- Enzymes involved in folate metabolism and its implication for cancer treatment
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Kim SE
- KMID: 2471876
- Nutr Res Pract.
- 2020 Apr;14(2):95-101.
- doi: 10.4162/nrp.2020.14.2.95
BACKGROUND/OBJECTIVES: Folate plays a critical role in DNA synthesis and methylation. Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and γ-glutamyl hydrolase (GGH). FPGS adds glutamate residues... -
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- Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes
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Lee J, Jang A, Seo SJ, Myung SC
- KMID: 2471338
- Ann Dermatol.
- 2020 Apr;32(2):122-129.
- doi: 10.5021/ad.2020.32.2.122
BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor... -
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- Characteristics of DNMT3A mutations in acute myeloid leukemia
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Park DJ, Kwon A, Cho BS, Kim HJ, Hwang KA, Kim M, Kim Y
- KMID: 2472004
- Blood Res.
- 2020 Mar;55(1):17-26.
- doi: 10.5045/br.2020.55.1.17
BACKGROUND: DNMT3A mutations occur in approximately 20% of AML cases and are associated with changes in DNA methylation. CDKN2B plays an important role in the regulation of hematopoietic progenitor cells... -
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- NOTCH1 Pathway is Involved in Polyhexamethylene Guanidine-Induced Humidifier Disinfectant Lung Injuries
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Lee E, Kang MJ, Kim JH, Lee SH, Lee SY, Cho HJ, Yoon J, Jung S, Park Y, Oh DK, Hong SB, Hong SJ
- KMID: 2468494
- Yonsei Med J.
- 2020 Feb;61(2):186-191.
- doi: 10.3349/ymj.2020.61.2.186
An outbreak of fatal humidifier disinfectant lung injuries (HDLI) occurred in Korea. Human studies on mechanisms underlying HDLI have yet to be conducted. This study aimed to investigate methylation changes... -
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- Epigenetic Changes in Asthma: Role of DNA CpG Methylation
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Bae DJ, Jun JA, Chang HS, Park JS, Park CS
- KMID: 2466615
- Tuberc Respir Dis.
- 2020 Jan;83(1):1-13.
- doi: 10.4046/trd.2018.0088
For the past three decades, more than a thousand of genetic studies have been performed to find out the genetic variants responsible for the risk of asthma. Until now, all... -
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- Clinical Effects of Hypomethylating Agents in Patients with Newly Diagnosed Myelodysplastic Syndrome Who Received DNA-Damaging Chemotherapy for Metastatic Breast Cancer
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Baek DW, Lee SJ, Sohn SK, Moon JH, Chae YS
- KMID: 2470901
- J Breast Cancer.
- 2019 Dec;22(4):647-652.
- doi: 10.4048/jbc.2019.22.e50
The cumulative risk of therapy-related myelodysplastic syndrome (t-MDS) in breast cancer patients exposed to chemotherapy and/or radiotherapy is significantly high compared to that in other cancer patients. This report reviews... -
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- Prognostic Role of KRAS mRNA Expression in Breast Cancer
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Hwang KT, Kim BH, Oh S, Park SY, Jung J, Kim J, Choi IS, Jeon SY, Kim WY
- KMID: 2470892
- J Breast Cancer.
- 2019 Dec;22(4):548-561.
- doi: 10.4048/jbc.2019.22.e55
PURPOSE: We investigated the prognostic role of KRAS mRNA expression in breast cancer using The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) databases. METHODS: Clinical... -
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- Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review
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Kim H, Kang JS, Jeong HJ
- KMID: 2470434
- Precis Future Med.
- 2019 Dec;3(4):139-145.
- doi: 10.23838/pfm.2019.00107
Arginine methylation mediated by protein arginine methyltransferases (PRMTs) has emerged as a key post-translational modification of histone or nonhistone substrates. It involves or controls signaling pathways or gene expression implicated... -
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- Identification and Characterization of Two New S-Adenosylmethionine-Dependent Methyltransferase Encoding Genes Suggested Their Involvement in Stipe Elongation of Flammulina velutipes
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Huang Q, Mukhtar I, Zhang Y, Wei Z, Han X, Huang R, Yan J, Xie B
- KMID: 2470176
- Mycobiology.
- 2019 Dec;47(4):441-448.
- doi: 10.1080/12298093.2019.1658332
Two new SAM-dependent methyltransferase encoding genes (fvsmt1 and fvsmt2) were identified from the genome of Flammulina velutipes. In order to make a comprehensive characterization of both genes, we performed in... -
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- DNA methylation: a cause and consequence of type 2 diabetes
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Kim M
- KMID: 2468864
- Genomics Inform.
- 2019 Dec;17(4):e38.
