- Derivation of endothelial cells from porcine induced pluripotent stem cells by optimized single layer culture system
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Wei R, Lv J, Li X, Li Y, Xu Q, Jin J, Zhang Y, Liu Z
- KMID: 2469024
- J Vet Sci.
- 2020 Jan;21(1):e9.
- doi: 10.4142/jvs.2020.21.e9
Regenerative therapy holds great promise in the development of cures of some untreatable diseases such as cardiovascular diseases, and pluripotent stem cells (PSCs) including induced PSCs (iPSCs) are the most... -
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- Reprogramming of Cancer Cells into Induced Pluripotent Stem Cells Questioned
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Bang JS, Choi NY, Lee M, Ko K, Park YS, Ko K
- KMID: 2465883
- Int J Stem Cells.
- 2019 Nov;12(3):430-439.
- doi: 10.15283/ijsc19067
BACKGROUND AND OBJECTIVES: Several recent studies have claimed that cancer cells can be reprogrammed into induced pluripotent stem cells (iPSCs). However, in most cases, cancer cells seem to be resistant... -
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- Human Induced Pluripotent Stem Cells: Clinical Significance and Applications in Neurologic Diseases
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Chang EA, Jin SW, Nam MH, Kim SD
- KMID: 2457939
- J Korean Neurosurg Soc.
- 2019 Sep;62(5):493-501.
- doi: 10.3340/jkns.2018.0222
The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of... -
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- Comparative Evaluation of Hormones and Hormone-Like Molecule in Lineage Specification of Human Induced Pluripotent Stem Cells
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Choi SA, An JH, Lee SH, Lee GH, Yang HJ, Jeong PS, Cha JJ, Lee S, Park YH, Song BS, Sim BW, Kim YH, Kim JS, Jin YB, Huh JW, Lee SR, Lee JH, Kim SU
- KMID: 2465895
- Int J Stem Cells.
- 2019 Jul;12(2):240-250.
- doi: 10.15283/ijsc18137
BACKGROUND AND OBJECTIVES: Proficient differentiation of human pluripotent stem cells (hPSCs) into specific lineages is required for applications in regenerative medicine. A growing amount of evidences had implicated hormones and... -
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- Alteration of Genomic Imprinting Status of Human Parthenogenetic Induced Pluripotent Stem Cells during Neural Lineage Differentiation
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Lee HJ, Choi NY, Lee SW, Lee Y, Ko K, Kim GJ, Hwang HS, Ko K
- KMID: 2447222
- Int J Stem Cells.
- 2019 Mar;12(1):31-42.
- doi: 10.15283/ijsc18084
BACKGROUND AND OBJECTIVES: Genomic imprinting modulates growth and development in mammals and is associated with genetic disorders. Although uniparental embryonic stem cells have been used to study genomic imprinting, there... -
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- Determining Osteogenic Differentiation Efficacy of Pluripotent Stem Cells by Telomerase Activity
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Zhang S, Sun Y, Sui Y, Li Y, Luo Z, Xiao X, Zhou P, Wei S
- KMID: 2441266
- Tissue Eng Regen Med.
- 2018 Dec;15(6):751-760.
- doi: 10.1007/s13770-018-0138-6
BACKGROUND: Bone tissue engineering based on pluripotent stem cells (PSCs) is a new approach to deal with bone defects. Protocols have been developed to generate osteoblasts from PSCs. However, the... -
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- Applications of kidney organoids derived from human pluripotent stem cells
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Kim YK, Nam SA, Yang CW
- KMID: 2415990
- Korean J Intern Med.
- 2018 Jul;33(4):649-659.
- doi: 10.3904/kjim.2018.198
The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing... -
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- Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta
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Bamba Y, Nonaka M, Sasaki N, Shofuda T, Kanematsu , Suemizu H, Higuchi Y, Pooh RK, Kanemura Y, Okano H, Yamasaki M
- KMID: 2397624
- Asian Spine J.
- 2017 Dec;11(6):870-879.
- doi: 10.4184/asj.2017.11.6.870
STUDY DESIGN: We established induced pluripotent stem cells (iPSCs) and neural stem/progenitor cells (NSPCs) from three newborns with spina bifida aperta (SBa) using clinically practical methods. PURPOSE: We aimed to develop... -
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- Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation
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Wu CE, Yu CW, Chang KW, Chou WH, Lu CY, Ghelfi E, Wu FC, Jan PS, Huang MC, Allard P, Lin SP, Ho HN, Chen HF
- KMID: 2394307
- Exp Mol Med.
- 2017 Sep;49(9):e376.
- doi: 10.1038/emm.2017.134
Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), represent potentially unlimited cell sources for clinical applications. Previous studies have suggested that hPSCs may benefit... -
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- Rapid generation of OPC-like cells from human pluripotent stem cells for treating spinal cord injury
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Kim DS, Jung SJ, Lee JS, Lim BY, Kim HA, Yoo JE, Kim DW, Leem JW
- KMID: 2388359
- Exp Mol Med.
