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Bibliometric analysis of studies about acute myeloid leukemia conducted globally from 1999 to 2018

Seo B, Kim J, Kim S, Lee E

A bibliometric study is performed to analyze publication patterns in a specific research area and to establish a landscape model that can be used to quantitatively weigh publications. This study...
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IL-17-Producing Cells in Tumor Immunity: Friends or Foes?

Kuen DS, Kim BS, Chung Y

IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is...
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Cohort Profile: Firefighter Research on the Enhancement of Safety and Health (FRESH), a Prospective Cohort Study on Korean Firefighters

Kim YT, Kim WJ, Choi JE, Bae MJ, Jang H, Lee CJ, Lee HJ, Im DJ, Ye BS, Kim MJ, Jeong Y, Oh SS, Jung YC, Kang ES, Park S, Lee SK, Park KS, Koh SB, Kim C

Firefighters have a high risk of developing cardiovascular and mental disorders due to their physical and chemical environments. However, in Korea, few studies have been conducted on environmental risk of...
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Cellular immunotherapy in multiple myeloma

Vo MC, Lakshmi TJ, Jung SH, Cho D, Park HS, Chu TH, Lee HJ, Kim HJ, Kim SK, Lee JJ

In multiple myeloma (MM), the impaired function of several types of immune cells favors the tumor’s escape from immune surveillance and, therefore, its growth and survival. Tremendous improvements have been...
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Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects

Pei CZ, Kim YJ, Baek KH

Recurrent pregnancy loss (RPL) is a common complication in obstetrics, affecting about 5% of women of childbearing age. An increase in the number of abortions results in escalation in the...
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Natural Killer Cells and Thyroid Diseases

Lee EK, Sunwoo JB

Abnormal production of thyroid hormone is one of the common endocrine disorders, and thyroid hormone production declines with age. The aging process also negatively affects the immune system. An interaction...
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Effects of Cordyceps militaris supplementation on the immune response and upper respiratory infection in healthy adults: a randomized, double-blind, placebo-controlled study

Jung SJ, Hwang JH, Oh MR, Chae SW

PURPOSE: Upper respiratory tract infections are major causes of the common cold throughout the world. Cordyceps militaris (C. militaris) is a well-known functional food for its anti-fatigue and immunomodulating activities....
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MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1

Yang Q, Li J, Hu Y, Tang X, Yu L, Dong L, Chen D

PURPOSE: Lung adenocarcinoma (LA) is one of the major types of lung cancer. MicroRNAs (miRNAs) play an essential role in regulating responses of natural killer (NK) cells to cancer malignancy....
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Development of a Novel Flow Cytometry-Based System for White Blood Cell Differential Counts: 10-color LeukoDiff

Park D, Chang J, Kahng J, Park H, Jo I, Kim Y, Han K

BACKGROUND: Flow cytometry (FCM) is commonly used to identify many cell populations. We developed a white blood cell (WBC) differential counting system for detecting abnormal cells using FCM incorporating 10...
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Potential Implications of Long Noncoding RNAs in Autoimmune Diseases

Hur K, Kim SH, Kim JM

Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200 nucleotides in length. Despite the term “noncoding”, lncRNAs have been reported to be involved in gene expression. Accumulating...
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Cancer Conditioned Medium Modulates Functional and Phenotypic Properties of Human Decidua Parietalis Mesenchymal Stem/Stromal Cells

Bahattab E, Khatlani T, Abomaray F, Messaoudi , Abumaree M

BACKGROUND: Mesenchymal Stem/Stromal Cells (MSCs) from the decidua parietalis (DPMSCs) of human term placenta express several molecules with important biological and immunological properties. DPMSCs induce natural killer cell expression of...
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Splenocyte-mediated immune enhancing activity of Sargassum horneri extracts

Kim DS, Sung NY, Han IJ, Lee BS, Park SY, Nho EY, Eom J, Kim G, Kim KA

PURPOSE: This study examined the immunological activity and optimized the mixture conditions of Sargassum horneri (S. horneri) extracts in vitro and in vivo models. METHODS: S. horneri was extracted using three...
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A Boy with Chronic Active EBV Infection Presented as Mosquito Bite Hypersensitivity Progressed to Fatal Hemophagocytic Lymphohistiocytosis due to NK Cell Neoplasm

Lee JA, Han SB, Chung NG, Kang JH, Kim M, Jeong DC

Chronic active Epstein-Barr virus (CAEBV) infection is characterized by recurrent infectious mononucleosis (IM)-like symptoms and an unusual pattern of anti-EBV antibodies. We report a boy with CAEBV who progressed to...
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Effect of immune-enhancing enteral nutrition formula enriched with plant-derived n-3 fatty acids on natural killer cell activity in rehabilitation patients

Cho JM, Choi HS, Cho YS, Park SY, Kim DY, Lee JH

BACKGROUND/OBJECTIVES: Enteral nutrition formulas with immune-enhancing nutrients, such as n-3 fatty acids, may manage patients' nutritional status and pathophysiological processes. The aim of our study was to investigate natural killer...
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MiR-506 Promotes Natural Killer Cell Cytotoxicity against Human Hepatocellular Carcinoma Cells by Targeting STAT3

Su Z, Ye X, Shang L

PURPOSE: It is well documented that natural killer (NK) cytotoxicity against hepatocellular carcinoma (HCC) cells is impaired in HCC, which might account for the failure of anti-tumor immune response. miRNAs...
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The prognostic impact of lymphocyte subsets in newly diagnosed acute myeloid leukemia

Park Y, Lim J, Kim S, Song I, Kwon K, Koo S, Kim J

BACKGROUND: Tumor-infiltrating lymphocytes, which form a part of the host immune system, affect the development and progression of cancer. This study investigated whether subsets of lymphocytes reflecting host-tumor immunologic interactions...
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Role of Natural Killer Cells in Airway Inflammation

Kim JH, Jang YJ

Natural killer (NK) cells have an immune regulatory function as well as cytotoxicity against tumor or infected cells. In the airway, although NK cells constitute a small proportion of the...
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Optimization of Large-Scale Expansion and Cryopreservation of Human Natural Killer Cells for Anti-Tumor Therapy

Min B, Choi H, Her JH, Jung MY, Kim HJ, Jung MY, Lee EK, Cho SY, Hwang YK, Shin EC

Allogeneic natural killer (NK) cell therapy is a potential therapeutic approach for a variety of solid tumors. We established an expansion method for large-scale production of highly purified and functionally...
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CD57 (Leu-7, HNK-1) immunoreactivity seen in thin arteries in the human fetal lung

Ishizuka S, Jin ZW, Yamamoto M, Murakami G, Takayama T, Hayashi K, Abe SI

CD57 (synonyms: Leu-7, HNK-1) is a well-known marker of nerve elements including the conductive system of the heart, as well as natural killer cells. In lung specimens from 12 human...
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Physical Inactivity and Unhealthy Metabolic Status Are Associated with Decreased Natural Killer Cell Activity

Jung YS, Park JH, Park DI, Sohn CI, Lee JM, Kim TI

PURPOSE: Several studies have reported relationships among physical activity, healthy metabolic status, and increased natural killer (NK) cell activity. However, large-scale data thereon are lacking. Thus, the present study aimed...
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