- The Role of Gut Microbiota and Genetic Susceptibility in the Pathogenesis of Pancreatitis
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Xu F, Yang C, Tang M, Wang M, Cheng Z, Chen D, Chen X, Liu K
- KMID: 2533177
- Gut Liver.
- 2022 Sep;16(5):686-696.
- doi: 10.5009/gnl210362
Pancreatitis is one of the most common inflammatory diseases of the pancreas caused by autodigestion induced by excessive premature protease activation. However, recognition of novel pathophysiological mechanisms remains a still... -
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- Application of Next Generation Sequencing in Laboratory Medicine
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Zhong Y, Xu F, Wu J, Schubert J, Li MM
- KMID: 2512731
- Ann Lab Med.
- 2021 Jan;41(1):25-43.
- doi: 10.3343/alm.2021.41.1.25
The rapid development of next-generation sequencing (NGS) technology, including advances in sequencing chemistry, sequencing technologies, bioinformatics, and data interpretation, has facilitated its wide clinical application in precision medicine. This review... -
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- Optimization of Submerged Fermentation Medium for Matrine Production by Aspergillus terreus, an Endophytic Fungus Harboring Seeds of Sophora flavescens, Using Response Surface Methodology
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Zhang Q, Li Y, Xu F, Zheng M, Xi X, Zhang X, Han C
- KMID: 2385656
- Mycobiology.
- 2017 Jun;45(2):90-96.
- doi: 10.5941/MYCO.2017.45.2.90
Different endophytes isolated from the seeds of Sophora flavescens were tested for their ability to produce matrine production. Response surface methodology (RSM) was applied to optimize the medium components for... -
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- Surgical Treatment of Ten Adults with Spinal Extradural Meningeal Cysts in the Thoracolumbar Spine
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Xu F, Jian F, Li L, Guan J, Chen Z
- KMID: 2513854
- J Korean Neurosurg Soc.
- 2021 Mar;64(2):238-246.
- doi: 10.3340/jkns.2020.0244
Objective : To retrospectively analyze the clinical characteristics and surgical experience of 10 adults with spinal extradural meningeal cysts (SEMCs) in the thoracolumbar spine which may further provide evidence for... -
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- A comparison of the diagnostic performance of the O-RADS, RMI4, IOTA LR2, and IOTA SR systems by senior and junior doctors
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Guo Y, Zhao B, Zhou S, Wen L, Liu J, Fu Y, Xu F, Liu M
- KMID: 2531439
- Ultrasonography.
- 2022 Jul;41(3):511-518.
- doi: 10.14366/usg.21237
Purpose: This study compared the diagnostic performance of the Ovarian-Adnexal Reporting and Data System (O-RADS), the Risk of Malignancy Index 4 (RMI4), the International Ovarian of Tumor Analysis Logistic Regression... -
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- Increased Wall Enhancement Extent Representing Higher Rupture Risk of Unruptured Intracranial Aneurysms
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Jiang Y, Xu F, Huang L, Lu G, Ge L, Wan H, Geng D, Zhang X
- KMID: 2513849
- J Korean Neurosurg Soc.
- 2021 Mar;64(2):189-197.
- doi: 10.3340/jkns.2020.0144
Objective : This study aims to investigate the relationship between aneurysm wall enhancement and clinical rupture risks based on the magnetic resonance vessel wall imaging (MR-VWI) quantitative methods. Methods : One... -
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- Involvement of Estrogen Receptor-α in the Activation of Nrf2-Antioxidative Signaling Pathways by Silibinin in Pancreatic β-Cells
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Chu C, Gao X, Li X, Zhang X, Ma R, Jia Y, Li D, Wang D, Xu F
- KMID: 2507837
- Biomol Ther.
- 2020 Mar;28(2):163-171.
- doi: 10.4062/biomolther.2019.071
Silibinin exhibits antidiabetic potential by preserving the mass and function of pancreatic β-cells through up-regulation of estrogen receptor-α (ERα) expression. However, the underlying protective mechanism of silibinin in pancreatic β-cells... -
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- EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations
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Zhou W, Jiang Z, Li X, Xu F, Liu Y, Wen P, Kong L, Hou M, Yu J
- KMID: 1794413
- J Korean Med Sci.
- 2009 Feb;24(1):97-103.
- doi: 10.3346/jkms.2009.24.1.97
Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule with important roles in the regulation of apoptosis, differentiation and invasion of cancer cells, but the detailed is largely still... -
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- MicroRNA-145-5p Regulates the Epithelial-Mesenchymal Transition in Nasal Polyps by Targeting Smad3
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Zhang M, Peng X, Liang X, Wang W, Yang Y, Xu F, Lu X, Geng D, Li M
- KMID: 2556003
- Clin Exp Otorhinolaryngol.
- 2024 May;17(2):122-136.
- doi: 10.21053/ceo.2023.00025
Objectives. The annual prevalence of chronic rhinosinusitis (CRS) is increasing, and the lack of effective treatments imposes a substantial burden on both patients and society. The formation of nasal polyps... -
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- Operable Breast Cancer of the Inner Hemisphere Is Associated with Poor Survival
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Xue C, Peng RJ, Wang SS, Shi YX, An X, Xu F, Yuan ZY
- KMID: 2286335
- J Breast Cancer.