- doi: 10.5808/GI.2019.17.4.e38
DNA methylation is a relatively stable epigenetic modification that can regulate and stabilize gene expression patterns and hence establish cell identity. Because metabolic intermediates are key factors of DNA methylation... -
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- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells
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Kim D, Kim Y, Kim Y
- KMID: 2468812
- J Cancer Prev.
- 2019 Dec;24(4):224-232.
- doi: 10.15430/JCP.2019.24.4.224
BACKGROUND: Beta-carotene (BC) is a carotenoid which exerts anti-cancer effects in several types of cancer, including colorectal cancer. Epigenetic modifications of genes, such as histone deacetylation and DNA hypermethylation, have... -
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- FoxD2-AS1 is a prognostic factor in glioma and promotes temozolomide resistance in a Oâ¶-methylguanine-DNA methyltransferase-dependent manner
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Shangguan , Lv X, Tian N
- KMID: 2461040
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):475-482.
- doi: 10.4196/kjpp.2019.23.6.475
Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma... -
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- A Two-DNA Methylation Signature to Improve Prognosis Prediction of Clear Cell Renal Cell Carcinoma
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Shi S, Ye S, Wu X, Xu M, Zhuo R, Liao Q, Xi Y
- KMID: 2460217
- Yonsei Med J.
- 2019 Nov;60(11):1013-1020.
- doi: 10.3349/ymj.2019.60.11.1013
PURPOSE: Effective biomarkers and models are needed to improve the prognostic prospects of clear cell renal cell carcinoma (ccRCC). The purpose of this work was to identify DNA methylation biomarkers... -
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- Complementary Participation of Genetics and Epigenetics in Development of NSAID-exacerbated Respiratory Disease
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Lee JU, Park JS, Chang HS, Park CS
- KMID: 2459183
- Allergy Asthma Immunol Res.
- 2019 Nov;11(6):779-794.
- doi: 10.4168/aair.2019.11.6.779
Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) has attracted a great deal of attention because of its association with severe asthma. However, it remains widely underdiagnosed in asthmatics as well... -
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- Epigenetics and Depression: An Update
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Lin E, Tsai SJ
- KMID: 2459685
- Psychiatry Investig.
- 2019 Sep;16(9):654-661.
- doi: 10.30773/pi.2019.07.17.2
OBJECTIVE: Depression is associated with various environmental risk factors such as stress, childhood maltreatment experiences, and stressful life events. Current approaches to assess the pathophysiology of depression, such as epigenetics... -
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- Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster
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Park SY, Seo J, Chun YS
- KMID: 2455488
- J Korean Med Sci.
- 2019 Aug;34(33):e225.
- doi: 10.3346/jkms.2019.34.e225
BACKGROUND: Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. As... -
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- Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs
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Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F
- KMID: 2455043
- Tissue Eng Regen Med.
- 2019 Aug;16(4):335-343.
- doi: 10.1007/s13770-018-0172-4
BACKGROUND: Osteoarthritis (OA) is a highly prevalent degenerative joint disease involving joint cartilage and its surrounding tissues. OA is the leading cause of pain and disability worldwide. At present, there... -
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- Role of DNA Methylation in the Development and Differentiation of Intestinal Epithelial Cells and Smooth Muscle Cells
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Jorgensen , Ro S
- KMID: 2454636
- J Neurogastroenterol Motil.
- 2019 Jul;25(3):377-386.
- doi: 10.5056/jnm19077
The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has... -
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- CpG Island Methylation in Sessile Serrated Adenoma/Polyp of the Colorectum: Implications for Differential Diagnosis of Molecularly High-Risk Lesions among Non-dysplastic Sessile Serrated Adenomas/Polyps
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Lee JA, Park HE, Yoo SY, Jeong S, Cho NY, Kang GH, Kim JH
- KMID: 2454602
- J Pathol Transl Med.
- 2019 Jul;53(4):225-235.
- doi: 10.4132/jptm.2019.03.12
BACKGROUND: Although colorectal sessile serrated adenomas/polyps (SSA/Ps) with morphologic dysplasia are regarded as definite high-risk premalignant lesions, no reliable grading or risk-stratifying system exists for non-dysplastic SSA/Ps. The accumulation of... -
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- An investigation of methylation pattern changes in the IKZF1 promoter in patients with childhood B-cell acute lymphoblastic leukemia
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Rahmani M, Fardi M, Farshdousti Hagh M, Hosseinpour Feizi AA, Talebi M, Solali S
- KMID: 2451016
- Blood Res.
- 2019 Jun;54(2):144-148.
- doi: 10.5045/br.2019.54.2.144
BACKGROUND: Ikaros family zinc finger 1 (IKZF1) is a transcription factor with an important role in controlling hematopoietic proliferation and function, particularly lymphoid cell differentiation. It was previously shown that... -
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