J Vet Sci.  2007 Sep;8(3):223-227. 10.4142/jvs.2007.8.3.223.

Effectiveness of 99mTc-tetrofosmin for assessment of heart functions in micropigs

• Lee MY
• Lee SH
• Park JH
• Heo JS
• Lee YJ
• Suh HN
• Min JJ
• Seo YS
• Han HJ

• KMID: 1090795
• DOI: http://doi.org/10.4142/jvs.2007.8.3.223

Abstract

This study examined the suitability of a nuclear imagingtechnique using 99mTc-tetrofosmin as an agent to assess theheart functions of healthy micropigs. The mean age of thepigs was 360 days (male), and the mean body weight was35.3kg ranging from 34.5-36kg. There were no significantperfusion defects in any of the reconstructed images.Gated single-photon emission computed tomographyimaging can be used to calculate the ventricular volumeand ejection fraction (EF). In this case, an EF of 79% wascalculated from the ventricular volume of the end-systolicimage (10 ml) subtracted from that of the end-diastolicvolume (49 ml). A perfusion defect (particularly the apex,lateral wall) is unlikely because of the presence of apreserved wall motion in a segment with a defect. It isconcluded that quantitative cardiac scintigraphy, using99mTc-tetrofosmin is an adequate technique for estimatingthe heart functions of healthy micropigs.

Keyword

ejection fraction (EF); heart function; micropig; 99mTc-tetrofosmin

MeSH Terms

Animals
Heart/*radionuclide imaging
Heart Function Tests/methods/*veterinary
Male
Organophosphorus Compounds/*diagnostic use
Organotechnetium Compounds/*diagnostic use
Swine
Swine, Miniature/*physiology
Tomography, Emission-Computed, Single-Photon/methods/*veterinary

Figure

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  Fig. 1 A micropig positioned ventro-dorsally, and restrained physically and pharmacologically for an assessment of the cardiac function using gated 99mTc-tetrofosmin single photon emission computed tomography.

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  Fig. 2 Cardiac perfusion images. A-C: These images showed myocardial perfusion (Yellow arrow: anterior wall, Yellow dotted arrow: septal wall, white arrow: inferior wall, white dotted arrow: lateral wall). Cardiac short-axis (A), vertical long-axis (B), horizontal long-axis (C) was represented. The polar map (D) an image showing quantified values of perfusion of each cardiac region as a map.

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  Fig. 3 These images represent the cardiac wall motion reconstructed as 3 dimensional image. The cardiac wall motion images showed a visualization of the radioactivity of 99mTc-tetrofosmin in the heart and cardiac perfusion volume. A: end-diastole volume B: end-systole volume.

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  Fig. 4 Images representing the quantitative wall motion and thickening that provides evidence of the ventricular function. A: thickening (above: end-diastolic image, below: end-systolic image), B: thickening map.

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