- Cellular Senescence in Arterial Diseases
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Shimizu I, Minamino T
- KMID: 2470802
- J Lipid Atheroscler.
- 2020 Jan;9(1):79-91.
- doi: 10.12997/jla.2020.9.1.79
Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the... -
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- Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
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Kim SG, Sung JY, Kim JR, Choi HC
- KMID: 2466571
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):69-79.
- doi: 10.4196/kjpp.2020.24.1.69
Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance... -
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- Autophagy, Cellular Aging and Age-related Human Diseases
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Cheon SY, Kim H, Rubinsztein DC, Lee JE
- KMID: 2468882
- Exp Neurobiol.
- 2019 Dec;28(6):643-657.
- doi: 10.5607/en.2019.28.6.643
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of... -
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- Methyl-CpG Binding Protein 2 in Alzheimer Dementia
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Kim B, Choi Y, Kim HS, Im HI
- KMID: 2467315
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S72-S81.
- doi: 10.5213/inj.1938196.098
Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp. Methyl-CpG Binding Protein 2 (MeCP2)... -
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- Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes
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Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY
- KMID: 2462880
- Biomol Ther.
- 2019 Nov;27(6):530-539.
- doi: 10.4062/biomolther.2019.151
Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and... -
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- Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus
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Lee TK, Park YE, Park CW, Kim B, Lee JC, Park JH, Lee HA, Won MH, Ahn JH
- KMID: 2470010
- Lab Anim Res.
- 2019 Oct;35(3):140-147.
- doi: 10.1186/s42826-019-0022-0
P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult... -
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- Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature
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Muneer A, Minhas FA
- KMID: 2457398
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):343-363.
- doi: 10.9758/cpn.2019.17.3.343
Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric... -
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- A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-Line Chemotherapy in Metastatic Colorectal Cancer Patients
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Kim Y, Kim TW, Han SW, Ahn JB, Kim ST, Lee J, Park JO, Park YS, Lim HY, Kang WK
- KMID: 2454304
- Cancer Res Treat.
- 2019 Jul;51(3):1128-1134.
- doi: 10.4143/crt.2018.379
PURPOSE: Simvastatin has demonstrated anti-tumor activity in preclinical studies via tumor cell senescence, apoptosis, and anti-angiogenesis. This phase II trial evaluated the efficacy and toxicity profile of conventional XELOX and... -
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- Initiation of human parturition: signaling from senescent fetal tissues via extracellular vesicle mediated paracrine mechanism
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Menon R
- KMID: 2451649
- Obstet Gynecol Sci.
- 2019 Jul;62(4):199-211.
- doi: 10.5468/ogs.2019.62.4.199
A better understanding of the underlying mechanisms by which signals from the fetus initiate human parturition is required. Our recent findings support the core hypothesis that oxidative stress (OS) and... -
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- Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway
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Kim I, Park CS, Lee HY
- KMID: 2450393
- Korean Circ J.
- 2019 Jul;49(7):615-626.
- doi: 10.4070/kcj.2018.0379
BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown. METHODS: We cultured human coronary artery smooth muscle cells (hCSMCs) and... -
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- How Does Obesity and Physical Activity Affect Aging?: Focused on Telomere as a Biomarker of Aging
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Shin YA
- KMID: 2459821
- J Obes Metab Syndr.
- 2019 Jun;28(2):92-104.
- doi: 10.7570/jomes.2019.28.2.92
Obesity is known to continuously increase systemic inflammation and oxidative stress, leading to shorter telomere length. However, research regarding the correlation between physical activity, exercise, obesity, and telomere length is... -
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- Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes
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Bang M, Ryu O, Kim DG, Mabunga DF, Cho KS, Kim Y, Han SH, Kwon KJ, Shin CY
- KMID: 2447855
- Biomol Ther.
- 2019 May;27(3):283-289.
- doi: 10.4062/biomolther.2018.107
Brain aging induces neuropsychological changes, such as decreased memory capacity, language ability, and attention; and is also associated with neurodegenerative diseases. However, most of the studies on brain aging are... -
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- Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer
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Wang Z, Gao J, Zhou J, Liu H, Xu C
- KMID: 2457138
- J Gynecol Oncol.
- 2019 Mar;30(2):e26.
- doi: 10.3802/jgo.2019.30.e26
OBJECTIVE: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP... -
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- Effects of TGF-β1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells
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Salkın H, Gönen ZB, Ergen E, Bahar D, Çetin M
- KMID: 2447235
- Int J Stem Cells.
- 2019 Mar;12(1):170-182.
- doi: 10.15283/ijsc18051
OBJECTIVE: The aim of our study was to investigate the effect of Transforming growth factor beta-1 (TGF-β1) gene therapy on the surface markers, multilineage differentiation, viability, apoptosis, cell cycle, DNA... -
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- Effect of Chronic Benzalkonium Chloride Exposure on Senescence in Trabecular Meshwork Cells
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Park J, Lee SJ, Lee KW, Kim JC
- KMID: 2431840
- J Korean Ophthalmol Soc.
- 2019 Jan;60(1):55-61.
- doi: 10.3341/jkos.2019.60.1.55
PURPOSE: To determine the possible effects of chronic exposure of low dose benzalkonium chloride (BAK) on trabecular meshwork cells, and to characterize the pathways involved in the effects. METHODS: Trabecular meshwork... -
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- Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy
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Yun SP, Han YS, Lee JH, Kim SM, Lee SH
- KMID: 2420390
- Biomol Ther.
- 2018 Jul;26(4):389-398.
- doi: 10.4062/biomolther.2017.071
p-Cresol, found at high concentrations in the serum of chronic kidney failure patients, is known to cause cell senescence and other complications in different parts of the body. p-Cresol is... -
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- Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis
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Kim SY, Kim TI
- KMID: 2417647
- Intest Res.
- 2018 Jul;16(3):358-365.
- doi: 10.5217/ir.2018.16.3.358
In the past two decades, besides conventional adenoma pathway, a subset of colonic lesions, including hyperplastic polyps, sessile serrated adenoma/polyps, and traditional serrated adenomas have been suggested as precancerous lesions... -
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- Enhancement of Replication and Differentiation Potential of Human Bone Marrow Stem Cells by Nicotinamide Treatment
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Ok JS, Song SB, Hwang ES
- KMID: 2413497
- Int J Stem Cells.
- 2018 Jun;11(1):13-25.
- doi: 10.15283/ijsc18033
BACKGROUND AND OBJECTIVES: Therapies using mesenchymal stem cells (MSCs) generally require substantial expansion of cell populations. However, the replicative life span of MSCs is limited and their multipotency declines over... -
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- Differential and correlated expressions of p16/p21/p27/p38 in mammary gland tumors of aged dogs
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Kim HW, Ju JH, Shin JI, Seung BJ, Sur JH
- KMID: 2398507
- J Vet Sci.
- 2017 Dec;18(4):479-485.
- doi: 10.4142/jvs.2017.18.4.479
The inhibitory effect of neutering on mammary gland tumor development in dogs has been well described. However, we observed that the effect of neutering on tumor malignancy may be altered... -
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- Caveolin-1 is involved in high glucose accelerated human glomerular mesangial cell senescence
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Feng X, Gao W, Li Y
- KMID: 2411491
- Korean J Intern Med.
- 2017 Sep;32(5):883-889.
- doi: 10.3904/kjim.2015.254
BACKGROUND/AIMS:: We demonstrated the role of caveolin-1 involved in high glucose (HG)-induced glomerular mesangial cells (GMCs) senescence. METHODS:: HG was used to stimulate GMCs. The telomere lengths were analyzed by Southern... -
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