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Post-mortem re-cloning of a transgenic red fluorescent protein dog

Hong SG, Koo OJ, Oh HJ, Park JE, Kim M, Kim GA, Park EJ, Jang G, Lee BC

Recently, the world's first transgenic dogs were produced by somatic cell nuclear transfer. However, cellular senescence is a major limiting factor for producing more advanced transgenic dogs. To overcome this...
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Intrapancreatic ectopic splenic tissue found in a cloned miniature pig

Koo OJ, Ha SK, Park SJ, Park HJ, Kim SJ, Kwon D, Kang JT, Moon JH, Park EJ, Jang G, Lee BC

Somatic cell nuclear transfer (SCNT) is a cost-effective technique for producing transgenic pigs. However, abnormalities in the cloned pigs might prevent use these animals for clinical applications or disease modeling....
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Quercetin improves the in vitro development of porcine oocytes by decreasing reactive oxygen species levels

Kang JT, Kwon DK, Park SJ, Kim SJ, Moon JH, Koo OJ, Jang G, Lee BC

Quercetin is a plant-derived flavonoid found in fruits or vegetables that has antioxidant properties and acts as a free radical scavenger. We investigated the effects of quercetin on porcine oocyte...
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in vivo multiplex gene targeting with Streptococcus pyogens and Campylobacter jejuni Cas9 for pancreatic cancer modeling in wildtype animal

Chang YJ, Bae J, Zhao Y, Lee G, Han J, Lee YH, Koo OJ, Seo S, Choi YK, Yeom SC

Pancreatic ductal adenocarcinoma is a lethal cancer type that is associated with multiple gene mutations in somatic cells. Genetically engineered mouse is hardly applicable for developing a pancreatic cancer model,...
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Functional improvement of porcine neonatal pancreatic cell clusters via conformal encapsulation using an air-driven encapsulator

Park SJ, Shin S, Koo OJ, Moon JH, Jang G, Ahn C, Lee BC, Yoo YJ

Transplantation of islet cells into diabetic patients is a promising therapy, provided that the islet cells are able to evade host immune rejection. With improved islet viability, this strategy may...
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