J Vet Sci.  2016 Jun;17(2):253-256. 10.4142/jvs.2016.17.2.253.

Increased humoral antibody response of foot-and-mouth disease virus vaccine in growing pigs pre-treated with poly-γ-glutamic acid

Affiliations
  • 1Department of Veterinary Medicine Virology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea. parkx026@snu.ac.kr

Abstract

This study was conducted to determine if humoral antibody response of foot-and-mouth disease (FMD) vaccine improved in 8-week-old growing pigs born to well-vaccinated sows pre-treated with 60 mg of poly-γ-glutamic acid (γ-PGA) three days before vaccination. Antibody against FMD virus serotype O was measured 0, 2, 4 and 6 weeks post-vaccination, using a PrioCHECK FMDV type O ELISA kit. The results showed that positive antibody reactions against FMDV serotype O antigen among a component of the vaccine significantly increased in response to pre-injection with γ-PGA.

Keyword

foot-and-mouth disease virus vaccine; humoral immune response; poly-γ-glutamic acid

MeSH Terms

Animals
Antibodies, Viral/immunology
Foot-and-Mouth Disease/immunology/*prevention & control/virology
Foot-and-Mouth Disease Virus/*immunology
*Immunity, Humoral/drug effects
Immunologic Factors/administration & dosage/pharmacology
Polyglutamic Acid/administration & dosage/*analogs & derivatives/pharmacology
Swine
Swine Diseases/immunology/*prevention & control/virology
Vaccination/*veterinary
Viral Vaccines/*immunology
Antibodies, Viral
Immunologic Factors
Viral Vaccines
Polyglutamic Acid

Figure

  • Fig. 1 Comparative distribution of percentage inhibition (PI) values at 0, 2, 4 and 6 weeks after foot-and-mouth disease vaccination in 8-week-old pigs pre-injected with γ-PGA at 3 days before vaccination. con, control; tre, treatment.


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