Korean J Intern Med.  2018 Jul;33(4):649-659. 10.3904/kjim.2018.198.

Applications of kidney organoids derived from human pluripotent stem cells

Affiliations
  • 1Cell Death Disease Research Center, The Catholic University of Korea, Seoul, Korea.
  • 2Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. yangch@catholic.ac.kr
  • 3Convergent Research Consortium for Immunologic Disease, and Division of Nephrology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing of compounds, and regenerative therapy are attractive applications. Although much progress still remains to be made in the development of kidney organoids, recent advances in clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated system 9 (Cas9) genome editing and three-dimensional bioprinting technologies have contributed to the application of kidney organoids in clinical fields. In this section, we review recent advances in the applications of kidney organoids to kidney disease modelling, drug screening, nephrotoxicity testing, and regenerative therapy.

Keyword

Bioprinting; Clustered regularly interspaced short palindromic repeats; Kidney; Organoids; Transplantation

MeSH Terms

Bioprinting
Clustered Regularly Interspaced Short Palindromic Repeats
Drug Evaluation, Preclinical
Genome
Humans*
Kidney Diseases
Kidney*
Organoids*
Pluripotent Stem Cells*
Regenerative Medicine
Transplantation
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