW, Kim JC

PURPOSE: To determine the possible effects of chronic exposure of low dose benzalkonium chloride (BAK) on trabecular meshwork cells, and to characterize the pathways involved in the effects. METHODS: Trabecular meshwork...
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Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy

Yun SP, Han YS, Lee JH, Kim SM, Lee SH

p-Cresol, found at high concentrations in the serum of chronic kidney failure patients, is known to cause cell senescence and other complications in different parts of the body. p-Cresol is...
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Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis

Kim SY, Kim TI

In the past two decades, besides conventional adenoma pathway, a subset of colonic lesions, including hyperplastic polyps, sessile serrated adenoma/polyps, and traditional serrated adenomas have been suggested as precancerous lesions...
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Enhancement of Replication and Differentiation Potential of Human Bone Marrow Stem Cells by Nicotinamide Treatment

Ok JS, Song SB, Hwang ES

BACKGROUND AND OBJECTIVES: Therapies using mesenchymal stem cells (MSCs) generally require substantial expansion of cell populations. However, the replicative life span of MSCs is limited and their multipotency declines over...
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Caveolin-1 is involved in high glucose accelerated human glomerular mesangial cell senescence

Feng X, Gao W, Li Y

BACKGROUND/AIMS:: We demonstrated the role of caveolin-1 involved in high glucose (HG)-induced glomerular mesangial cells (GMCs) senescence. METHODS:: HG was used to stimulate GMCs. The telomere lengths were analyzed by Southern...
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Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis

Lim CJ, Lee YM, Kang SG, Lim HW, Shin KO, Jeong SK, Huh YH, Choi S, Kor M, Seo HS, Park BD, Park K, Ahn JK, Uchida Y, Park K

Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only...
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