- CpG Islands Detector: a Window-based CpG Island Search Tool
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Kim KB
- KMID: 2166478
- Genomics Inform.
- 2010 Mar;8(1):58-61.
CpG is the pair of nucleotides C and G, appearing successively, in this order, along one DNA strand. It is known that due to biochemical considerations CpG is relatively rare... -
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- Understanding of epigenetics and DNA methylation
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Oh JH, Kwon YD, Yoon BW, Choi BJ
- KMID: 2118379
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2008 May;30(3):302-309.
Epigenetic is usually referring to heritable traits that do not involve changes to the underlying DNA sequence. DNA methylation is known to serve as cellular memory, and is one... -
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- CpG island methylation and gynecolgic malignancy
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Jeon YT, Kim JW, Kang SB
- KMID: 2244593
- Korean J Gynecol Oncol.
- 2005 Mar;16(1):1-7.
No abstract available. -
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- Prognostic Significance of CpG Island Methylator Phenotype in Colorectal Cancer
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Joo YE
- KMID: 2380755
- Gut Liver.
- 2015 Mar;9(2):139-140.
- doi: 10.5009/gnl15023
No abstract available. -
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- CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions
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Kang GH
- KMID: 1439767
- Korean J Pathol.
- 2012 Feb;46(1):1-9.
- doi: 10.4132/KoreanJPathol.2012.46.1.1
Gastric cancers arise through a multistep process characterized by the progressive accumulation of molecular alterations in which genetic and epigenetic mechanisms have been implicated. Gastric cancer is one of the... -
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- DNA Methylation in Lung Cancer
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Lee MK
- KMID: 2200226
- J Lung Cancer.
- 2002 Dec;1(1):23-28.
DNA modification in vertebrate genomes is confined to the self-complementary sequence CpG. Between 60% and 90% of CpGs are methylated at the 5 position of cytosine, and the remainder is... -
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- DNA Methylation and Expression Patterns of Key Tissue-specific Genes in Adult Stem Cells and Stomach Tissues
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Hong SJ, Kang MI, Oh JH, Jung YC, Kim YH, Kim SJ, Choi SH, Seo EJ, Choi SW, Rhyu MG
- KMID: 1782016
- J Korean Med Sci.
- 2009 Oct;24(5):918-929.
- doi: 10.3346/jkms.2009.24.5.918
CpG-island margins and non-island-CpG sites round the transcription start sites of CpG-island-positive and -negative genes are methylated to various degrees in a tissue-specific manner. These methylation-variable CpG sites were analyzed... -
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- DNA Methylation Changes in Human Cancers
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Kwon HJ, Kang GH
- KMID: 2244887
- J Genet Med.
- 2009 Jun;6(1):1-7.
Epigenetic changes represented by promoter CpG island hypermethylation and histone modification are an important carcinogenetic mechanism, which is found in virtually all histologic types of human cancer. About 60-70% of... -
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- DNA Methylation as Surrogate Marker For Gastric Cancer
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Oh JH, Jung SH, Hong SJ, Rhyu MG
- KMID: 2380867
- J Cancer Prev.
- 2015 Sep;20(3):172-178.
- doi: 10.15430/JCP.2015.20.3.172
Stomach cancer remains, stubbornly, highly prevalent in East Asia. Still, stomach cancer has few biomarkers by which it can be predicted. Helicobacter pylori infection, a known carcinogen of stomach cancer,... -
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- CpG Island Methylation According to the Histologic Patterns of Early Gastric Adenocarcinoma
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Choi J, Cho MY, Jung SY, Jan KM, Kim HS
- KMID: 1443696
- Korean J Pathol.
- 2011 Oct;45(5):469-476.
- doi: 10.4132/KoreanJPathol.2011.45.5.469
BACKGROUND: Although the importance of aberrant DNA methylation in the development of gastric adenocarcinoma has been described, the mechanism of pathogenesis has not been revealed yet. We quantitatively analyzed methylation... -
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- Cloning of Notl-linked DNA Detected by Restriction Landmark Genomic Scanning of Human Genome
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Kim JH, Lee KT, Kim HC, Yang JO, Hahn YS, Kim SS, Kim SY, Yoo HS, Kim YS
- KMID: 2166188
- Genomics Inform.
- 2006 Mar;4(1):1-10.