- 2017 Jul;49(7):e361.
- doi: 10.1038/emm.2017.106
Remyelination via the transplantation of oligodendrocyte precursor cells (OPCs) has been considered as a strategy to improve the locomotor deficits caused by traumatic spinal cord injury (SCI). To date, enormous... -
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- From Bench to Market: Preparing Human Pluripotent Stem Cells Derived Cardiomyocytes for Various Applications
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Moon SH, Bae D, Jung TH, Chung EB, Jeong YH, Park SJ, Chung HM
- KMID: 2384596
- Int J Stem Cells.
- 2017 May;10(1):1-11.
- doi: 10.15283/ijsc17024
Human cardiomyocytes (CMs) cease to proliferate and remain terminally differentiated thereafter, when humans reach the mid-20s. Thus, any damages sustained by myocardium tissue are irreversible, and they require medical interventions... -
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- CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells
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Kim EJ, Kang KH, Ju JH
- KMID: 2365977
- Korean J Intern Med.
- 2017 Jan;32(1):42-61.
- doi: 10.3904/kjim.2016.198
Recent advances in genome editing with programmable nucleases have opened up new avenues for multiple applications, from basic research to clinical therapy. The ease of use of the technology—and particularly... -
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- Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS
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Park JH, Park HS, Hong S, Kang S
- KMID: 2367552
- Exp Mol Med.
- 2016 Dec;48(12):e276.
- doi: 10.1038/emm.2016.113
Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disease characterized by the loss of motor neurons in the spinal cord and brain. Mutations in Cu/Zn superoxide dismutase 1 (SOD1)... -
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- Functional Comparison of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells as Sources of Hepatocyte-Like Cells
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Jeong J, Kim KN, Chung MS, Kim HJ
- KMID: 2360886
- Tissue Eng Regen Med.
- 2016 Dec;13(6):740-749.
- doi: 10.1007/s13770-016-0094-y
Pluripotent stem cells can differentiate into many cell types including mature hepatocytes, and can be used in the development of new drugs, treatment of diseases, and in basic research. In... -
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- Highly Efficient Reprogramming and Characterization of Induced Pluripotent Stem Cells by Using a Microwell Array
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Lee H, Kim GM, Choi JH, Park MH, Bae JS, Jin HK
- KMID: 2360881
- Tissue Eng Regen Med.
- 2016 Dec;13(6):691-700.
- doi: 10.1007/10.1007/s13770-016-0015-0
Reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) enables the possibility of generating patient-specific cells. However, the low efficiency issue associated with iPSCs generation has limited iPSCs... -
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- Hypoxia Enhances Osteogenic Differentiation in Retinoic Acid-Treated Murine-Induced Pluripotent Stem Cells
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Manokawinchoke J, Osathanon , Egusa H, Pavasant P
- KMID: 2360803
- Tissue Eng Regen Med.
- 2016 Oct;13(5):547-553.
- doi: 10.1007/s13770-016-9127-9
Hypoxic condition influences biological responses in various cell types. However, a hypoxic regulating osteogenic differentiation remains controversy. Here, an influence of short-term culture in hypoxic condition on osteogenic marker gene... -
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- Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease
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Son MY, Lee MO, Jeon H, Seol B, Kim JH, Chang JS, Cho YS
- KMID: 2361519
- Exp Mol Med.
- 2016 May;48(5):e232.
- doi: 10.1038/emm.2016.27
Autoimmune diseases (AIDs), a heterogeneous group of immune-mediated disorders, are a major and growing health problem. Although AIDs are currently treated primarily with anti-inflammatory and immunosuppressive drugs, the use of... -
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- Recent Stem Cell Advances: Cord Blood and Induced Pluripotent Stem Cell for Cardiac Regeneration- a Review
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Medhekar S, Shende VS, Chincholkar AB
- KMID: 2164157
- Int J Stem Cells.
- 2016 May;9(1):21-30.
- doi: 10.15283/ijsc.2016.9.1.21
Stem cells are primitive self renewing undifferentiated cell that can be differentiated into various types of specialized cells like nerve cell, skin cells, muscle cells, intestinal tissue, and blood cells.... -
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- Questions Surrounding iPS Cells in Japan
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Yui Y
- KMID: 2164154
- Int J Stem Cells.
- 2016 May;9(1):1-2.
- doi: 10.15283/ijsc.2016.9.1.1
No abstract available. -
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- Induced Pluripotent Stem Cells as a Novel Tool in Psychiatric Research
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Kim S, Kim MK, Oh D, Lee SH, Kim B
- KMID: 2316592
- Psychiatry Investig.
- 2016 Jan;13(1):8-17.
- doi: 10.4306/pi.2016.13.1.8
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a valuable opportunity to study neurodevelopmental and neurodegenerative psychiatric diseases by offering an unlimited source for patient-specific neuronal and... -
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