- Fabrication and Characterization of Polyphosphazene/Calcium Phosphate Scaffolds Containing Chitosan Microspheres for Sustained Release of Bone Morphogenetic Protein 2 in Bone Tissue Engineering
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Sobhani A, Rafienia M, Ahmadian M, Naimi-Jamal MR
- KMID: 2394987
- Tissue Eng Regen Med.
- 2017 Oct;14(5):525-538.
- doi: 10.1007/s13770-017-0056-z
Bone morphogenetic protein 2 has a major role in promoting bone regeneration in tissue engineering scaffolds. Growth factor release rate is a remaining crucial problem in these systems. The aim... -
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- Effect of combinatorial bone morphogenetic protein 2 and bone morphogenetic protein 7 gene delivery on osteoblastic differentiation
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Bae Y, Kim KH, Kim SH, Lee CW, Koo KT, Kim TI, Seol YJ, Ku Y, Rhyu IC, Chung CP, Lee YM
- KMID: 2321654
- J Korean Acad Periodontol.
- 2009 Aug;39(Suppl):279-286.
PURPOSE: Gene therapy (ex vivo) has recently been used as a means of delivering bone morphogenetic proteins (BMPs) to sites of tissue regeneration. In the present study, we investigated the... -
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- Bone Morphogenetic Protein Receptor in the Osteogenic Differentiation of Rat Bone Marrow Stromal Cells
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Wang A, Ding X, Sheng S, Yao Z
- KMID: 1071427
- Yonsei Med J.
- 2010 Sep;51(5):740-745.
- doi: 10.3349/ymj.2010.51.5.740
PURPOSE: Several signaling pathways have been shown to regulate the lineage commitment and terminal differentiation of bone marrow stromal cells (BMSCs). Bone morphogenetic protein (BMP) signaling has important effects on... -
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- Comparative analysis of carrier systems for delivering bone morphogenetic proteins
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Jung IH, Lim HC, Lee EU, Lee JS, Jung UW, Choi SH
- KMID: 2164342
- J Periodontal Implant Sci.
- 2015 Aug;45(4):136-144.
- doi: 10.5051/jpis.2015.45.4.136
PURPOSE: The objective of this study was to comparatively assess the bone regenerative capacity of absorbable collagen sponge (ACS), biphasic calcium phosphate block (BCP) and collagenated biphasic calcium phosphate (CBCP)... -
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- Evaluation of bone formation by recombinant human BMP-2 and rapid prototype titanium cap in rabbit calvaria using micro computed tomography
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Han MS, Jung S, Kim BS, Yang JW, Kook MS, Park HJ, Ryu SY, Oh HK
- KMID: 2328583
- J Korean Assoc Oral Maxillofac Surg.
- 2010 Dec;36(6):466-472.
INTRODUCTION: This study examined the effect of recombinant human bone morphogenetic protein (rhBMP)-2 and beta-tricalcium phosphate (beta-TCP) on new bone formation in a rabbit calvarium using a rapid prototype titanium... -
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- Angiogenesis and Mineralization During Distraction Osteogenesis
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Choi IH, Chung CY, Cho TJ, Yoo WJ
- KMID: 1109748
- J Korean Med Sci.
- 2002 Aug;17(4):435-447.
- doi: 10.3346/jkms.2002.17.4.435
Distraction osteogenesis is currently a standard method of bone lengthening. It is a viable method for the treatment of short extremities as well as extensive bone defects, because large amounts... -
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- The Effect of Platelet Rich Plasma from Bone Marrow Aspirate with Added Bone Morphogenetic Protein-2 on the Achilles Tendon-Bone Junction in Rabbits
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Kim HJ, Nam HW, Hur CY, Park M, Yang HS, Kim BS, Park JH
- KMID: 1097171
- Clin Orthop Surg.
- 2011 Dec;3(4):325-331.
