J Korean Med Assoc.  2009 Sep;52(9):920-927. 10.5124/jkma.2009.52.9.920.

Gastrointestinal Motility Modulating Drugs

• Lee OY

• KMID: 1936496
• DOI: http://doi.org/10.5124/jkma.2009.52.9.920

Abstract

Gastrointestinal motility modulating drugs include all compounds which have pharmacological activity of modulating (stimulating or inhibiting) gastrointestinal motility. They are mainly used for the treatment of functional gastrointestinal diseases. Gastrointestinal motility modulating drugs include 5HT receptor agonists, antagonists, and antidopaminergic agents. Many new gastrointestinal motility modulating drugs are currently under investigation. The aims of this article are to review the mechanism of action, efficacy and side effects of the gastrointestinal motility modulating drugs.

Keyword

Motility modulating drugs; Pharmacotherapy; Prokinetics; Functional gastrointestinal diseases

MeSH Terms

Gastrointestinal Diseases
Gastrointestinal Motility

Reference

1. Karamanolis G, Tack J. Promotility medication-now and in the future. Dig Dis. 2006. 24:297–307.

2. Tonini M, Cipollina L, Poluzzi E, Crema F, Corazza GR, De Ponti F. Clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther. 2004. 19:379–390.

3. Tack J. Prokinetics and fundic relaxants in upper functional GI disorders. Curr Opin Pharmacol. 2008. 8:690–696.

4. Kindt S, Tack J. Mechanisms of serotonergic agents for treatment of gastrointestinal motility and functional bowel disorders. Neuogastroenterol Motility. 2007. 19:32–39.

5. Costedio MM, Hyman N, Mawe GM. Serotonin and its role in colonic function and in gastrointestinal disorders. Dis Colon Rectum. 2007. 50:376–388.