- DNA Methylation in Development
-
Choe J
- KMID: 2184453
- J Genet Med.
- 2008 Dec;5(2):100-104.
DNA methylation is one of many epigenetic mechanisms that regulate gene expression in the human body. From the view of epigenetics, there are two phases of development, one for germ... -
- CITED
-
- Close
- SHARE
-
- Close
- A Visualization Tool for Computational Analysis of DNA Methylation Level Using Bisulfite Sequencing Data
-
Tae H
- KMID: 1806240
- Genomics Inform.
- 2011 Sep;9(3):136-137.
Methylation of cytosine is a post-synthesis modification that does not affect the primary DNA sequence but greatly influences gene expression level and phenotypes of an organism. As high-throughput sequencing of... -
- CITED
-
- Close
- SHARE
-
- Close
- Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers
-
Kondo Y
- KMID: 1758603
- Yonsei Med J.
- 2009 Aug;50(4):455-463.
- doi: 10.3349/ymj.2009.50.4.455
DNA methylation, histone modifications, and the chromatin structure are profoundly altered in human cancers. The silencing of cancer-related genes by these epigenetic regulators is recognized as a key mechanism in... -
- CITED
-
- Close
- SHARE
-
- Close
- DNA Methylation in Brain and Liver Tissues of Mice Infected with Scrapie Agent
-
Choi EK, Uyeno S, Ono T, Carp RI, Kim YS
- KMID: 1551980
- J Korean Soc Virol.
- 1998 Jun;28(2):183-192.
DNA methylation degree in the several murine brain and liver genes of different ages and after scrapie infection have been examined by using methylation-sensitive restriction endonuclease digestion. We found that... -
- CITED
-
- Close
- SHARE
-
- Close
- DNA methylation: a cause and consequence of type 2 diabetes
-
Kim M
- KMID: 2468864
- Genomics Inform.
- 2019 Dec;17(4):e38.
- doi: 10.5808/GI.2019.17.4.e38
DNA methylation is a relatively stable epigenetic modification that can regulate and stabilize gene expression patterns and hence establish cell identity. Because metabolic intermediates are key factors of DNA methylation... -
- CITED
-
- Close
- SHARE
-
- Close
- Prevalence and Clinical Significance of p15 Methylation in Acute Leukemia
-
Huh J, Chung W
- KMID: 2038251
- Korean J Lab Med.
- 2005 Apr;25(2):139-143.
BACKGROUND: CpG islands' methylation of p15 promoter region is associated with inactivation of the p15 gene, which negatively regulates the cell cycle. We investigated the prevalence and prog-nostic significance of... -
- CITED
-
- Close
- SHARE
-
- Close
- RUNX3 Methylation Status in Colonic Carcinoma and Adenoma
-
Lee SN, Cho MS, Han WS
- KMID: 2275525
- Korean J Pathol.
- 2004 Feb;38(1):42-45.
BACKGROUND: RUNX3 is expressed throughout the luminal gastrointestinal tract. RUNX3 is on chromosome 1p36, a location considered to carry an important tumor suppressor for many types of cancers. Epigenetic silencing... -
- CITED
-
- Close
- SHARE
-
- Close
- DNA methylation: an epigenetic mark of cellular memory
-
Kim M, Costello J
- KMID: 2382713
- Exp Mol Med.
- 2017 Apr;49(4):e322.
- doi: 10.1038/emm.2017.10
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell divisions. During development and cell differentiation, DNA methylation is dynamic, but some DNA methylation patterns may... -
- CITED
-
- Close
- SHARE
-
- Close
- Protein Methylation and Interaction with the Antiproliferative Gene, BTG2(/TIS21/Pc3)
-
Paik WK, Kim S, Lim IK
- KMID: 2386454
- Yonsei Med J.
- 2014 Mar;55(2):292-303.
The last one and half a decade witnessed an outstanding re-emergence of attention and remarkable progress in the field of protein methylation. In the present article, we describe the early... -
- CITED
-
- Close
- SHARE
-
- Close
- DNA Methylation in Lung Cancer
-
Lee MK
- KMID: 2200226
- J Lung Cancer.
- 2002 Dec;1(1):23-28.
DNA modification in vertebrate genomes is confined to the self-complementary sequence CpG. Between 60% and 90% of CpGs are methylated at the 5 position of cytosine, and the remainder is... -
- CITED
-
- Close
- SHARE
-
- Close
- Gene Methylation Associated with Differentiated Thyroid Cancer
-
Tae SY, Chi HK, Kim SJ, Lee KE, Youn YK
- KMID: 2095122
- J Korean Thyroid Assoc.
- 2014 Nov;7(2):118-128.
