Ewha Med J.  2005 Sep;28(2):83-86. 10.12771/emj.2005.28.2.83.

p73 Methylation in Extranodal NK/T Cell Lympoma

• Cho MS

• KMID: 1964044
• DOI: http://doi.org/10.12771/emj.2005.28.2.83

Abstract

OBJECTIVES
DNA methylation of promoter-associated CpG islands is an epigenetic modification of DNA associanted with gene silencing. p73 is a member of the p 53 family which is a tumor suppressor gene producing apoptosis and cell cycel arrest. We investigated the methylation pattern of p73 on the cases diagnosed at Ewha university hospital between 1993-2002. MATERIAL AND METHODS: Sixteen cases of NK/T cell lymphomas and 7 cases of normal controls, which were 2 cases of peripheral blood mononuclear cells and 5 cases of nasal mucosal tissue were studied. Methylation-speific PCR for p73 were done.
RESULTS
All cases of NK/T cell lymphomas except one(93.8%) showed hypermethylation of p73. Six cases among 7 normal control cases(14.2%) revealed unmethylated p73.
CONCLUSION
This results suggested that inactivation of p73 could be associated with tumorigenesis of NK cells.

Keyword

p73; NK/T cell lymphoma; Extranodal

MeSH Terms

Apoptosis
Carcinogenesis
CpG Islands
DNA
DNA Methylation
Epigenomics
Gene Silencing
Genes, Tumor Suppressor
Humans
Killer Cells, Natural
Lymphoma
Methylation*
Mucous Membrane
Polymerase Chain Reaction
DNA