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Prediction of Cancer Incidence and Mortality in Korea, 2025

Jung KW, Kang MJ, Park EH, Yun EH, Kim HJ, Kim JE, Kong HJ, Choi KS, Yang HK

Purpose This study aimed to project cancer incidence and mortality for 2025 to estimate Korea’s current cancer burden. Materials and Methods Cancer incidence data from 1999 to 2022 were obtained from...
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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2022

Park EH, Jung KW, Park NJ, Kang MJ, Yun EH, Kim HJ, Kim JE, Kong HJ, Choi KS, Yang HK, The Community of Population-Based Regional Cancer Registries

Purpose The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2022, with international comparisons. Materials and Methods Cancer incidence, survival,...
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Is Colonoscopy Alone Adequate for Surveillance in Stage I Colorectal Cancer?

Kim S, Shin JK, Park Y, Huh JW, Kim HC, Yun SH, Lee WY, Cho YB

Purpose While colonoscopy is the standard surveillance tool for stage I colorectal cancer according to National Comprehensive Cancer Network guidelines, its effectiveness in detecting recurrence is debated. This study evaluates...
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The Era of Antibody Drug Conjugates in Lung Cancer: Trick or Threat?

Riudavets M, Planchard D

Antibody drug conjugates (ADCs) are a novel class of therapeutics that structurally are composed by an antibody directed to a tumor epitope connected via a linker to a cytotoxic payload,...
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Association of Shorter Time to Recurrence and Recurrence-Free Survival with Transthoracic Lung Biopsy in Stage I Lung Cancer

Chae KJ, Hong H, Park H, Yoon SH

Purpose We aim to determine whether preoperative percutaneous needle aspiration or biopsy (PCNA/Bx) increases recurrence risk and reduces survival in stage I lung cancer patients, using a nationwide lung cancer...
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Weight Change after Cancer Diagnosis and Risk of Diabetes Mellitus: A Population-Based Nationwide Study

Koo HY, Han K, Cho MH, Jung W, Jung J, Cho IY, Shin DW

Purpose Cancer survivors are at increased risk of diabetes mellitus (DM). Additionally, the prevalence of obesity, which is also a risk factor for DM, is increasing in cancer survivors. We...
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Target-Enhanced Whole-Genome Sequencing Shows Clinical Validity Equivalent to Commercially Available Targeted Oncology Panel

Lee S, Roh J, Park JS, Tuncay IO, Lee W, Kim JA, Oh BBL, Shin JY, Lee JS, Ju YS, Kim R, Park S, Koo J, Park H, Lim J, Connolly-Strong E, Kim TH, Choi YW, Ahn MS, Lee HW, Kim S, Kim JH, Kwon M

Purpose Cancer poses a significant global health challenge, demanding precise genomic testing for individualized treatment strategies. Targeted-panel sequencing (TPS) has improved personalized oncology but often lacks comprehensive coverage of crucial...
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Determinants of Prostate Cancer Screening in Korean Men: A Nationwide Study Using the Korean National Cancer Screening Survey 2023

Nguyen GV, Lee K, Lee HJ, Kang E, Suh M, Jun JK, Choi KS

Purpose Research on the prevalence of prostate cancer (PCa) screening and reasons for undergoing screening is limited. We aimed to identify the factors influencing PCa screening behavior and explore the...
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Combination Therapy of Pyrotinib and Metronomic Vinorelbine in HER2+ Advanced Breast Cancer after Trastuzumab Failure (PROVE): A Prospective Phase 2 Study

Hao C, Wang X, Shi Y, Tong Z, Li S, Liu X, Zhang L, Zhang J, Meng W, Zhang L

Purpose Approximately 50%-74% of patients with metastatic human epidermal growth factor receptor 2 (HER2)–positive breast cancer do not respond to trastuzumab, with 75% of treated patients experiencing disease progression within...
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Kinect-Based Mixed Reality Exercise Program Improves Physical Function and Quality of Life in Breast Cancer Survivors: A Randomized Clinical Trial

Lim B, Li X, Sung Y, Jamrasi P, Ahn S, Shin H, Song W

Purpose Exercise is an effective non-pharmacological approach for alleviating treatment-related adverse effects and enhancing physical fitness in breast cancer survivors. A Kinect-based mixed reality device (KMR), with real-time feedback and...
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Long-term Clinical Efficacy of Radiotherapy for Patients with Stage I-II Gastric Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue: A Retrospective Multi-institutional Study

Jeong JU, Lee HC, Song JH, Eom KY, Kim JH, Kwak YK, Kim WC, Lee SY, Choi JH, Lee KK, Lee JH

Purpose This study aimed to evaluate long-term treatment outcomes in patients with localized gastric mucosa-associated lymphoid tissue (MALT) lymphoma treated with radiotherapy (RT). Materials and Methods A total of 229 patients...
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Harnessing Institutionally Developed Clinical Targeted Sequencing to Improve Patient Survival in Breast Cancer: A Seven-Year Experience

