Korean J Parasitol.  2014 Aug;52(4):345-353. 10.3347/kjp.2014.52.4.345.

New Molecules in Babesia gibsoni and Their Application for Diagnosis, Vaccine Development, and Drug Discovery

• Goo YK
• Xuan X

• KMID: 1792195
• DOI: http://doi.org/10.3347/kjp.2014.52.4.345

Abstract

Babesia gibsoni is an intraerythrocytic apicomplexan parasite that causes piroplasmosis in dogs. B. gibsoni infection is characterized clinically by fever, regenerative anemia, splenomegaly, and sometimes death. Since no vaccine is available, rapid and accurate diagnosis and prompt treatment of infected animals are required to control this disease. Over the past decade, several candidate molecules have been identified using biomolecular techniques in the authors' laboratory for the development of a serodiagnostic method, vaccine, and drug for B. gibsoni. This review article describes newly identified candidate molecules and their applications for diagnosis, vaccine production, and drug development of B. gibsoni.

Keyword

Babesia gibsoni; serodiagnosis; vaccine; drug

MeSH Terms

Animals
Antigens, Protozoan/*diagnostic use/*immunology
Antiprotozoal Agents/*isolation & purification/pharmacology
Babesia/*drug effects/immunology/*isolation & purification
Babesiosis/*diagnosis/drug therapy/prevention & control
Dogs
Drug Discovery/methods
Protozoan Vaccines/*immunology
Antigens, Protozoan
Antiprotozoal Agents
Protozoan Vaccines