J Vet Sci.  2002 Dec;3(4):315-319.

Host Immune Responses Against Hog Cholera Virus in Pigs Treated with an Ionized Alkali Mineral Complex

• Park BK
• Lyoo KS
• Park YH
• Koh JH
• Seo KS

Abstract

To determine the immune responses in pigs to hog cholera virus after treatment with an ionized alkali mineral complex (IAMC), 40 healthy pigs (28-32 days old) from a commercial swine farm were purchased and housed into 4 groups (n=10 each). All pigs were vaccinated intramuscularly (1 ml) with an attenuated live hog cholera virus (HCV, LOM strain) at 28-32 days old and challenged with a virulent hog cholera virus at 8 weeks after vaccination. Each group was treated with PowerFeelTM sprayed diet as 0.05% (w/w) in a final concentration (T-1, n=10), a diet mixed with SuperFeedTM as 3% (w/w) in a final concentration (T-2, n=10), or a diluted PowerFeelTM solution (1:500, v/v) as drinking water (T-3, n=10), respectively. A group (n=10) served as a non-treated control. Proportions of expressing CD2+ and CD8+ cells increased significantly (p<, 0.05) at 8-week post-application. Mean antibody titers of each group against HCV gradually increased to higher levels after vaccination and with challenge of the virulent virus. In conclusion, the IAMC-treated diets can be helpful for the improvement of growth in pigs with proper vaccination program, while the IAMC-treated diets have no effects on the clinical protection against hog cholera.

Keyword

Ionized alkali mineral complex; Hog cholera virus; Porcine immune cells

MeSH Terms

Alkalies/immunology/*pharmacology
Animals
Antibodies, Viral/blood
Classical Swine Fever/*immunology/prevention & control
Classical swine fever virus/*immunology
Flow Cytometry/veterinary
Fluorescent Antibody Technique, Indirect/veterinary
HLA Antigens/immunology
Minerals/immunology/*pharmacology
Swine
Vaccination/*veterinary
Vaccines, Attenuated/immunology
Viral Vaccines/*immunology