- doi: 10.4055/cios.2011.3.4.325
BACKGROUND: To determine if exogenously injected bone marrow derived platelet-rich plasma (PRP) plus bone morphogenetic protein (BMP)-2 could accelerate the healing of bone-tendon junction injuries and increase the junction holding... -
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- Bone formation around rhBMP-2-coated implants in rabbit sinuses with or without absorbable collagen sponge grafting
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Baek WS, Yoon SR, Lim HC, Lee JS, Choi SH, Jung UW
- KMID: 2354942
- J Periodontal Implant Sci.
- 2015 Dec;45(6):238-246.
- doi: 10.5051/jpis.2015.45.6.238
PURPOSE: The purpose of this study was to evaluate bone formation around recombinant human bone morphogenetic protein (rhBMP-2)-coated implants placed with or without absorbable collagen sponge (ACS) in rabbit maxillary... -
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- Bone Morphogenetic Protein 2-Conjugated Silica Particles Enhanced Early Osteogenic Differentiation of Adipose Stem Cells on the Polycaprolactone Scaffold
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Kim KJ, Choi MS, Shim JH, Rhie JW
- KMID: 2455048
- Tissue Eng Regen Med.
- 2019 Aug;16(4):395-403.
- doi: 10.1007/s13770-019-00195-x
BACKGROUND: Silica particles (SPs) induce cell proliferation and osteogenic differentiation. We reported that SPs in the scaffold induced early stage osteogenic differentiation. METHODS: A polycaprolactone (PCL) scaffold was fabricated with a... -
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- Improvement of the osteogenic potential of ErhBMP-2-/EGCG-coated biphasic calcium phosphate bone substitute: in vitro and in vivo activity
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Hwang JH, Oh S, Kim S
- KMID: 2444223
- J Periodontal Implant Sci.
- 2019 Apr;49(2):114-126.
- doi: 10.5051/jpis.2019.49.2.114
PURPOSE: The aim of this study was to evaluate the enhancement of osteogenic potential of biphasic calcium phosphate (BCP) bone substitute coated with Escherichia coli-derived recombinant human bone morphogenetic protein-2... -
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- Combined effect of bisphosphonate and recombinant human bone morphogenetic protein 2 on bone healing of rat calvarial defects
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Kim HC, Song JM, Kim CJ, Yoon SY, Kim IR, Park BS, Shin SH
- KMID: 2381926
- Maxillofac Plast Reconstr Surg.
- 2015 Jun;37(6):16.
- doi: 10.1186/s40902-015-0015-3
PURPOSE: This study aimed to investigate new bone formation using recombinant human bone morphogenetic protein 2 (rhBMP-2) and locally applied bisphosphonate in rat calvarial defects. METHODS: Thirty-six rats were studied. Two... -
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- Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with two concentrations of expressed recombinant human bone morphogenetic protein 2
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Choi H, Park NJ, Jamiyandorj O, Choi KH, Hong MH, Oh S, Park YB, Kim S
- KMID: 1783647
- J Periodontal Implant Sci.
- 2012 Aug;42(4):119-126.
- doi: 10.5051/jpis.2012.42.4.119
PURPOSE: The aim of this study was to determine whether biphasic calcium phosphate (BCP) bone substitute with two different concentrations of Escherichia coli-expressed recombinant human bone morphogenetic protein 2 (ErhBMP-2)... -
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- Effects of rhBMP-2 with various carriers on bone regeneration in rat calvarial defect
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Lee SK, Kim JS, Kang EJ, Eum TK, Kim CS, Cho KS, Chai JK, Kim CK, Choi SH
- KMID: 1486794
- J Korean Acad Periodontol.
- 2008 Jun;38(2):125-134.
- doi: 10.5051/jkape.2008.38.2.125
PURPOSE: Bone morphogenetic protein (BMP) is a potent differentiating agent for cells of the osteoblastic lineage. It has been used in the oral cavity under a variety of indications and... -
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- Combined effect of recombinant human bone morphogenetic protein-2 and low level laser irradiation on bisphosphonate-treated osteoblasts
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Jeong SY, Hong JU, Song JM, Kim IR, Park BS, Kim CH, Shin SH
- KMID: 2467172
- J Korean Assoc Oral Maxillofac Surg.
