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Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells

Cho HS, Park SY, Kim SM, Kim WJ, Jung JY

BACKGROUND: Autophagy plays important roles in odontogenic differentiation of dental pulp cells (DPCs) in the developmental stage of tooth bud. Few studies have reported the role of autophagy during reparative...
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Interstitial Cells of Cajal and Neural Structures in the Human Fetal Appendix

Radenkovic G, Petrovic V, Zivanovic D, Stoiljkovic N, Sokolovic D, Zivkovic N, Radenkovic D, Velickov A, Jovanovic J

  • KMID: 2510070
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):127-133.
  • doi: 10.5056/jnm20100
Background/Aims The interstitial cells of Cajal (ICC) are located within and around the digestive tract’s muscle layers. They function as intestinal muscle pacemakers and aid in the modification of enteric neurotransmission....
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Peripheral Blood As a Source of Stem Cells for RegenerativeMedicine: Emphasis Towards Corneal EpithelialReconstruction—An In Vitro Study

Venugopal B, Mohan S, Kumary TV, Kumar PRA

BACKGROUND: Mesenchymal stem cell-based treatments are now emerging as a therapy for corneal epithelial damage.Although bone marrow, adipose tissue and umbilical cord blood are the main sources of mesenchymal stem...
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Metastasis of Poorly Differentiated Thyroid Carcinoma to the Sternum: A Case Report

Kim HJ, Youn I

Sternal metastasis of poorly differentiated thyroid carcinoma (PDTC) is rare, and only a few cases have been reported in the literature. Here, we report a case of sternal metastasis of...
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Cellular Response of Ventricular-Subventricular Neural Progenitor/Stem Cells to Neonatal Hypoxic-Ischemic Brain Injury and Their Enhanced Neurogenesis

Shin JE, Lee H, Jung K, Kim M, Hwang K, Han J, Lim J, Kim IS, Lim KI, Park KI

Purpose: To elucidate the brain’s intrinsic response to injury, we tracked the response of neural stem/progenitor cells (NSPCs) located in ventricular-subventricular zone (V-SVZ) to hypoxic-ischemic brain injury (HI). We also...
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Inhibitory effect of Chaenomelis Fructus ethanol extract on receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis

Park GH, Gu DR, Lee SH

The fruit of Chaenomeles sinensis (Thouin) Koehne (Chaenomelis Fructus) known as “Mo-Gua” in Korea has been commonly used in traditional medicine to treat inflammatory diseases, such as sore throat. However,...
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Molecular Characterization of Embryonic Stem Cell-Derived Cardiac Neural Crest-Like Cells Revealed a Spatiotemporal Expression of an Mlc-3 Isoform

Schmitteckert S, Ziegler C, Rappold GA, Niesler B, Rolletschek A

Background and Objectives: Pluripotent embryonic stem (ES) cells represent a perfect model system for the investigation of early developmental processes. Besides their differentiation into derivatives of the three primary germ...
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Coordination of Multiple Cellular Processes by NR5A1/Nr5a1

Morohashi Ki, Inoue M, Baba T

The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In relation to...
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Angiotensin II and TGF-β1 Induce Alterations in Human Amniotic Fluid-Derived Mesenchymal Stem Cells Leading to Cardiomyogenic Differentiation Initiation

Gasiūnienė M, Petkus G, Matuzevičius D, Navakauskas D, Navakauskienė R

BACKGROUND AND OBJECTIVES: Human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) may be a valuable source for cardiovascular tissue engineering and cell therapy. The aim of this study is to verify...
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Role of DNA Methylation in the Development and Differentiation of Intestinal Epithelial Cells and Smooth Muscle Cells

Jorgensen , Ro S

  • KMID: 2454636
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):377-386.
  • doi: 10.5056/jnm19077
The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has...
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Galectin-4 Interaction with CD14 Triggers the Differentiation of Monocytes into Macrophage-like Cells via the MAPK Signaling Pathway

