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Treatment of Periodontal Bone Defects with Stem Cells from Inflammatory Dental Pulp Tissues in Miniature Swine

Li Y, Nan X, Zhong TY, Li T, Li A

BACKGROUND: Containing a certain proportion of mesenchymal stem cells, inflammatory dental tissue showed great tissue regeneration potential in recent years. However, whether it is applicable to promote tissue regeneration in...
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Surgically induced degenerative changes in the femorotibial joints by total medial meniscectomy in minipigs closely resemble late-stage osteoarthritis

Lee WJ, Park BJ, Lee HJ, Jang SJ, Lee SL, Lee JH, Rho GJ, Kim SJ

Animal models of osteoarthritis (OA) have played a key role in understanding the etiology of OA and in the development of new therapeutic strategies. Although pigs have an advantage as...
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Disagreement between direct and indirect blood pressure measurements obtained from minipigs

Lee WJ, Park LS

Blood pressure (BP) measurement plays a pivotal role in veterinary medicine for diagnosing cardiovascular disorders and monitoring anesthesia of animals. Although indirect BP measurement has been widely applied to monitor...
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Establishment and identification of cell lines from type O blood Korean native pigs and their efficiency in supporting embryonic development via somatic cell nuclear transfer

Taweechaipaisankul A, Kim GA, Jin JX, Yeom SC, Lee BC

Due to their similarities with humans in anatomy, physiology, and genetics miniature pigs are becoming an attractive model for biomedical research. We aim to establish and evaluate blood type O...
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Benefits of procyanidins on gut microbiota in Bama minipigs and implications in replacing antibiotics

Zhao T, Shen X, Dai C, Cui L

Several studies have reported the effect of absorption of procyanidins and their contribution to the small intestine. However, differences between dietary interventions of procyanidins and interventions via antibiotic feeding in...
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Structural Changes of the Urinary Bladder After Chronic Complete Spinal Cord Injury in Minipigs

Foditsch E, Roider K, Patras I, Hutu I, Bauer S, Janetschek G, Zimmermann R

PURPOSE: The aim of this study was to determine the structural changes of the urinary bladder after chronic spinal cord injury (SCI) in minipigs with the primary focus on the...
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Differential regulation of senescence and in vitro differentiation by 17β-estradiol between mesenchymal stem cells derived from male and female mini-pigs

Lee WJ, Lee SC, Lee JH, Rho GJ, Lee SL

The characterization and potential of mesenchymal stem cells (MSCs) are gender dependent and estrogen influences these properties. This study demonstrated that supplementation with 17β-estradiol (E2) increases the proliferation of bone...
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Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model

Kim J, Park S, Jeon BS, Jang WS, Lee SJ, Son Y, Rhim KJ, Lee SI, Lee SS

Curcumin protects the skin against radiation-induced epidermal damage and prevents morphological changes induced by irradiation skin, thereby maintaining the epidermal thickness and cell density of basal layers. In this study,...
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Intrapancreatic ectopic splenic tissue found in a cloned miniature pig

Koo OJ, Ha SK, Park SJ, Park HJ, Kim SJ, Kwon D, Kang JT, Moon JH, Park EJ, Jang G, Lee BC

Somatic cell nuclear transfer (SCNT) is a cost-effective technique for producing transgenic pigs. However, abnormalities in the cloned pigs might prevent use these animals for clinical applications or disease modeling....
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A Bama Minipig Model of Laryngopharyngeal Reflux and the Change of Laryngopharyngeal Mucosal Ultrastructure

Feng G, Zhang Z, Diao C, Jiang J, Zheng S, Liu Y

  • KMID: 2381250
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):182-188.
  • doi: 10.5056/jnm14113
BACKGROUND/AIMS: To establish an animal model of laryngopharyngeal reflux (LPR) and study the effect of LPR on the laryngopharyngeal mucosal ultrastructure. METHODS: Ten Bama minipigs were randomly divided into control group...
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beta-irradiation (166Ho patch)-induced skin injury in mini-pigs: effects on NF-kappaB and COX-2 expression in the skin

Kim JS, Rhim KJ, Jang WS, Lee SJ, Son Y, Lee SS, Park S, Lim SM

In the present study, the detrimental effect of beta-emission on pig skin was evaluated. Skin injury was modeled in mini-pigs by exposing the animals to 50 and 100 Gy of...
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Effect on bone formation of the autogenous tooth graft in the treatment of peri-implant vertical bone defects in the minip

Kim SK, Kim SW, Kim KW

BACKGROUND: The aim of this study was to evaluate the effect of autogenous tooth bone as a graft material for regeneration of bone in vertical bony defects of the minipigs. MATERIAL...
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Laparoscopic left hepatectomy in swine: a safe and feasible technique

Zhang H, Liu T, Wang Y, Liu HF, Zhang JT, Wu YS, Lei L, Wang HB

A purely laparoscopic four-port approach was created for left hepatectomy in pigs. A polyethylene loop was placed on the left two hepatic lobes for traction and lift. Next, penetrating ligation...
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Development of osteoporosis animal model using micropigs

Kim SW, Kim KS, Solis CD, Lee MS, Hyun BH

  • KMID: 2312111
  • Lab Anim Res.
  • 2013 Sep;29(3):174-177.
Osteoporosis is a known major health problem and a serious disease of the bone, there has been a great need to develop more and newer animal models for this disease....
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Porcine study on the efficacy of autogenous tooth bone in the maxillary sinus

Lee DH, Yang KY, Lee JK

OBJECTIVES: This study sought to elucidate the effect of autogenous tooth bone material by experimenting on minipig's maxillary sinus and performing histological and histomorphometric analyses. MATERIALS AND METHODS: Five 18-24 month-old...
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Contrast-enhanced ultrasound analysis of renal perfusion in normal micropigs

Yi K, Ji S, Kim J, Yoon J, Choi M

Contrast-enhanced ultrasound is one of method for evaluating renal perfusion. The purpose of this project was to assess perfusion patterns and dynamics in normal micropig kidney using ultrasonographic contrast media....
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The Performance of Multiple Transgastric Procedures Using the Natural Orifice Transluminal Endoscopic Surgery Technique: Is Pure NOTES Satisfactory?

Song TJ, Seo DW, Kim SH, Park DH, Lee SS, Lee SK, Kim MH

  • KMID: 2167416
  • Gut Liver.
  • 2012 Oct;6(4):457-463.
BACKGROUND/AIMS: Although several groups have demonstrated the usefulness of natural orifice transluminal endoscopic surgery (NOTES), there is still concern about frequent serious adverse events. We performed this study to determine...
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Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation

Ryu JM, Yoon W, Park JH, Yun SP, Jang MW, Han HJ

Due primarily to the increasing shortage of allogeneic donor organs, xenotransplantation has become the focus of a growing field of research. Currently, micropigs are the most suitable donor animal for...
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Computed tomographic evaluation of abdominal fat in minipigs

Chang J, Jung J, Lee H, Chang D, Yoon J, Choi M

Computed tomography (CT) exams were conducted to determine the distribution of abdominal fat identified based on the CT number measured in Hounsfield Units (HU) and to measure the volume of...
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Magnetic resonance imaging evaluation of Yukatan minipig brains for neurotherapy applications

Yun SP, Kim DH, Ryu JM, Park JH, Park SS, Jeon JH, Seo BN, Kim HJ, Park JG, Cho KO, Han HJ

Magnetic resonance imaging (MRI) of six Yukatan minipig brains was performed. The animals were placed in stereotaxic conditions currently used in experiments. To allow for correctpositioning of the animal in...
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