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Association between interstitial cells of Cajal and anti-vinculin antibody in human stomach

Kim JH, Nam SJ, Park SC, Lee SH, Kim TS, Lee M, Park JM, Choi DH, Kang CD, Lee SJ, Ryu YJ, Lee K, Park SY

Interstitial cells of Cajal (ICC) are known as the pacemaker cells of gastrointestinal tract, and it has been reported that acute gastroenteritis induces intestinal dysmotility through antibody to vinculin, a...
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Changes in Gastrointestinal Physiology in Obese Patients

Yun SH, Park JK, Shin JE, Diet, Obesity, and Metabolism Research Group of Korean Society of Neurogastroenterology and Motility

Obesity is a prevalent disease with significant morbidity and mortality. It is a state of chronic low-grade inflammation due to excess body fat. Weight homeostasis is maintained through changes in...
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Intranasal Administration of Oxytocin Attenuates Stress Responses Following Chronic Complicated Stress in Rats

Yang Y, Yu H, Babygirija R, Shi B, Sun W, Zheng X, Zheng J

  • KMID: 2460490
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):611-622.
  • doi: 10.5056/jnm19065
BACKGROUND/AIMS: Gastrointestinal (GI) symptoms may develop when we fail to adapt to various stressors of our daily life. Central oxytocin (OXT) can counteract the biological actions of corticotropin-releasing factor (CRF),...
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Pyridostigmine in Pediatric Intestinal Pseudo-obstruction: Case Report of a 2-year Old Girl and Literature Review

Di Nardo G, Viscogliosi F, Esposito F, Stanghellini V, Villa MP, Parisi P, Morlando A, Calò G, De Giorgio R

  • KMID: 2460479
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):508-514.
  • doi: 10.5056/jnm19078
Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes. The diagnosis is...
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Effect of Delayed Elevation of Thyrotropin on Feeding Intolerance in Very Low Birth Weight Infants

Hyun JK, Choi SY, Jung YJ, Lee JH

PURPOSE: We investigated the effect of delayed elevation of thyrotropin (TSH) (deTSH) on gastrointestinal motility in very low birth weight infants (VLBWI). METHODS: This study retrospectively investigated 228 premature VLBWI aged...
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Fluoroscopic Characterization of Colonic Dysmotility Associated to Opioid and Cannabinoid Agonists in Conscious Rats

Díaz-Ruano S, López-Pérez AE, Girón R, Pérez-García I, Martín-Fontelles MI, Abalo R

  • KMID: 2449102
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):300-315.
  • doi: 10.5056/jnm18202
BACKGROUND/AIMS: Gastrointestinal adverse effects have a major impact on health and quality of life in analgesics users. Non-invasive methods to study gastrointestinal motility are of high interest. Fluoroscopy has been...
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Ameliorating Effects of Electroacupuncture on Dysmotility, Inflammation, and Pain Mediated via the Autonomic Mechanism in a Rat Model of Postoperative Ileus

Murakami H, Li S, Foreman R, Yin J, Hirai T, Chen JD

  • KMID: 2449101
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):286-299.
  • doi: 10.5056/jnm18094
BACKGROUND/AIMS: Postoperative ileus increases healthcare costs and reduces the postoperative quality of life (QOL). The aim of this study is to investigate effects and mechanisms of electroacupuncture (EA) at ST36...
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Control of Motility in the Internal Anal Sphincter

Keef KD, Cobine CA

  • KMID: 2449091
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):189-204.
  • doi: 10.5056/jnm18172
The internal anal sphincter (IAS) plays an important role in the maintenance of fecal continence since it generates tone and is responsible for > 70% of resting anal pressure. During...
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Colonic Electromechanical Abnormalities Underlying Post-operative Ileus: A Systematic and Critical Review

Wells CI, O'Grady G, Bissett IP

  • KMID: 2433496
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):36-47.
  • doi: 10.5056/jnm18030
Post-operative ileus (POI) is an inevitable consequence of major abdominal surgery, and may be prolonged in up to 30% of patients. Ileus is commonly presumed to result from paralysis of...
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Ophthalmoplegia in Mitochondrial Disease

Lee SJ, Na JH, Han J, Lee YM

PURPOSE: To evaluate the classification, diagnosis, and natural course of ophthalmoplegia associated with mitochondrial disease. MATERIALS AND METHODS: Among 372 patients with mitochondrial disease who visited our hospital between January 2006...
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Role of High-affinity Choline Transporter 1 in Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome

