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Cellular and genetic signatures of operational tolerance in kidney transplant recipients through single cell RNA sequencing analysis

Bae H, Lee H, Ryu JH, Jang JH, Lee J, Ko GY, Yang CW, Chung BH, Oh EJ

Background: Patients with operational tolerance do not use immunosuppressants after renal transplantation, but they show stable post-transplant results as stable patients with immunosuppressants. We analyzed differently expressed mRNAs and proteins...
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Intra-patient variability in tacrolimus trough levels over 2 years affects long-term allograft outcomes of kidney transplantation

Park Y, Lee H, Eum SH, Kim HD, Ko EJ, Yang CW, Chung BH

Background: The current study aimed to determine the impact of tacrolimus (TAC) trough level (C0) intra-patient variability (IPV) over 2 years after kidney transplantation (KT) on allograft outcomes. Methods: In total,...
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Changing patterns of T lymphocyte subsets after kidney transplantation according to induction immunosuppressant: single center prospective observational study

Kim HD, Bae H, Eum SH, Lee H, Ko EJ, Yang CW, Oh EJ, Chung BH

Background: The aim of this study is to investigate the changing patterns of T cell subsets during early post-transplant period according to the type of induction therapy (anti-thymocyte globulin [ATG]...
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Comparison of the impact between peak mean fluorescent intensity versus sum of mean fluorescent intensity value of donor specific anti-human leukocyte antigen antibody on the posttransplant clinical outcomes

Kim HD, Park Y, Eum SH, Lee H, Ko EJ, Yang CW, Chung BH

Background: In this study, we investigated to verify which of the peak value of donor-specific human leukocyte antigen antibodies (DSA) mean fluorescent intensity (MFI) and sum of MFI had higher...
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Water-soluble coenzyme Q10 provides better protection than lipid-soluble coenzyme Q10 in a rat model of chronic tacrolimus nephropathy

Cui S, Luo K, Quan Y, Lim SW, Shin YJ, Lee KE, Kim HL, Ko EJ, Kim JH, Chung SJ, Bae SK, Chung BH, Yang CW

Background/Aims: Coenzyme Q10 (CoQ10), is a promising antioxidant; however, low bioavailability owing to lipid-solubility is a limiting factor. We developed water-soluble CoQ10 (CoQ10-W) and compared its effects with conventional lipid-soluble...
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Impact of high body mass index on allograft outcomes in kidney transplant recipients with presensitization to human leukocyte antigen

Park Y, Lee H, Ko EJ, Lee S, Ban TH, Min JW, Yoon HE, Oh EJ, Yang CW, Chung BH

Background: This study aimed to investigate whether high body mass index (BMI) and presensitization to human leukocyte antigen (HLA) in kidney transplant recipients (KTRs) affected allograft outcomes. Methods: From January 2010...
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Impact of acute kidney injury in deceased donors with high Kidney Donor Profile Index on posttransplant clinical outcomes: a multicenter cohort study

Park WY, Chang YK, Kim YS, Jin K, Yang CW, Han S, Chung BH

Background: This study evaluated the impact of acute kidney injury (AKI) on posttransplant clinical outcomes for deceased donor (DD) kidney transplantation (KT) using the Kidney Donor Profile Index (KDPI) system....
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L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

Zhao HY, Li HY, Jin J, Jin JZ, Zhang LY, Xuan MY, Jin XM, Jiang YJ, Zheng HL, Jin YS, Jin YJ, Choi BS, Yang CW, Piao SG, Li C

Background/Aims: Accumulating evidence indicates that L-carnitine (LC) protects against multiorgan damage through its antioxidant properties and preservation of the mitochondria. Little information is available about the effects of LC on...
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Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy

Park Y, Ban TH, Kim HD, Ko EJ, Lee J, Kim SC, Park CW, Yang CW, Kim YS, Chung BH

Background/Aims: We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). Methods: This study enrolled 169 patients...
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Usefulness of BK virus-specific interferon-γ enzyme-linked immunospot assay for predicting the outcome of BK virus infection in kidney transplant recipients

