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Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases

Oh SJ, Choi YK, Shin OS

Emerging infectious diseases (EIDs) pose a major threat to public health and security. Given the dynamic nature and significant impact of EIDs, the most effective way to prevent and protect...
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The Immunogenicity and Safety of a Combined DTaP-IPV//Hib Vaccine Compared with Individual DTaP-IPV and Hib (PRP~T) Vaccines: a Randomized Clinical Trial in South Korean Infants

Kang JH, Lee HJ, Kim KH, Oh SH, Cha SH, Lee J, Kim NH, Eun BW, Kim CH, Hong YJ, Kim HH, Lee KY, Kim YJ, Cho EY, Kim HS, Guitton F, Ortiz E

Recommended infant vaccination in Korea includes DTaP-IPV and Hib vaccines administered as separate injections. In this randomized, open, controlled study we assessed the non-inferiority of immunogenicity of DTaP-IPV//Hib pentavalent combination...
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Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013

Cho EY, Choi EH, Kang JH, Kim KH, Kim DS, Kim YJ, Ahn YM, Eun BW, Oh SH, Cha SH, Cho HK, Hong YJ, Kim KN, Kim NH, Kim YK, Kim JH, Lee H, Lee T, Kim HM, Lee KS, Kim CS, Park SE, Kim YM, Oh CE, Ma SH, Jo DS, Choi YY, Lee J, Bae GR, Park O, Park YJ, Kim ES, Lee HJ

This study was performed to measure early changes in the serotype distribution of pneumococci isolated from children with invasive disease during the 3-year period following the introduction of 10- and...
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Perception and Attitudes of Korean Obstetricians about Maternal Influenza Vaccination

Noh JY, Seo YB, Song JY, Choi WS, Lee J, Jung E, Kang S, Choi MJ, Jun J, Yoon JG, Lee SN, Hyun H, Lee JS, Cheong H, Cheong HJ, Kim WJ

Pregnant women are prioritized to receive influenza vaccination. However, the maternal influenza vaccination rate has been low in Korea. To identify potential barriers for the vaccination of pregnant women against...
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Increased humoral antibody response of foot-and-mouth disease virus vaccine in growing pigs pre-treated with poly-γ-glutamic acid

Lee JH, Kang IJ, Kim AR, Noh YS, Chung HC, Park BK

This study was conducted to determine if humoral antibody response of foot-and-mouth disease (FMD) vaccine improved in 8-week-old growing pigs born to well-vaccinated sows pre-treated with 60 mg of poly-γ-glutamic...
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Impact of IgM Antibodies on Cross-Protection against Pneumococcal Serogroups 6 and 19 after Immunization with 7-Valent Pneumococcal Conjugate Vaccine in Children

Cho HK, Park IH, Burton RL, Kim KH

Although it is well known that pneumococcal conjugate vaccines provide cross-protection against some vaccine-related serotypes, these mechanisms are still unclear. This study was performed to investigate the role of cross-protective...
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Influenza Vaccination Coverage Rate according to the Pulmonary Function of Korean Adults Aged 40 Years and Over: Analysis of the Fifth Korean National Health and Nutrition Examination Survey

Cha SH, Paik JH, Lee MR, Yang H, Park SG, Jeon YJ, Yoo S

Influenza vaccination is an effective strategy to reduce morbidity and mortality, particularly for those who have decreased lung functions. This study was to identify the factors that affect vaccination coverage...
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A novel M2e-multiple antigenic peptide providing heterologous protection in mice

Wen F, Ma JH, Yu H, Yang FR, Huang M, Zhou YJ, Li ZJ, Wang XH, Li GX, Jiang YF, Tong W, Tong GZ

Swine influenza viruses (SwIVs) cause considerable morbidity and mortality in domestic pigs, resulting in a significant economic burden. Moreover, pigs have been considered to be a possible mixing vessel in...
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Assessment of the safety and efficacy of low pathogenic avian influenza (H9N2) virus in inactivated oil emulsion vaccine in laying hens

Shin JH, Mo JS, Kim JN, Mo IP, Ha BD

In Korea, several outbreaks of low pathogenic AI (H9N2) viral infections leading to decreased egg production and increased mortality have been reported on commercial farms since 1996, resulting in severe...
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The Immunogenicity and Safety of the Live-attenuated SA 14-14-2 Japanese Encephalitis Vaccine Given with a Two-dose Primary Schedule in Children

