J Korean Med Sci.  2002 Aug;17(4):435-447. 10.3346/jkms.2002.17.4.435.

Angiogenesis and Mineralization During Distraction Osteogenesis

• Choi IH
• Chung CY
• Cho TJ
• Yoo WJ

• KMID: 1109748
• DOI: http://doi.org/10.3346/jkms.2002.17.4.435

Abstract

Distraction osteogenesis is currently a standard method of bone lengthening. It is a viable method for the treatment of short extremities as well as extensive bone defects, because large amounts of bone can be regenerated in the distraction gap. echanical stimulation by distraction induces biological responses of skeletal regeneration that is accomplished by a cascade of biologic processes that may include differentiation of pluripotential tissue, angiogenesis, mineralization, and remodeling. There are complex interactions between bone-forming osteoblasts and other cells present within the bone microenvironment, particularly vascular endothelial cells that may be pivotal members of a complex interactive communication network in bone. Regenerate bone forms by three modes of ossification, which include intramembranous, enchondral, and transchondroid ossifications, although intramembraneous bone formation is the predominant mechanism of ossification. In this review we discussed the coupling between angiogenesis and mineralization, the biological and mechanical factors affecting them, the cellular and molecular events occurring during distraction osteogenesis, and the emerging modalities to accelerate regenerate bone healing and remodeling.

Keyword

Osteogenesis; Distraction; Neovascularization; Physiologic; Bone Mineralization

MeSH Terms

Animals
Biological Markers
Bone Morphogenetic Protein 2
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins/genetics/metabolism
Bone and Bones/radiography/ultrastructure
Calcification, Physiologic/*physiology
Collagen/metabolism
Cytokines/metabolism
Growth Substances/metabolism
Humans
Neovascularization, Physiologic/*physiology
Osteoblasts/physiology
*Osteogenesis, Distraction
*Transforming Growth Factor beta