Bae H, Na DH, Chang JY, Park KH, Min JW, Ko EJ, Lee H, Yang CW, Chung BH, Oh EJ

Background/Aims To investigate if BK virus (BKV)-specific T cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BK virus infection in kidney transplant recipients (KTRs). Methods We...
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Acute allograft dysfunction mimicking thrombotic microangiopathy in kidney transplant recipient with renal infarction: case report and review of literatures

Lee S, Ho LY, Chung BH, Park SC, Yang CW

Acute allograft dysfunction is rarely observed in kidney transplantation (KT). We report an unusual case of acute allograft dysfunction mimicking thrombotic microangiopa- thy (TMA) in recipient with renal infarction. A 65-year-old man...
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Differential impact of allograft rejection on kidney transplant patients with BK virus infection

Min JW, Park JB, Park JH, Park JW, Yang J, Ahn C, Yang CW, Chung BH

Background: BK virus-associated nephropathy (BKVAN) is a known risk factor for allograft dysfunction and graft failure in kidney transplant recipients. The mainstay of treatment for BKVAN is reduction of immunosuppression...
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Usefulness of pre- and post-transplant BK virus-specific ELISPOT assay for predicting the outcome of BK virus infection in kidney transplant recipients

Ko EJ, Bae H, Park KH, Yang CW, Chung BH, Oh EJ

Background: To investigate if BK virus (BKV)-specific T cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay at pre- and post-transplant can predict the outcome of BKV infection in kidney...
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The clinical utility of preformed C1q-binding donor-specific anti-HLA antibodies in kidney transplantation

Lee S, Yang CW, Chung BH

Background: The role of C1q-binding donor-specific antibody (DSA) in antibody-mediated rejection (AMR) is considered important. De novo C1q-binding DSA is well known as an associated factor for increased risk of...
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The clinical impact of preformed human leukocyte antigen-DQ donor-specific antibodies on graft outcomes in kidney transplantation

Lee S, Chung BH, Yang CW

Background: De-novo human leukocyte antigen (HLA)-DQ donor-specific antibody (DSA) is well known as a risk factor for graft dysfunction and graft loss in kidney transplantation (KT). Recently, the influence of...
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Changes of T lymphocyte subsets after kidney transplantation according to induction immunosuppressants

Kim HD, Bae H, Yang CW, Oh EJ, Chung BH

Background: The aim of this study is to investigate the change of T cell subsets during early post-transplant period according to the type of induction therapy (anti-thymocyte globulin [ATG] vs....
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Human leukocyte antigen-DR/DQ eplet mismatch analysis for primary alloimmune risk stratification of non-sensitized kidney transplant recipients

Lee H, Min JW, Kang H, Yang CW, Chung BH, Oh EJ

Background: Human leukocyte antigen (HLA) analysis has been suggested as a predictive tool for alloimmune risk stratification in kidney transplantation (KT). We investigated whether the whole or single molecule HLA...
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Combined impact of pre-sensitization and delayed graft function on the development of allograft rejection in deceased donor kidney transplantation: nationwide cohort study

Lee H, Park Y, Ban TH, Song SH, Song SH, Yang J, Ahn C, Yang CW, Chung BH

Background: Both pre-sensitization to human leukocyte antigen and delayed graft function (DGF) is well documented to be associated with poor allograft outcome. The aim of this study is to investigate...
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Impact of kidney and recipient weight incompatibility on the allograft outcomes in kidney transplant recipients with pre-transplant diabetes mellitus: a single center retrospective cohort study

Park Y, Lee H, Ko J, Yang CW, Chung BH

Background: The aim of this study was to analyze the impact on the adverse allograft outcome of transplanting relatively small kidneys in patients with pre-transplant diabetes mellitus (DM). Methods: From January...
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Clinical outcomes of infection-related hospitalization in incident peritoneal dialysis patients

Jeon Y, Kim HD, Hong YA, Kim HW, Yang CW, Chang YK, Kim YK

Background: Infection is the second leading cause of death in patients undergoing long-term dialysis. Peritoneal dialysis (PD) is associated with an increased risk of infection-related hospitalization (IRH) when compared with...
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