Epigenetic alterations are common features of human solid tumors, though global DNA methylation has been difficult to assess. Restriction Landmark Genomic Scanning (RLGS) is one of technology to examine epigenetic... -
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- DNA Methylation of Gene Expression in Acanthamoeba castellanii Encystation
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Moon EK, Hong Y, Lee HA, Quan FS, Kong HH
- KMID: 2379412
- Korean J Parasitol.
- 2017 Apr;55(2):115-120.
- doi: 10.3347/kjp.2017.55.2.115
Encystation mediating cyst specific cysteine proteinase (CSCP) of Acanthamoeba castellanii is expressed remarkably during encystation. However, the molecular mechanism involved in the regulation of CSCP gene expression remains unclear. In... -
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- Chromosomal Losses are Associated with Hypomethylation of the Gene-Control Regions in the Stomach with a Low Number of Active Genes
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Jung YC, Hong SJ, Kim YH, Kim SJ, Kang SJ, Choi SW, Rhyu MG
- KMID: 1107535
- J Korean Med Sci.
- 2008 Dec;23(6):1068-1089.
- doi: 10.3346/jkms.2008.23.6.1068
Transitional-CpG methylation between unmethylated promoters and nearby methylated retroelements plays a role in the establishment of tissue-specific transcription. This study examined whether chromosomal losses reducing the active genes in cancers... -
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- Cancer Epigenetics
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Chang DK
- KMID: 1113291
- Korean J Gastroenterol.
- 2004 Jul;44(1):1-12.
Knowledge regarding molecular events of cancer development has been rapidly accumulated during the last decade. The discovery of tumor suppressor gene-silencing by aberrant promoter CpG island hypermethylation and histone-directed chromatin... -
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- p73 Methylation in Extranodal NK/T Cell Lympoma
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Cho MS
- KMID: 1964044
- Ewha Med J.
- 2005 Sep;28(2):83-86.
- doi: 10.12771/emj.2005.28.2.83
OBJECTIVES: DNA methylation of promoter-associated CpG islands is an epigenetic modification of DNA associanted with gene silencing. p73 is a member of the p 53 family which is a tumor... -
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- HOTAIR Long Non-coding RNA: Characterizing the Locus Features by the In Silico Approaches
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Hajjari M, Rahnama S
- KMID: 2404055
- Genomics Inform.
- 2017 Dec;15(4):170-177.
- doi: 10.5808/GI.2017.15.4.170
HOTAIR is an lncRNA that has been known to have an oncogenic role in different cancers. There is limited knowledge of genetic and epigenetic elements and their interactions for the... -
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- The Relationship between the Methylenetetrahydrofolate Reductase Genotypes and the Methylation Status of the CpG Island Loci, LINE-1 and Alu in Prostate Adenocarcinoma
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Kim JH, Cho NY, Kim BH, Kim WY, Kim BS, Moon KC, Kang GH
- KMID: 1472551
- Korean J Pathol.
- 2009 Feb;43(1):26-35.
- doi: 10.4132/KoreanJPathol.2009.43.1.26
BACKGROUND: Genetic polymorphism of methylenetetrahydrofolate reductase (MTHFR), in association with the influence of MTHFR upon DNA methylation, may cause differences of the methylation profile of cancer. Thus, we investigated the... -
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- Progressive De Novo DNA Methylation at the Pa Promotor of the Abl Genein the Bcr-Abl Locus during the Course of Chronic Myelogenous Leukemia
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Yang SE, Chi HS
- KMID: 2089552
- Korean J Clin Pathol.
- 1998 Sep;18(3):480-486.
BACKGROUND: In most cases of chronic myelogenous leukemia (CML), one of the two abl promotors (Pa) is nested within the bcr-abl hybrid gene and should be able to transcribe the... -
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- Screening Relevance of Sessile Serrated Polyps
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Kahi CJ
- KMID: 2449762
- Clin Endosc.
- 2019 May;52(3):235-238.
- doi: 10.5946/ce.2018.112
Conventional adenomas have historically been considered to be the only screening-relevant colorectal cancer (CRC) precursor lesion. The prevailing paradigm was that most CRCs arise along the chromosomal instability pathway, where... -
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- Aberrant CpG Islands Hypermethylation Profiles in Malignant Gliomas
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Kim KR, Kim E, Son EI
- KMID: 1734665
- Brain Tumor Res Treat.
- 2014 Apr;2(1):29-35.
- doi: 10.14791/btrt.2014.2.1.29
BACKGROUND: The authors analyzed whether the promoter hypermethylation of cancer-related genes was involved in the tumorigenesis of malignant gliomas. METHODS: A total of 29 patients received surgery and histologically confirmed to... -
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