- DNA Methylation in Development
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Choe J
- KMID: 2184453
- J Genet Med.
- 2008 Dec;5(2):100-104.
DNA methylation is one of many epigenetic mechanisms that regulate gene expression in the human body. From the view of epigenetics, there are two phases of development, one for germ... -
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- DNA methylation: a cause and consequence of type 2 diabetes
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Kim M
- KMID: 2468864
- Genomics Inform.
- 2019 Dec;17(4):e38.
- doi: 10.5808/GI.2019.17.4.e38
DNA methylation is a relatively stable epigenetic modification that can regulate and stabilize gene expression patterns and hence establish cell identity. Because metabolic intermediates are key factors of DNA methylation... -
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- A Visualization Tool for Computational Analysis of DNA Methylation Level Using Bisulfite Sequencing Data
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Tae H
- KMID: 1806240
- Genomics Inform.
- 2011 Sep;9(3):136-137.
Methylation of cytosine is a post-synthesis modification that does not affect the primary DNA sequence but greatly influences gene expression level and phenotypes of an organism. As high-throughput sequencing of... -
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- DNA Methylation in Brain and Liver Tissues of Mice Infected with Scrapie Agent
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Choi EK, Uyeno S, Ono T, Carp RI, Kim YS
- KMID: 1551980
- J Korean Soc Virol.
- 1998 Jun;28(2):183-192.
DNA methylation degree in the several murine brain and liver genes of different ages and after scrapie infection have been examined by using methylation-sensitive restriction endonuclease digestion. We found that... -
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- Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers
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Kondo Y
- KMID: 1758603
- Yonsei Med J.
- 2009 Aug;50(4):455-463.
- doi: 10.3349/ymj.2009.50.4.455
DNA methylation, histone modifications, and the chromatin structure are profoundly altered in human cancers. The silencing of cancer-related genes by these epigenetic regulators is recognized as a key mechanism in... -
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- DNA methylation: an epigenetic mark of cellular memory
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Kim M, Costello J
- KMID: 2382713
- Exp Mol Med.
- 2017 Apr;49(4):e322.
- doi: 10.1038/emm.2017.10
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell divisions. During development and cell differentiation, DNA methylation is dynamic, but some DNA methylation patterns may... -
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- DNA Methylation in Lung Cancer
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Lee MK
- KMID: 2200226
- J Lung Cancer.
- 2002 Dec;1(1):23-28.
DNA modification in vertebrate genomes is confined to the self-complementary sequence CpG. Between 60% and 90% of CpGs are methylated at the 5 position of cytosine, and the remainder is... -
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- Disappearance of Serum Methylated p16 Indicates Longer Survival in Patients with Gastric Cancer
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Lim HK, Park JM, Chi KC, Lee EJ, Jeong EM
- KMID: 2372464
- J Gastric Cancer.
- 2013 Sep;13(3):157-163.
PURPOSE: The aim of this study was to assess clinical correlations with postoperative alteration of p16 DNA methylation, and to clarify whether postoperative changes in the serum DNA methylation status... -
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- Role of DNA Methylation in the Development and Differentiation of Intestinal Epithelial Cells and Smooth Muscle Cells
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Jorgensen , Ro S
- KMID: 2454636
- J Neurogastroenterol Motil.
- 2019 Jul;25(3):377-386.
- doi: 10.5056/jnm19077
The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has... -
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- Understanding of epigenetics and DNA methylation
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Oh JH, Kwon YD, Yoon BW, Choi BJ
- KMID: 2118379
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2008 May;30(3):302-309.
Epigenetic is usually referring to heritable traits that do not involve changes to the underlying DNA sequence. DNA methylation is known to serve as cellular memory, and is one... -
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- p73 Methylation in Extranodal NK/T Cell Lympoma
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Cho MS
- KMID: 1964044
- Ewha Med J.
- 2005 Sep;28(2):83-86.
- doi: 10.12771/emj.2005.28.2.83
OBJECTIVES: DNA methylation of promoter-associated CpG islands is an epigenetic modification of DNA associanted with gene silencing. p73 is a member of the p 53 family which is a tumor... -
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- In silico Identification of SFRP1 as a Hypermethylated Gene in Colorectal Cancers
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Kim J, Kim S
- KMID: 2391493
- Genomics Inform.
