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Extensive characterization of feline intra-abdominal adipose-derived mesenchymal stem cells

Kim HR, Lee J, Byeon JS, Gu NY, Lee J, Cho IS, Cha SH

Mesenchymal stem cells (MSCs) isolated from various tissues have been well characterized for therapeutic application to clinical diseases. However, in contrast to MSCs from other animal species, the characteristics of...
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Effect of donor age on the proliferation and multipotency of canine adipose-derived mesenchymal stem cells

Lee J, Lee KS, Kim CL, Byeon JS, Gu NY, Cho IS, Cha SH

Research into adipose tissue-derived mesenchymal stem cells (AD-MSCs) has demonstrated the feasibility of their use in clinical applications due to their ease of isolation and abundance in adipose tissue. We...
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Adipose-Derived Regenerative Cell Injection Therapy for Postprostatectomy Incontinence: A Phase I Clinical Study

Choi JY, Kim TH, Yang JD, Suh JS, Kwon TG

PURPOSE: We report our initial experience with transurethral injection of autologous adipose-derived regenerative cells (ADRCs) for the treatment of urinary incontinence after radical prostatectomy. MATERIALS AND METHODS: After providing written informed...
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MicroRNA-103a-3p controls proliferation and osteogenic differentiation of human adipose tissue-derived stromal cells

Kim DS, Lee SY, Lee JH, Bae YC, Jung JS

The elucidation of the molecular mechanisms underlying the differentiation and proliferation of human adipose tissue-derived stromal cells (hADSCs) represents a critical step in the development of hADSCs-based cellular therapies. To...
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Clinical Application of Adipose Stem Cells in Plastic Surgery

Kim YJ, Jeong JH

Adipose stem cells (ASCs) are a type of adult stem cells that share common characteristics with typical mesenchymal stem cells. In the last decade, ASCs have been shown to be...
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Regulation of osteogenic differentiation of human adipose-derived stem cells by controlling electromagnetic field conditions

Kang KS, Hong JM, Kang JA, Rhie JW, Jeong YH, Cho DW

  • KMID: 2154225
  • Exp Mol Med.
  • 2013 Jan;45(1):e6.
Many studies have reported that an electromagnetic field can promote osteogenic differentiation of mesenchymal stem cells. However, experimental results have differed depending on the experimental and environmental conditions. Optimization of...
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Rapid Isolation of Adipose Tissue-Derived Stem Cells by the Storage of Lipoaspirates

Eom YW, Lee JE, Yang MS, Jang IK, Kim HE, Lee DH, Kim YJ, Park WJ, Kong JH, Shim KY, Lee JI, Kim HS

PURPOSE: This study examined a rapid isolation method decreasing the time and cost of the clinical application of adipose tissue-derived stem cells (ASCs). MATERIALS AND METHODS: Aliquots (10 g) of the...
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In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors

Baek SJ, Kang SK, Ra JC

The homing properties of adipose tissue-derived mesenchymal stem cells (AdMSCs) have stimulated intravenous applications for their use in stem cell therapy. However, the soluble factors and corresponding cellular receptors responsible...
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Establishment of Efficacy and Safety Assessment of Human Adipose Tissue-Derived Mesenchymal Stem Cells (hATMSCs) in a Nude Rat Femoral Segmental Defect Model

Choi HJ, Kim JM, Kwon E, Che JH, Lee JI, Cho SR, Kang SK, Ra JC, Kang BC

Human adipose tissue-derived mesenchymal stem cell (hATMSC) have emerged as a potentially powerful tool for bone repair, but an appropriate evaluation system has not been established. The purpose of this...
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Synovial fluid of patients with rheumatoid arthritis induces alpha-smooth muscle actin in human adipose tissue-derived mesenchymal stem cells through a TGF-beta1-dependent mechanism

Song HY, Kim MY, Kim KH, Lee IH, Shin SH, Lee JS, Kim JH

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. Transforming growth factor-beta1 (TGF-beta1) is a secreted protein that promotes differentiation of...
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Therapeutic Potential of Human Adipose Stem Cells in a Rat Myocardial Infarction Model

Hwangbo S, Kim J, Her S, Cho H, Lee J

PURPOSE: Stem cell transplantation is expected to have good effects in the treatment of myocardial infarction (MI). We tested the effect of the transplantation of human adipose-derived cells (ASCs) in...
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Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury

Ryu HH, Lim JH, Byeon YE, Park JR, Seo MS, Lee YW, Kim WH, Kang KS, Kweon OK

In this study, we evaluated if the implantation of allogenic adipose-derived stem cells (ASCs) improved neurological function in a canine spinal cord injury model. Eleven adult dogs were assigned to...
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Cross-talk between BubR1 expression and the commitment to differentiate in adipose-derived mesenchymal stem cells

Lee J, Lee CG, Lee KW, Lee CW

BubR1 mitotic checkpoint kinase monitors attachment of microtubules to kinetochores and links regulation of the chromosome-spindle attachment to mitotic checkpoint signaling. Defects in BubR1-mediated signaling severely perturb checkpoint control and...
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Thromboxane A2 modulates migration, proliferation, and differentiation of adipose tissue-derived mesenchymal stem cells

Yun DH, Song HY, Lee MJ, Kim MR, Kim MY, Lee JS, Kim JH

Prostanoid metabolites are key mediators in inflammatory responses, and accumulating evidence suggests that mesenchymal stem cells (MSCs) can be recruited to injured or inflamed tissues. In the present study, we...
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Atrophy of brown adipocytes in the adult mouse causes transformation into white adipocyte-like cells

Kim DW, Kim BS, Kwon HS, Kim CG, Lee HW, Choi WH, Kim CG

  • KMID: 1119333
  • Exp Mol Med.
  • 2003 Dec;35(6):518-526.
Adipose tissue is an important endocrine regulator of glucose metabolism and energy homeostasis. Researches have focused on this tissue not only as a target for pharmacotherapy of obesity and insulin...
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