Lin MJ, Yu BP

  • KMID: 2422854
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):643-655.
  • doi: 10.5056/jnm18040
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a common disease characterized by intestinal dysmotility, the mechanism of which remains elusive. We aim to determine whether the high-affinity choline transporter 1 (CHT1),...
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Effects of Fengliao-Changweikang in Diarrhea-predominant Irritable Bowel Syndrome Rats and Its Mechanism Involving Colonic Motility

Jia M, Lu X, Wang Z, Zhao L, Zhang S

  • KMID: 2417393
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):479-489.
  • doi: 10.5056/jnm17093
BACKGROUND/AIMS: This study was designed to investigate the effect of Fengliao-Changweikang (FLCWK) in diarrhea-predominant irritable bowel syndrome (IBS-D) rats and explore its underlying mechanisms. METHODS: IBS-D model rats were induced by...
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Anorectal Manometry in Defecatory Disorders: A Comparative Analysis of High-resolution Pressure Topography and Waveform Manometry

Lee YY, Erdogan A, Yu S, Dewitt A, Rao SS

  • KMID: 2417391
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):460-468.
  • doi: 10.5056/jnm17081
BACKGROUND/AIMS: Whether high-resolution anorectal pressure topography (HRPT), having better fidelity and spatio-temporal resolution is comparable to waveform manometry (WM) in the diagnosis and characterization of defecatory disorders (DD) is not...
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Effect of antispasmodic agents for the treatment of irritable bowel syndrome

Lee SH, Jee SR

Antispasmodics are effective in reducing abdominal pain and controlling spasm. Irritable bowel syndrome (IBS) patients have characteristic key factors such as intestinal motility disorder and visceral hypersensitivity. So antispasmodics have...
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Regulation of Intracellular Calcium by Endoplasmic Reticulum Proteins in Small Intestinal Interstitial Cells of Cajal

Park CG, Wu MJ, Hong C, Jo JY, Jiao HY, Park H, Jun JY, Choi S

  • KMID: 2417280
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):128-137.
  • doi: 10.5056/jnm16212
BACKGROUND/AIMS: We investigated the role of representative endoplasmic reticulum proteins, stromal interaction molecule 1 (STIM1), and store-operated calcium entry-associated regulatory factor (SARAF) in pacemaker activity in cultured interstitial cells of...
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Increased Postprandial Colonic Motility and Autonomic Nervous System Activity in Patients With Irritable Bowel Syndrome: A Prospective Study

Tanaka Y, Kanazawa M, Palsson OS, Van Tilburg MA, Gangarosa , Fukudo S, Drossman D, Whitehead

  • KMID: 2417276
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):87-95.
  • doi: 10.5056/jnm16216
BACKGROUND/AIMS: The prevalence and severity of irritable bowel syndrome (IBS) declines with age, but the cause of this is unknown. This study tested 2 hypotheses: (1) autonomic nervous system responses...
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Neuromodulation via Interferential Electrical Stimulation as a Novel Therapy in Gastrointestinal Motility Disorders

Moore JS, Gibson PR, Burgell RE

  • KMID: 2417269
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):19-29.
  • doi: 10.5056/jnm17071
The concept of therapeutic percutaneous neuromodulation has, until recently, been limited by the ability to penetrate deeply enough to stimulate internal organs. By utilizing 2 medium frequency, slightly out of...
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Vomiting

Kim GH, Jung KW

Many disorders can cause either acute or chronic vomiting. However, in most cases, vomiting is self-limited. A correct diagnosis is possible by conducting careful histories and physical examinations. In cases...
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Ardipusilloside-I stimulates gastrointestinal motility and phosphorylation of smooth muscle myosin by myosin light chain kinase

Xu Z, Liang H, Zhang M, Tao X, Dou D, Hu L, Kang T

Ardipusilloside-I is a natural triterpenoid saponin, which was isolated from Ardisia pusilla A. DC. The aim of the study was to evaluate the stimulation of ardipusilloside-I on gastrointestinal motility in...
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The Effect of Deoxycholic Acid on Secretion and Motility in the Rat and Guinea Pig Large Intestine

Kim NH, Park JH, Park JS, Joung YH

  • KMID: 2395430
  • J Neurogastroenterol Motil.
  • 2017 Oct;23(4):606-615.
  • doi: 10.5056/jnm16201
BACKGROUND/AIMS: Bile acid is an important luminal factor that affects gastrointestinal motility and secretion. We investigated the effect of bile acid on secretion in the proximal and distal rat colon...
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