Genomics Inform.
2011 Sep;9(3):136-137.
A Visualization Tool for Computational Analysis of DNA Methylation Level Using Bisulfite Sequencing Data
- Affiliations
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- 1Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA, The Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405, USA. mbio94@naver.com
Abstract
- Methylation of cytosine is a post-synthesis modification that does not affect the primary DNA sequence but greatly influences gene expression level and phenotypes of an organism. As high-throughput sequencing of bisulfite-treated DNA is the most efficient method to identify methylated sites, several tools to map sequencing reads on a reference are available. But tools to visualize and to interpret the methylation level of methylation sites are currently insufficient. Herein, we present a novel tool to visualize the methylation level of CpG sites.
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