- 2014 Dec;12(4):171-180.
- doi: 10.5808/GI.2014.12.4.171
Aberrant DNA methylation, as an epigenetic marker of cancer, influences tumor development and progression. We downloaded publicly available DNA methylation and gene expression datasets of matched cancer and normal pairs... -
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- DNA Methylation-Based Age Estimation in the Forensic Field
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An JH, Shin KJ, Choi A, Yang WI, Lee HY
- KMID: 2250272
- Korean J Leg Med.
- 2013 Feb;37(1):1-8.
- doi: 10.7580/kjlm.2013.37.1.1
The estimation of age is an important issue in forensic science, and the forensic community has attempted many times to establish methods for solving this issue. Aging leads to alterations... -
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- RUNX3 Methylation Status in Colonic Carcinoma and Adenoma
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Lee SN, Cho MS, Han WS
- KMID: 2275525
- Korean J Pathol.
- 2004 Feb;38(1):42-45.
BACKGROUND: RUNX3 is expressed throughout the luminal gastrointestinal tract. RUNX3 is on chromosome 1p36, a location considered to carry an important tumor suppressor for many types of cancers. Epigenetic silencing... -
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- A Two-DNA Methylation Signature to Improve Prognosis Prediction of Clear Cell Renal Cell Carcinoma
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Shi S, Ye S, Wu X, Xu M, Zhuo R, Liao Q, Xi Y
- KMID: 2460217
- Yonsei Med J.
- 2019 Nov;60(11):1013-1020.
- doi: 10.3349/ymj.2019.60.11.1013
PURPOSE: Effective biomarkers and models are needed to improve the prognostic prospects of clear cell renal cell carcinoma (ccRCC). The purpose of this work was to identify DNA methylation biomarkers... -
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- DNA methylation of Bcl-2 family genes in cancer cells
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Kang Y, Lee SY, Jung SG, Han J, Ko JJ, Bae J, Na YJ, Lee C, Mock JU, Kim SJ, Hwang YY
- KMID: 2273147
- Korean J Obstet Gynecol.
- 2007 Jul;50(7):997-1002.
OBJECTIVE: Promoter methylation of Bcl-2 family genes in cancer cells were studied to verify possible correlation between DNA methylation pattern of Bcl-2 family members and cancer. METHODS: The genomic DNAs... -
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- The Relationship between RUNX3 Inactivation and Its Pathological Features in Renal Cell Carcinoma
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Kwon WA, Park C, Kim EJ, Ha YS, Kim YJ, Yun SJ, Lee SC, Kim WJ
- KMID: 2311839
- Korean J Urol.
- 2009 May;50(5):432-438.
PURPOSE: DNA methylation is a key regulator of gene transcription and genomic stability, and alterations in DNA methylation are frequently detected in human tumors. Recent study has suggested that inactivation... -
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- Epigenetic Alterations in Inflammatory Bowel Disease and Cancer
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Yi JM, Kim TO
- KMID: 2284877
- Intest Res.
- 2015 Apr;13(2):112-121.
- doi: 10.5217/ir.2015.13.2.112
Overwhelming evidences supports the idea that inflammatory bowel disease (IBD) is caused by a complex interplay between genetic alterations of multiple genes and an aberrant interaction with environmental factors. There... -
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- DNA Methylation as Surrogate Marker For Gastric Cancer
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Oh JH, Jung SH, Hong SJ, Rhyu MG
- KMID: 2380867
- J Cancer Prev.
- 2015 Sep;20(3):172-178.
- doi: 10.15430/JCP.2015.20.3.172
Stomach cancer remains, stubbornly, highly prevalent in East Asia. Still, stomach cancer has few biomarkers by which it can be predicted. Helicobacter pylori infection, a known carcinogen of stomach cancer,... -
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- DNA Methylation Change of IL-4 Gene from T Cell in Allergic Children
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Oh JW, Yum MG, Kim CR, Seol IJ, Shin SA, Lee HB, Jang SJ
- KMID: 1763543
- Korean J Pediatr.
- 2005 Jun;48(6):634-639.
PURPOSE: An understanding of the immunological process is required if primary prevention of atopic diseases is to be developed in early childhood. But, it is too hard to distinguish atopy... -
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