- 2018 Dec;44(6):259-268.
- doi: 10.5125/jkaoms.2018.44.6.259
OBJECTIVES: The purpose of this study was to evaluate the synergic effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) and low-level laser therapy (LLLT) on bisphosphonate-treated osteoblasts. MATERIALS AND METHODS: Human... -
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- Bone Healing Properties of Autoclaved Autogenous Bone Grafts Incorporating Recombinant Human Bone Morphogenetic Protein-2 and Comparison of Two Delivery Systems in a Segmental Rabbit Radius Defect
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Choi EJ, Kang SH, Kwon HJ, Cho SW, Kim HJ
- KMID: 1910869
- Maxillofac Plast Reconstr Surg.
- 2014 May;36(3):94-102.
PURPOSE: This study aims to validate the effect of autoclaved autogenous bone (AAB), incorporating Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2), on critical-sized, segmental radius defects in rabbits. Delivery... -
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- Effect of immobilization of the recombinant human bone morphogenetic protein 2 (rhBMP-2) on anodized implants coated with heparin for improving alveolar ridge augmentation in beagle dogs: Radiographic observations
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Lee SH, Jo JY, Yun MJ, Jeon YC, Huh JB, Jeong CM
- KMID: 2000155
- J Korean Acad Prosthodont.
- 2013 Oct;51(4):307-314.
- doi: 10.4047/jkap.2013.51.4.307
PURPOSE: The aim of this study was to evaluate the effect of immobilization of the recombinant human bone morphogenetic protein 2 (rhBMP-2) on anodized titaum implants coated with heparin to... -
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- Comparison between heparin-conjugated fibrin and collagen sponge as bone morphogenetic protein-2 carriers for bone regeneration
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Yang HS, La WG, Cho YM, Shin W, Yeo GD, Kim BS
- KMID: 1383796
- Exp Mol Med.
- 2012 May;44(5):350-355.
Bone morphogenetic protein-2 (BMP-2) is used to promote bone regeneration. However, the bone regeneration ability of BMP-2 relies heavily on the delivery vehicle. Previously, we have developed heparin-conjugated fibrin (HCF),... -
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- A Novel Osteogenic Activity of Suberoylanilide Hydroxamic Acid is Synergized by BMP-2
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Lee ZH, Kim HJ, Ryoo HM
- KMID: 2170088
- J Bone Metab.
- 2015 May;22(2):51-56.
- doi: 10.11005/jbm.2015.22.2.51
BACKGROUND: Many histone deacetylase (HDAC) inhibitors are well recognized as potential anti-cancer drugs. Inhibition of HDACs induces temporal transcription or epigenetic control, thus regulating many different biological responses. Here, we... -
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- Eight-week healing of grafted calvarial bone defects with hyperbaric oxygen therapy in rats
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Oh SE, Hu KS, Kim S
- KMID: 2455800
- J Periodontal Implant Sci.
- 2019 Aug;49(4):228-236.
- doi: 10.5051/jpis.2019.49.4.228
PURPOSE: The purpose of this study was to evaluate the synergistic effect of adjunctive hyperbaric oxygen (HBO) therapy on new bone formation and angiogenesis after 8 weeks of healing. METHODS: Sprague-Dawley... -
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- Effects of Scytosiphon lomentaria on osteoblastic proliferation and differentiation of MC3T3-E1 cells
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Park MH, Kim S, Cheon J, Lee J, Kim BK, Lee SH, Kong C, Kim YY, Kim M
- KMID: 2313911
- Nutr Res Pract.
- 2016 Apr;10(2):148-153.
- doi: 10.4162/nrp.2016.10.2.148
BACKGROUND/OBJECTIVES: Bone formation and bone resorption continuously occur in bone tissue to prevent the accumulation of old bone, this being called bone remodeling. Osteoblasts especially play a crucial role in... -
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