Kwon HJ, Lee SY, Kim KH, Kim DS, Cha SH, Jo DS, Kang JH

Effective and tolerable vaccination is an essential strategy to prevent Japanese encephalitis (JE) in endemic areas. Although the live attenuated SA 14-14-2 JE vaccine (LAJEV) has been widely used since...
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Assessing PCV2 antibodies in field pigs vaccinated with different porcine circovirus 2 vaccines using two commercial ELISA systems

Shin MK, Yoon SH, Kim MH, Lyoo YS, Suh SW, Yoo HS

Porcine circovirus type 2 (PCV2) is the primary causative agent for post-weaning, multisystemic, wasting syndrome. Consequently, serologic detection of and vaccination against PCV2 are important for the swine industry. Among...
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Phenotypic and Functional Analysis of HL-60 Cells Used in Opsonophagocytic-Killing Assay for Streptococcus pneumoniae

Kim KH, Seoh JY, Cho SJ

Differentiated HL-60 is an effector cell widely used for the opsonophagocytic-killing assay (OPKA) to measure efficacy of pneumococcal vaccines. We investigated the correlation between phenotypic expression of immunoreceptors and phagocytic...
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Detection of Rotavirus Genotypes in Korea 5 Years after the Introduction of Rotavirus Vaccines

Chung JY, Kim MS, Jung TW, Kim SJ, Kang JH, Han SB, Kim SY, Rhim JW, Kim HM, Park JH, Jo DS, Ma SH, Jeong HS, Cheon DS, Kim JH

Rotavirus (RV) is one of the most important viral etiologic agents of acute gastroenteritis (AGE) in children. Although effective RV vaccines (RVVs) are now used worldwide, novel genotypes and outbreaks...
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New Molecules in Babesia gibsoni and Their Application for Diagnosis, Vaccine Development, and Drug Discovery

Goo YK, Xuan X

Babesia gibsoni is an intraerythrocytic apicomplexan parasite that causes piroplasmosis in dogs. B. gibsoni infection is characterized clinically by fever, regenerative anemia, splenomegaly, and sometimes death. Since no vaccine is...
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Recent progress in mucosal immunology and vaccine development

Kweon MN

No abstract available.
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Positive effects of porcine IL-2 and IL-4 on virus-specific immune responses induced by the porcine reproductive and respiratory syndrome virus (PRRSV) ORF5 DNA vaccine in swine

Tang D, Liu J, Li C, Zhang H, Ma P, Luo X, Zeng Z, Hong N, Liu X, Wang B, Wang F, Gan Z, Hao F

The purpose of this study was to investigate the effects of porcine interleukin (IL)-2 and IL-4 genes on enhancing the immunogenicity of a porcine reproductive and respiratory syndrome virus ORF5...
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Induction of antibody and interferon-gamma production in mice immunized with virus-like particles of swine hepatitis E virus

Song YJ, Park WJ, Lee SK, Lee JB, Park SY, Song CS, Lee SW, Seo KH, Kang YS, Song JY, Choi IS

Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers...
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Current State of Influenza Vaccination and Factors Affecting Vaccination Rate among Pregnant Women

Kim OS, Yoon SW

PURPOSE: This study was done to examine the actual state of influenza vaccination among pregnant women and factors affecting vaccination rate. METHODS: Data were collected using self-report questionnaires. Participants were pregnant...
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Cross-Protective Immune Responses Elicited by Live Attenuated Influenza Vaccines

Jang YH, Seong BL

The desired effect of vaccination is to elicit protective immune responses against infection with pathogenic agents. An inactivated influenza vaccine is able to induce the neutralizing antibodies directed primarily against...
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Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine

Yan F, Zhao Y, Hu Y, Qiu J, Lei W, Ji W, Li X, Wu Q, Shi X, Li Z

The protective efficacy of DNA plasmids encoding avian infectious bronchitis virus (IBV) S1, N, or M protein was investigated in chickens. Chickens were inoculated monovalently (with plasmid pVAX1-16S1, pVAX1-16M, or...
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