Int J Stem Cells.  2014 Nov;7(2):49-54. 10.15283/ijsc.2014.7.2.49.

Concise Review: Differentiation of Human Adult Stem Cells Into Hepatocyte-like Cells In vitro

  • 1Department of Gastroenterology, Institute of Geriatrics, China.
  • 2Transfusion Blood Department, Chinese PLA General Hospital, Beijing, China.


Adult stem cells (ASCs) are undifferentiated cells found throughout the body that divide to replenish dying cells and regenerate damaged tissues, which are the powerful sources for cell therapy and tissue engineering. Bone marrow-derived mesenchymal stem cells (BMSCs), adipose tissue-derived mesenchymal stem cells (ADSCs), and peripheral blood monocytes (PBMCs) are the common ASCs, and many studies indicated that ASCs isolated from various adult tissues could be induced to hepatocyte-like cells in vitro. However, the isolation, culture protocols, characterization of ASCs and hepatocyte-like cells are different. This review aims to describe the isolation and culture procedures for ASCs, to summarize the molecular characterization of ASCs, to characterize function of hepatocyte-like cells, and to discuss the future role of ASCs in cell therapy and tissue engineering.


Adult stem cells; Bone marrow-derived mesenchymal stem cells; Adipose tissue-derived mesenchymal stem cells Peripheral blood monocytes; Hepatocyte-like cells

MeSH Terms

Adult Stem Cells*
Cell- and Tissue-Based Therapy
Mesenchymal Stromal Cells
Tissue Engineering
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