Koh J, Kim J, Woo GU, Yi H, Kwon SY, Seo J, Bae JM, Kim JH, Won JK, Ryu HS, Jeon YK, Lee DW, Kim M, Kim TY, Lee KH, Kim TY, Lee JS, Seong MW, Kim S, Lee S, Yun H, Song MG, Choi J, Kim JI, Im SA

Purpose Considering the high disease burden and unique features of Asian patients with breast cancer (BC), it is essential to have a comprehensive view of genetic characteristics in this population....
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Impact of TTF-1 Expression on the Prognostic Prediction of Patients with Non–Small Cell Lung Cancer with PD-L1 Expression Levels of 1% to 49%, Treated with Chemotherapy vs. Chemoimmunotherapy: A Multicenter, Retrospective Study

Nishioka N, Hata T, Yamada T, Goto Y, Amano A, Negi Y, Watanabe S, Furuya N, Oba T, Ikoma T, Nakao A, Tanimura K, Taniguchi H, Yoshimura A, Fukui T, Murata D, Kaira K, Shiotsu S, Hibino M, Okada A, Chihara Y, Kawachi H, Kijima T, Takayama K

Purpose Thyroid transcription factor 1 (TTF-1) expression is a useful predictor of treatment efficacy in advanced non-squamous non–small cell lung cancer (NSCLC). This study aimed to evaluate whether TTF-1 could...
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Unraveling the Impact of Sarcopenia-Induced Lymphopenia on Treatment Response and Prognosis in Patients with Stage III Non–Small Cell Lung Cancer: Insights for Optimizing Chemoradiation and Immune Checkpoint Inhibitor

Lee J, Kim KH, Kim J, Lee CG, Cho J, Yoon HI, Cho Y

Purpose Sarcopenia is a poor prognostic factor in non–small cell lung cancer (NSCLC). However, its prognostic significance in patients with NSCLC receiving immune checkpoint inhibitors (ICIs) and its relationship with...
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Second-Line Fluoropyrimidine-Based Chemotherapy in Advanced Biliary Tract Cancer: A Meta-analysis Based on Individual Patient-Level Data of Randomized Trials

Hyung J, Kang M, Kim I, Kim Kp, Ryoo BY, Cheon J, Ryu H, Lee JS, Kim JW, Choi IS, Park JH, Abou-Alfa GK, Kim JW, Yoo C

Purpose While fluoropyrimidine-based chemotherapy regimens are recommended second-line treatment for patients with advanced biliary tract cancer (BTC), there have been no studies comparing different regimens head-to-head. Materials and Methods We performed individual...
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Histological Assessment and Interobserver Agreement in Major Pathologic Response for Non–Small Cell Lung Cancer with Neoadjuvant Therapy

Kim S, Lee J, Chung JH

Purpose Major pathologic response (MPR), defined as ≤ 10% of residual viable tumor (VT), is a prognostic factor in non–small cell lung cancer (NSCLC) after neoadjuvant therapy. This study evaluated...
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Survival of Children with Acute Lymphoblastic Leukemia with Risk Group–Based Protocol Changes: A Single-Center Experience with 460 Patients over a 20-Year Period

Lee NH, Ju HY, Yi ES, Choi YB, Yoo KH, Koo HH

Purpose Recent treatments for pediatric acute lymphoblastic leukemia (ALL) are founded on risk stratification. We examined the survival rates and prognostic factors of patients over a 20-year period at a...
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Association between Tumor Size at the Time of Disease Progression and Survival Outcomes

Maeng CH, Kim BJ, Ahn MJ, Choi IS, Zang DY, Kim BH, Kwon M, Heo DS, Keam B

Purpose This study evaluates the prognostic significance of tumor size at disease progression (PD) and depth of response (DOR) in cancer patients. Materials and Methods We performed post hoc analysis using data from...
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Synergistic Activation of LEPR and ADRB2 Induced by Leptin Enhances Reactive Oxygen Specie Generation in Triple-Negative Breast Cancer Cells

Liu C, Yu J, Du Y, Xie Y, Song X, Liu C, Yan Y, Wang Y, Qin J

Purpose Leptin interacts not only with leptin receptor (LEPR) but also engages with other receptors. While the pro-oncogenic effects of the adrenergic receptor β2 (ADRB2) are well-established, the role of...
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Application of Machine Learning Algorithms for Risk Stratification and Efficacy Evaluation in Cervical Cancer Screening among the ASCUS/LSIL Population: Evidence from the Korean HPV Cohort Study

Song H, Lee HY, Oh SA, Seong J, Hur SY, Choi YJ

Purpose We assessed human papillomavirus (HPV) genotype-based risk stratification and the efficacy of cytology testing for cervical cancer screening in patients with atypical squamous cells of undetermined significance (ASCUS)/low-grade squamous...
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