J Vet Sci.  2015 Jun;16(2):241-244. 10.4142/jvs.2015.16.2.241.

Intrapancreatic ectopic splenic tissue found in a cloned miniature pig

• Koo OJ
• Ha SK
• Park SJ
• Park HJ
• Kim SJ
• Kwon D
• Kang JT
• Moon JH
• Park EJ
• Jang G
• Lee BC

• KMID: 2164536
• DOI: http://doi.org/10.4142/jvs.2015.16.2.241

Abstract

Somatic cell nuclear transfer (SCNT) is a cost-effective technique for producing transgenic pigs. However, abnormalities in the cloned pigs might prevent use these animals for clinical applications or disease modeling. In the present study, we generated several cloned pigs. One of the pigs was found to have intrapancreatic ectopic splenic tissue during histopathology analysis although this animal was grossly normal and genetically identical to the other cloned pigs. Ectopic splenic tissue in the pancreas is very rare, especially in animals. To the best of our knowledge, this is the first such report for cloned pigs.

Keyword

cloned pig; intrapancreatic ectopic splenic tissue; somatic cell nuclear transfer

MeSH Terms

Animals
Animals, Genetically Modified
Choristoma/pathology/*veterinary
Cloning, Organism
Nuclear Transfer Techniques/*veterinary
*Pancreas
Splenic Diseases/pathology/*veterinary
Swine
Swine Diseases/*pathology
Swine, Miniature

Figure

• 

  Fig. 1 Ectopic splenic tissue in the pancreas of Clone 1. (A) The figure shows splenic tissue widely dispersed at the center of the section. (B) The boundary between the splenic tissue (right area) and pancreas (left area) was delineated by a fibrous capsule. H&E staining, 12.5× (A), 100× (B) magnification.

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