J Vet Sci.  2010 Sep;11(3):185-189. 10.4142/jvs.2010.11.3.185.

64-Channel multi-detector row CT angiographic evaluation of the micropigs for potential living donor lung transplantation

• Yoon W
• Ryu JM
• Lee MY
• Moon YJ
• Lee SH
• Park JH
• Yun SP
• Jang MW
• Park SS
• Han HJ

• KMID: 1093491
• DOI: http://doi.org/10.4142/jvs.2010.11.3.185

Abstract

Micropigs are the most likely source animals for xenotransplantation. However, an appropriate method for evaluating the lung of micropigs had not been established. Therefore, this study was performed to evaluate the feasibility of 64-channel multi-detector row computed tomography (MDCT) to measure the diameter of the pulmonary arteries and the lung volume in micropigs. The mean diameters of the trachea, and left and right bronchi were 1.6 +/- 0.17, 1.18 +/- 0.14, and 1.1 +/- 0.11 cm, respectively. The mean diameters of the main, right, and left pulmonary arteries were 1.38 +/- 0.09, 1.07 +/- 0.26, and 0.98 +/- 0.13 cm and the diameters of right, left, and common inferior pulmonary veins were 0.97 +/- 0.20, 0.76 +/- 0.20, and 1.99 +/- 0.26 cm, respectively. The mean lung volume was 820.3 +/- 77.11 mL. The data presented in this study suggest that the MDCT may be a noninvasive, rapid, and accurate investigational method for pulmonary anatomy in living lung donors.

Keyword

lung; micropig; multidetector row computed tomography (MDCT)

MeSH Terms

Animals
Humans
Lung/physiology/*radiography
Organ Size/physiology
Pulmonary Artery/physiology/*radiography
Swine
Swine, Miniature/*anatomy & histology
Tomography, X-Ray Computed/*methods
Transplantation, Heterologous/*methods

Figure

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  Fig. 1 (A) Three-dimensional external rendered image of the central airways in a normal micropig. (B) Coronal two-dimensional multiplanar reformatted image of a micropig reveals a tracheal bronchus (arrow) arising from the right lateral wall of the trachea and aerating the upper lobe of the right lung.

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  Fig. 2 3D-CTA image showing normal pulmonary vascular anatomy. Posteroanterior, 3-dimensional volume rendering image shows major pulmonary vessels in a normal micropig. Ao: aorta, MPA: main pulmonary artery, RPA: right pulmonary artery, LPA: left pulmonary artery. CIPV: common inferior pulmonary vein.

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  Fig. 3 3D-CTA image showing the anatomy of pulomonary veins in a micropig. Posteroanterior view of a 3-dimensional volume rendering image shows separate superior pulmonary veins (S) and a common inferior pulmonary vein (C) draining both right and left inferior pulmonary veins (I).

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