- doi: 10.11106/cet.2014.7.2.118
Epigenetic alteration changes expression of many genes, such as tumor suppressor gene and molecular specific gene, without change in DNA sequence. Cancers, including thyroid cancer, often exhibit an aberrant methylation... -
- CITED
-
- Close
- SHARE
-
- Close
- CpG island methylation and gynecolgic malignancy
-
Jeon YT, Kim JW, Kang SB
- KMID: 2244593
- Korean J Gynecol Oncol.
- 2005 Mar;16(1):1-7.
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- A Study on the Methylation of p 16 Gene Promotor in the Uterine Cervical Neoplasia
-
Bae DH, Kim MK, Lee CI, Kim CJ
- KMID: 2262067
- Korean J Obstet Gynecol.
- 2000 Sep;43(9):1525-1532.
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Disappearance of Serum Methylated p16 Indicates Longer Survival in Patients with Gastric Cancer
-
Lim HK, Park JM, Chi KC, Lee EJ, Jeong EM
- KMID: 2372464
- J Gastric Cancer.
- 2013 Sep;13(3):157-163.
PURPOSE: The aim of this study was to assess clinical correlations with postoperative alteration of p16 DNA methylation, and to clarify whether postoperative changes in the serum DNA methylation status... -
- CITED
-
- Close
- SHARE
-
- Close
- Writing, erasing and reading histone lysine methylations
-
Hyun K, Jeon J, Park K, Kim J
- KMID: 2382715
- Exp Mol Med.
- 2017 Apr;49(4):e324.
- doi: 10.1038/emm.2017.11
Histone modifications are key epigenetic regulatory features that have important roles in many cellular events. Lysine methylations mark various sites on the tail and globular domains of histones and their... -
- CITED
-
- Close
- SHARE
-
- Close
- In silico Identification of SFRP1 as a Hypermethylated Gene in Colorectal Cancers
-
Kim J, Kim S
- KMID: 2391493
- Genomics Inform.
- 2014 Dec;12(4):171-180.
- doi: 10.5808/GI.2014.12.4.171
Aberrant DNA methylation, as an epigenetic marker of cancer, influences tumor development and progression. We downloaded publicly available DNA methylation and gene expression datasets of matched cancer and normal pairs... -
- CITED
-
- Close
- SHARE
-
- Close
- Cysteine carboxyl O-methylation of human placental 23 kDa protein
-
Hong KM, Choi YB, Hong JH, Chang HS, Rhee KI, Park H, Paik MK
- KMID: 755024
- Exp Mol Med.
- 1999 Mar;31(1):30-35.
C-Terminal carboxyl methylation of a human placental 23 kDa protein catalyzed by membrane-associated methyltransferase has been investigated. The 23 kDa protein substrate methylated was partially purified by DEAE-Sephacel, hydroxyapatite and Sephadex G-100 gel... -
- CITED
-
- Close
- SHARE
-
- Close
- The Relationship between RUNX3 Inactivation and Its Pathological Features in Renal Cell Carcinoma
-
Kwon WA, Park C, Kim EJ, Ha YS, Kim YJ, Yun SJ, Lee SC, Kim WJ
- KMID: 2311839
- Korean J Urol.
- 2009 May;50(5):432-438.
PURPOSE: DNA methylation is a key regulator of gene transcription and genomic stability, and alterations in DNA methylation are frequently detected in human tumors. Recent study has suggested that inactivation... -
- CITED
-
- Close
- SHARE
-
- Close
- Promoter Methylation of p16 Gene in Cervical Cancer
-
Jeong DH, Youm MY, Park HK, Kim YN, Lee KB, Sung MS, Kim KT, Kim HC
- KMID: 2244595
- Korean J Gynecol Oncol.
- 2005 Mar;16(1):21-26.
OBJECTIVE: To investigate the promoter methylation status in the p16 gene in primary cervical cancer and to analyze the relationships between the clinicopathologic parameters and the methylation status of p16... -
- CITED
-
- Close
- SHARE
-
- Close
- Aberrant DNA Methylation of CDH1, p16 and DAPK in Childhood Acute Lymphoblastic Leukemia
-
Hahn SM, Kwon SY, Kim HS, Han JW, Lyu CJ
- KMID: 2168921
- Clin Pediatr Hematol Oncol.
- 2015 Apr;22(1):60-66.
- doi: 10.15264/cpho.2015.22.1.60
BACKGROUND: Hypermethylation of tumor suppressor gene has been reported in various types of leukemia with potential involvement in the inactivation of regulatory cell cycle and apoptosis genes. METHODS: To evaluate the... -
- CITED
-
- Close
- SHARE
-
- Close