Hong SH, Shin JS, Chung H, Park CG

Galectin-4 (Gal-4) is a β-galactoside-binding protein mostly expressed in the gastrointestinal tract of animals. Although intensive functional studies have been done for other galectin isoforms, the immunoregulatory function of Gal-4...
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Autophagy Mediates Astrogenesis in Adult Hippocampal Neural Stem Cells

Ha S, Jeong SH, Yi K, Chu JJ, Kim S, Kim EK, Yu SW

Neural stem cells (NSCs) have the ability to self-renew and differentiate into neurons, oligodendrocytes, and astrocytes. Highly dynamic nature of NSC differentiation requires the intimate involvement of catabolic processes such...
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Stem cell therapy in pain medicine

Han YH, Kim KH, Abdi S, Kim TK

Stem cells are attracting attention as a key element in future medicine, satisfying the desire to live a healthier life with the possibility that they can regenerate tissue damaged or...
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Effects of three-dimensionally printed polycaprolactone/β-tricalcium phosphate scaffold on osteogenic differentiation of adipose tissue- and bone marrow-derived stem cells

Park H, Kim JS, Oh EJ, Kim TJ, Kim HM, Shim JH, Yoon WS, Huh JB, Moon SH, Kang SS, Chung HY

BACKGROUND: Autogenous bone grafts have several limitations including donor-site problems and insufficient bone volume. To address these limitations, research on bone regeneration is being conducted actively. In this study, we...
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Possible Role of Single Stranded DNA Binding Protein 3 on Skin Hydration by Regulating Epidermal Differentiation

Choi MR, Shin JM, Shin YA, Chang YH, Chang MY, Lim CA, Sohn KC, Seo YJ, Kim CD, Lee JH, Lee Y

BACKGROUND: Skin hydration is a common problem both in elderly and young people as dry skin may cause irritation, dermatological disorders, and wrinkles. While both genetic and environmental factors seem...
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The Effect of Adiponectin on the Regulation of Filaggrin Expression in Normal Human Epidermal Keratinocytes

Choi SY, Kim MJ, Ahn GR, Park KY, Lee MK, Seo SJ

BACKGROUND: Adiponectin, an adipokine secreted from adipocytes, affects energy metabolism and also shows anti-diabetic and anti-inflammatory properties. Recent studies have reported that adiponectin plays a role in regulating skin inflammation. OBJECTIVE:...
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Aryl Hydrocarbon Receptor Ligands Indoxyl 3-sulfate and Indole-3-carbinol Inhibit FMS-like Tyrosine Kinase 3 Ligand-induced Bone Marrow-derived plasmacytoid Dendritic Cell Differentiation

Hwang WB, Kim DJ, Oh GS, Park JH

Aryl hydrocarbon receptor (AhR) regulates both innate and adaptive immune responses by sensing a variety of small synthetic and natural chemicals, which act as its ligands. AhR, which is expressed...
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Cellular Response of Anodized Titanium Surface by Poly(Lactide-co-Glycolide)/Bone Morphogenic Protein-2

Lee SY, Koak JY, Kim SK, Heo SJ

BACKGROUND: The purpose of this study is to examine physical characteristics of and initial biological properties to anodized titanium treated with poly(D,L-lactide-co-glycolide) (PLG) mixed with recombinant human bone morphogenic protein-2...
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Effects of radiofrequency exposure emitted from a GSM mobile phone on proliferation, differentiation, and apoptosis of neural stem cells

Eghlidospour M, Ghanbari A, Mortazavi , Azari H

Due to the importance of neural stem cells (NSCs) in plasticity of the nervous system and treating neurodegenerative diseases, the main goal of this study was to evaluate the effects...
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Melanin extract from Gallus gallus domesticus promotes proliferation and differentiation of osteoblastic MG-63 cells via bone morphogenetic protein-2 signaling

Yoo HS, Chung KH, Lee KJ, Kim DH, An JH

BACKGROUND/OBJECTIVES: Gallus gallus domesticus (GD) is a natural mutant breed of chicken in Korea with an atypical characterization of melanin in its tissue. This study investigated the effects of melanin...
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