J Neurogastroenterol Motil.  2011 Jul;17(3):287-293.

Effects of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors on the Rate of Gastric Emptying: A Crossover Study Using a Continuous Real-Time 13C Breath Test (BreathID System)

• Nonaka T
• Kessoku T
• Ogawa Y
• Imajyo K
• Yanagisawa S
• Shiba T
• Sakaguchi
• Atsukawa K
• Takahashi
• Sekino Y
• Sakai E
• Uchiyama T
• Iida H
• Hosono K
• Endo H
• Sakamoto Y
• Fujita K
• Yoneda M
• Koide T
• Takahashi
• Tokoro C
• Abe Y
• Gotoh E
• Maeda S
• Nakajima A
• Inamori M

Abstract

BACKGROUND/AIMS
The effects of Histamine-2 receptor antagonists and proton pump inhibitors on the gastrointestinal motility have not yet been sufficiently investigated. The aim of this study was to determine the effects of intravenous bolus administration of famotidine and omeprazole on the rate of gastric emptying using the continuous 13C breath test (BreathID system, Exalenz Bioscience Ltd, Israel).
METHODS
Twelve healthy male volunteers participated in this randomized, 3-way crossover study. After fasting overnight, the subjects were randomly assigned to receive 20 mg of famotidine, 20 mg of omeprazole or 20 mL of saline alone by intravenous bolus injection before a test meal (200 kcal per 200 mL, containing 100 mg of 13C-acetate). Gastric emptying was monitored for 4 hours after the ingestion of test meal by the 13C-acetic acid breath test performed using the BreathID system.
RESULTS
No significant differences in the calculated parameters, namely, the T1/2, Tlag, GEC, beta and kappa, were observed among the 3 test conditions.
CONCLUSIONS
The study revealed that intravenous administration of gastric acid suppressant drugs had no significant influence on the rate of gastric emptying in comparison with that of saline alone as a placebo. Our results indicating the absence of any effect of either famotidine or omeprazole on accelerating the rate of gastric emptying suggest that both medications can be administered safely to patients suffering from hemorrhagic peptic ulcers who need to be kept nil by mouth from the viewpoint of possible acceleration of gastrointestinal motility in the clinical setting.

Keyword

Breath tests; Gastric emptying; Histamine-2 antagonists; Proton pump inhibitors

MeSH Terms

Acceleration
Administration, Intravenous
Breath Tests
Cross-Over Studies
Eating
Famotidine
Fasting
Gastric Acid
Gastric Emptying
Gastrointestinal Motility
Humans
Male
Meals
Mouth
Omeprazole
Peptic Ulcer
Proton Pump Inhibitors
Proton Pumps
Protons
Stress, Psychological
Famotidine
Omeprazole
Proton Pump Inhibitors
Proton Pumps
Protons