- 2015 Mar;18(1):36-43.
- doi: 10.4048/jbc.2015.18.1.36
PURPOSE: This study investigated the clinicopathological features of operable breast cancer lesions located in different hemispheres of the breast and determined related survival outcomes. METHODS: Data from 5,330 patients with invasive... -
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- Screening Tools Based on Nomogram for Diabetic Kidney Diseases in Chinese Type 2 Diabetes Mellitus Patients
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Wang G, Wang B, Qiao G, Lou H, Xu F, Chen Z, Chen S
- KMID: 2520853
- Diabetes Metab J.
- 2021 Sep;45(5):708-718.
- doi: 10.4093/dmj.2020.0117
Background: The influencing factors of diabetic kidney disease (DKD) in Chinese patients with type 2 diabetes mellitus (T2DM) were explored to develop and validate a DKD diagnostic tool based on... -
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- Neuroprotective Effects of Spinosin on Recovery of Learning and Memory in a Mouse Model of Alzheimer's Disease
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Xu F, He B, Xiao F, Yan T, Bi K, Jia Y, Wang Z
- KMID: 2432069
- Biomol Ther.
- 2019 Jan;27(1):71-77.
- doi: 10.4062/biomolther.2018.051
Previous studies have shown that spinosin was implicated in the modulation of sedation and hypnosis, while its effects on learning and memory deficits were rarely reported. The aim of this... -
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- Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway
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Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y
- KMID: 2500502
- Biomol Ther.
- 2020 May;28(3):259-266.
- doi: 10.4062/biomolther.2019.123
The present research work primarily investigated whether spinosin has the potential of improving the pathogenesis of Alzheimer’s disease (AD) driven by β-amyloid (Aβ) overproduction through impacting the procession of amyloid... -
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- Clinical and Pathologic Features of Multifocal and Multicentric Breast Cancer in Chinese Women: A Retrospective Cohort Study
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Zhou MR, Tang ZH, Li J, Fan JH, Pang Y, Yang HJ, Zheng S, Bai JQ, Lv N, Qiao YL, Qi HZ, Xu F
- KMID: 2374549
- J Breast Cancer.
- 2013 Mar;16(1):77-83.
PURPOSE: This study aims to analyze the clinical-pathological characteristics of multifocal and multicentric breast cancer (MMBC) in Chinese women. METHODS: Sixty-seven cases with MMBC were randomly collected and reviewed at seven... -
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- The Effect of an Ectopic Overexpression of MnSOD in Mouse Hematopoietic Stem Cells
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Park MR, Xu F, Cheng T
- KMID: 2252152
- Korean J Hematol.
- 2009 Jun;44(2):82-91.
- doi: 10.5045/kjh.2009.44.2.82
BACKGROUND: Intracellular reactive oxygen species (ROS) have dual effects depending on their cellular level. ROS act as secondary messengers at a low concentration, although ROS exhaust the hematopoietic stem cell... -
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- Associations of Plasma Glucagon Levels with Estimated Glomerular Filtration Rate, Albuminuria and Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus
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Huang HX, Shen LL, Huang HY, Zhao LH, Xu F, Zhang DM, Zhang XL, Chen T, Wang XQ, Xie Y, Su JB
- KMID: 2522726
- Diabetes Metab J.
- 2021 Nov;45(6):868-879.
- doi: 10.4093/dmj.2020.0149
Background: Type 2 diabetes mellitus (T2DM) is characterized by elevated fasting glucagon and impaired suppression of postprandial glucagon secretion, which may participate in diabetic complications. Therefore, we investigated the associations... -
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- Effect of Heart Rate and Coronary Calcification on the Diagnostic Accuracy of the Dual-Source CT Coronary Angiography in Patients with Suspected Coronary Artery Disease
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Meng L, Cui L, Cheng Y, Wu X, Tang Y, Wang Y, Xu F
- KMID: 1777262
- Korean J Radiol.
- 2009 Aug;10(4):347-354.
- doi: 10.3348/kjr.2009.10.4.347
OBJECTIVE: To evaluate the diagnostic accuracy of a dual-source computed tomography (DSCT) coronary angiography, with a particular focus on the effect of heart rate and calcifications. MATERIALS AND METHODS:One hundred... -
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- Pyrotinib Combined with Vinorelbine in Patients with Previously Treated HER2-Positive Metastatic Breast Cancer: A Multicenter, Single-Arm, Prospective Study
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Jiang K, Hong R, Xia W, Lu Q, Li L, Huang J, Shi Y, Yuan Z, Zheng Q, An X, Xue C, Huang J, Bi X, Chen M, Zhang J, Xu F, Wang S
- KMID: 2554340
- Cancer Res Treat.
- 2024 Apr;56(2):513-521.
- doi: 10.4143/crt.2023.786
Purpose This study aims to evaluate the efficacy and safety of a new combination treatment of vinorelbine and pyrotinib in human epidermal growth factor receptor 2 (HER2)–positive metastatic breast cancer... -
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